Sequential analysis of fMRI images: A new approach to study human epileptic networks
Summary Purpose: The aim of this study was to introduce a new approach for analysis of functional magnetic resonance imaging (fMRI) data in order to illustrate the temporal development of the blood oxygenation level–dependent (BOLD) signal changes induced by epileptic seizures. Method: In order to...
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| Veröffentlicht in: | Epilepsia (Copenhagen) 2009-12, Vol.50 (12), p.2526-2537 |
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| creator | Donaire, Antonio Falcón, Carlos Carreno, Mar Bargallo, Nuria Rumià, Jordi Setoain, Javier Maestro, Iratxe Boget, Teresa Pintor, Luis Agudo, Rolando Falip, Merce Fernández, Santiago |
| description | Summary
Purpose: The aim of this study was to introduce a new approach for analysis of functional magnetic resonance imaging (fMRI) data in order to illustrate the temporal development of the blood oxygenation level–dependent (BOLD) signal changes induced by epileptic seizures.
Method: In order to sequentially analyze the fMRI images acquired during epileptic seizures, a continuous series of echo planar imaging (EPI) scans covering the complete period of a seizure was acquired. Data were segmented into 10‐s blocks. Each block, representing a unique experimental condition, was contrasted with a neutral (no seizure) baseline condition. Visual comparison of the activations from one block to the next highlighted the course of activations and deactivations during the seizure event. This analysis was applied to three independent seizures of one patient with peri‐rolandic epilepsy secondary to chronic encephalitis: one seizure before epilepsy surgery and two after unsuccessful tailored resection. Observations were compared to results from invasive subdural electroencephalography (EEG) monitoring, single‐photon emission computed tomography (SPECT) coregistered to MRI (SISCOM), and independent component analysis (ICA), a model‐free method of BOLD‐signal analysis.
Results: The initial increase in BOLD signal occurred 10–40 s before clinical onset in the same location compared to the seizure‐onset zone determined by invasive subdural evaluation and SISCOM. Sequential involvement of cortical and subcortical structures was in agreement with SISCOM, intracranial EEG recordings, and ICA results.
Discussion: In selected patients, sequential analysis of changes in BOLD signal induced by epileptic seizures might represent a useful approach for investigating the temporal development of brain activity during epileptic seizures, thereby allowing imaging of those cerebral structures involved in seizure generation and propagation. |
| doi_str_mv | 10.1111/j.1528-1167.2009.02152.x |
| format | Article |
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Purpose: The aim of this study was to introduce a new approach for analysis of functional magnetic resonance imaging (fMRI) data in order to illustrate the temporal development of the blood oxygenation level–dependent (BOLD) signal changes induced by epileptic seizures.
Method: In order to sequentially analyze the fMRI images acquired during epileptic seizures, a continuous series of echo planar imaging (EPI) scans covering the complete period of a seizure was acquired. Data were segmented into 10‐s blocks. Each block, representing a unique experimental condition, was contrasted with a neutral (no seizure) baseline condition. Visual comparison of the activations from one block to the next highlighted the course of activations and deactivations during the seizure event. This analysis was applied to three independent seizures of one patient with peri‐rolandic epilepsy secondary to chronic encephalitis: one seizure before epilepsy surgery and two after unsuccessful tailored resection. Observations were compared to results from invasive subdural electroencephalography (EEG) monitoring, single‐photon emission computed tomography (SPECT) coregistered to MRI (SISCOM), and independent component analysis (ICA), a model‐free method of BOLD‐signal analysis.
Results: The initial increase in BOLD signal occurred 10–40 s before clinical onset in the same location compared to the seizure‐onset zone determined by invasive subdural evaluation and SISCOM. Sequential involvement of cortical and subcortical structures was in agreement with SISCOM, intracranial EEG recordings, and ICA results.
