WNT Signaling in Lung Disease: A Failure or a Regeneration Signal?
The WNT family of signaling proteins is essential to organ development in general and lung morphogenesis in particular. Originally identified as a developmentally active signaling pathway, the WNT pathway has recently been linked to the pathogenesis of important lung diseases, in particular lung can...
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| Veröffentlicht in: | American journal of respiratory cell and molecular biology 2010-01, Vol.42 (1), p.21-31 |
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| container_title | American journal of respiratory cell and molecular biology |
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| creator | Konigshoff, Melanie Eickelberg, Oliver |
| description | The WNT family of signaling proteins is essential to organ development in general and lung morphogenesis in particular. Originally identified as a developmentally active signaling pathway, the WNT pathway has recently been linked to the pathogenesis of important lung diseases, in particular lung cancer and pulmonary fibrosis. This review summarizes our current understanding about WNT signaling in lung development and disease, and is structured into three chapters. The first chapter presents an introduction to WNT signaling, outlining WNT proteins, their receptors and signaling intermediates, as well as the regulation of this complex pathway. The second chapter focuses on the role of WNT signaling in the normal embryonic and adult lung, and highlights recent findings of altered WNT signaling in lung diseases, such as lung cancer, pulmonary fibrosis, or pulmonary arterial hypertension. In the last chapter, we will discuss novel data and ideas about the biological effects of WNT signaling on the cellular level, highlighting pleiotropic effects induced by WNT ligands on distinct cell types, and how these cellular effects may be relevant to the pathogenesis of the aforementioned diseases. |
| doi_str_mv | 10.1165/rcmb.2008-0485TR |
| format | Article |
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| source | MEDLINE; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals beta Catenin - metabolism Epithelial Cells - metabolism Epithelium - pathology Fibrosis - pathology Humans Lung - pathology Lung Diseases - metabolism Lung Diseases - pathology Lung Neoplasms - metabolism Mesoderm - pathology Models, Biological Pulmonary Fibrosis - pathology Regeneration Signal Transduction Wnt Proteins - metabolism |
| title | WNT Signaling in Lung Disease: A Failure or a Regeneration Signal? |
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