Discussion: In selected patients, sequential analysis of changes in BOLD signal induced by epileptic seizures might represent a useful approach for investigating the temporal development of brain activity during epileptic seizures, thereby allowing imaging of those cerebral structures involved in seizure generation and propagation.</description><identifier>ISSN: 0013-9580</identifier><identifier>EISSN: 1528-1167</identifier><identifier>DOI: 10.1111/j.1528-1167.2009.02152.x</identifier><identifier>PMID: 19490031</identifier><identifier>CODEN: EPILAK</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Brain Mapping - methods ; Cerebral Cortex - physiopathology ; Echo-Planar Imaging - statistics & numerical data ; Electrodes, Implanted ; Electroencephalography - statistics & numerical data ; Epilepsy - diagnosis ; Epilepsy - physiopathology ; Epilepsy - surgery ; Epilepsy, Rolandic - diagnosis ; Epilepsy, Rolandic - physiopathology ; Epilepsy, Rolandic - surgery ; Female ; Follow-Up Studies ; Functional neuroimaging ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Ictal‐fMRI ; Image Enhancement ; Image Interpretation, Computer-Assisted ; Magnetic Resonance Imaging - methods ; Magnetic Resonance Imaging - statistics & numerical data ; Male ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Neuropharmacology ; Oxygen - blood ; Partial seizures ; Pharmacology. Drug treatments ; Subdural Space ; Tomography, Emission-Computed, Single-Photon ; Treatment Outcome</subject><ispartof>Epilepsia (Copenhagen), 2009-12, Vol.50 (12), p.2526-2537</ispartof><rights>Wiley Periodicals, Inc. © 2009 International League Against Epilepsy</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4482-1c0e452a87c8be8bf22158700d035a4d37ea24d5ea511262c41bc3253c0585613</citedby><cites>FETCH-LOGICAL-c4482-1c0e452a87c8be8bf22158700d035a4d37ea24d5ea511262c41bc3253c0585613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1528-1167.2009.02152.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1528-1167.2009.02152.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,1435,27931,27932,45581,45582,46416,46840</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22228770$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19490031$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Donaire, Antonio</creatorcontrib><creatorcontrib>Falcón, Carlos</creatorcontrib><creatorcontrib>Carreno, Mar</creatorcontrib><creatorcontrib>Bargallo, Nuria</creatorcontrib><creatorcontrib>Rumià, Jordi</creatorcontrib><creatorcontrib>Setoain, Javier</creatorcontrib><creatorcontrib>Maestro, Iratxe</creatorcontrib><creatorcontrib>Boget, Teresa</creatorcontrib><creatorcontrib>Pintor, Luis</creatorcontrib><creatorcontrib>Agudo, Rolando</creatorcontrib><creatorcontrib>Falip, Merce</creatorcontrib><creatorcontrib>Fernández, Santiago</creatorcontrib><title>Sequential analysis of fMRI images: A new approach to study human epileptic networks</title><title>Epilepsia (Copenhagen)</title><addtitle>Epilepsia</addtitle><description>Summary
Purpose: The aim of this study was to introduce a new approach for analysis of functional magnetic resonance imaging (fMRI) data in order to illustrate the temporal development of the blood oxygenation level–dependent (BOLD) signal changes induced by epileptic seizures.
Method: In order to sequentially analyze the fMRI images acquired during epileptic seizures, a continuous series of echo planar imaging (EPI) scans covering the complete period of a seizure was acquired. Data were segmented into 10‐s blocks. Each block, representing a unique experimental condition, was contrasted with a neutral (no seizure) baseline condition. Visual comparison of the activations from one block to the next highlighted the course of activations and deactivations during the seizure event. This analysis was applied to three independent seizures of one patient with peri‐rolandic epilepsy secondary to chronic encephalitis: one seizure before epilepsy surgery and two after unsuccessful tailored resection. Observations were compared to results from invasive subdural electroencephalography (EEG) monitoring, single‐photon emission computed tomography (SPECT) coregistered to MRI (SISCOM), and independent component analysis (ICA), a model‐free method of BOLD‐signal analysis.
Results: The initial increase in BOLD signal occurred 10–40 s before clinical onset in the same location compared to the seizure‐onset zone determined by invasive subdural evaluation and SISCOM. Sequential involvement of cortical and subcortical structures was in agreement with SISCOM, intracranial EEG recordings, and ICA results.
Discussion: In selected patients, sequential analysis of changes in BOLD signal induced by epileptic seizures might represent a useful approach for investigating the temporal development of brain activity during epileptic seizures, thereby allowing imaging of those cerebral structures involved in seizure generation and propagation.</description><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping - methods</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Echo-Planar Imaging - statistics & numerical data</subject><subject>Electrodes, Implanted</subject><subject>Electroencephalography - statistics & numerical data</subject><subject>Epilepsy - diagnosis</subject><subject>Epilepsy - physiopathology</subject><subject>Epilepsy - surgery</subject><subject>Epilepsy, Rolandic - diagnosis</subject><subject>Epilepsy, Rolandic - physiopathology</subject><subject>Epilepsy, Rolandic - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Functional neuroimaging</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Ictal‐fMRI</subject><subject>Image Enhancement</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetic Resonance Imaging - statistics & numerical data</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Oxygen - blood</subject><subject>Partial seizures</subject><subject>Pharmacology. Drug treatments</subject><subject>Subdural Space</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><subject>Treatment Outcome</subject><issn>0013-9580</issn><issn>1528-1167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1PwyAUhonR6Jz-BcON8ar1AKVQEy-WxY8lMxqd14RRqp1dW0ub2X8vdYveem4g8Bw474MQJhASX5erkHAqA0JiEVKAJATqD8KvPTT6vdhHIwDCgoRLOELHzq0AQMSCHaIjkkQJACMjtHixn50t21wXWJe66F3ucJXh7OF5hvO1frPuCk9waTdY13VTafOO2wq7tkt7_N6tdYltnRe2bnPjqXZTNR_uBB1kunD2dLeO0evtzWJ6H8wf72bTyTwwUSRpQAzYiFMthZFLK5cZ9SmkAEiBcR2lTFhNo5RbzQmhMTURWRpGOTPAJY8JG6OL7bt-MJ_CtWqdO2OLQpe26pwSLKLAIE48KbekaSrnGpupuvHpml4RUINStVKDOTWYU4NS9aNUffnWs90n3XJt07_GnUMPnO8A7YwuskaXJne_HPUlhQDPXW-5jffV_3sAdfM0G3bsG955kDk</recordid><startdate>200912</startdate><enddate>200912</enddate><creator>Donaire, Antonio</creator><creator>Falcón, Carlos</creator><creator>Carreno, Mar</creator><creator>Bargallo, Nuria</creator><creator>Rumià, Jordi</creator><creator>Setoain, Javier</creator><creator>Maestro, Iratxe</creator><creator>Boget, Teresa</creator><creator>Pintor, Luis</creator><creator>Agudo, Rolando</creator><creator>Falip, Merce</creator><creator>Fernández, Santiago</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200912</creationdate><title>Sequential analysis of fMRI images: A new approach to study human epileptic networks</title><author>Donaire, Antonio ; Falcón, Carlos ; Carreno, Mar ; Bargallo, Nuria ; Rumià, Jordi ; Setoain, Javier ; Maestro, Iratxe ; Boget, Teresa ; Pintor, Luis ; Agudo, Rolando ; Falip, Merce ; Fernández, Santiago</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4482-1c0e452a87c8be8bf22158700d035a4d37ea24d5ea511262c41bc3253c0585613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping - methods</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Echo-Planar Imaging - statistics & numerical data</topic><topic>Electrodes, Implanted</topic><topic>Electroencephalography - statistics & numerical data</topic><topic>Epilepsy - diagnosis</topic><topic>Epilepsy - physiopathology</topic><topic>Epilepsy - surgery</topic><topic>Epilepsy, Rolandic - diagnosis</topic><topic>Epilepsy, Rolandic - physiopathology</topic><topic>Epilepsy, Rolandic - surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Functional neuroimaging</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Ictal‐fMRI</topic><topic>Image Enhancement</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetic Resonance Imaging - statistics & numerical data</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Oxygen - blood</topic><topic>Partial seizures</topic><topic>Pharmacology. Drug treatments</topic><topic>Subdural Space</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Donaire, Antonio</creatorcontrib><creatorcontrib>Falcón, Carlos</creatorcontrib><creatorcontrib>Carreno, Mar</creatorcontrib><creatorcontrib>Bargallo, Nuria</creatorcontrib><creatorcontrib>Rumià, Jordi</creatorcontrib><creatorcontrib>Setoain, Javier</creatorcontrib><creatorcontrib>Maestro, Iratxe</creatorcontrib><creatorcontrib>Boget, Teresa</creatorcontrib><creatorcontrib>Pintor, Luis</creatorcontrib><creatorcontrib>Agudo, Rolando</creatorcontrib><creatorcontrib>Falip, Merce</creatorcontrib><creatorcontrib>Fernández, Santiago</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsia (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Donaire, Antonio</au><au>Falcón, Carlos</au><au>Carreno, Mar</au><au>Bargallo, Nuria</au><au>Rumià, Jordi</au><au>Setoain, Javier</au><au>Maestro, Iratxe</au><au>Boget, Teresa</au><au>Pintor, Luis</au><au>Agudo, Rolando</au><au>Falip, Merce</au><au>Fernández, Santiago</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sequential analysis of fMRI images: A new approach to study human epileptic networks</atitle><jtitle>Epilepsia (Copenhagen)</jtitle><addtitle>Epilepsia</addtitle><date>2009-12</date><risdate>2009</risdate><volume>50</volume><issue>12</issue><spage>2526</spage><epage>2537</epage><pages>2526-2537</pages><issn>0013-9580</issn><eissn>1528-1167</eissn><coden>EPILAK</coden><abstract>Summary
Purpose: The aim of this study was to introduce a new approach for analysis of functional magnetic resonance imaging (fMRI) data in order to illustrate the temporal development of the blood oxygenation level–dependent (BOLD) signal changes induced by epileptic seizures.
Method: In order to sequentially analyze the fMRI images acquired during epileptic seizures, a continuous series of echo planar imaging (EPI) scans covering the complete period of a seizure was acquired. Data were segmented into 10‐s blocks. Each block, representing a unique experimental condition, was contrasted with a neutral (no seizure) baseline condition. Visual comparison of the activations from one block to the next highlighted the course of activations and deactivations during the seizure event. This analysis was applied to three independent seizures of one patient with peri‐rolandic epilepsy secondary to chronic encephalitis: one seizure before epilepsy surgery and two after unsuccessful tailored resection. Observations were compared to results from invasive subdural electroencephalography (EEG) monitoring, single‐photon emission computed tomography (SPECT) coregistered to MRI (SISCOM), and independent component analysis (ICA), a model‐free method of BOLD‐signal analysis.
Results: The initial increase in BOLD signal occurred 10–40 s before clinical onset in the same location compared to the seizure‐onset zone determined by invasive subdural evaluation and SISCOM. Sequential involvement of cortical and subcortical structures was in agreement with SISCOM, intracranial EEG recordings, and ICA results.
Discussion: In selected patients, sequential analysis of changes in BOLD signal induced by epileptic seizures might represent a useful approach for investigating the temporal development of brain activity during epileptic seizures, thereby allowing imaging of those cerebral structures involved in seizure generation and propagation.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19490031</pmid><doi>10.1111/j.1528-1167.2009.02152.x</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Brain Mapping - methods Cerebral Cortex - physiopathology Echo-Planar Imaging - statistics & numerical data Electrodes, Implanted Electroencephalography - statistics & numerical data Epilepsy - diagnosis Epilepsy - physiopathology Epilepsy - surgery Epilepsy, Rolandic - diagnosis Epilepsy, Rolandic - physiopathology Epilepsy, Rolandic - surgery Female Follow-Up Studies Functional neuroimaging Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Ictal‐fMRI Image Enhancement Image Interpretation, Computer-Assisted Magnetic Resonance Imaging - methods Magnetic Resonance Imaging - statistics & numerical data Male Medical sciences Nervous system (semeiology, syndromes) Neurology Neuropharmacology Oxygen - blood Partial seizures Pharmacology. Drug treatments Subdural Space Tomography, Emission-Computed, Single-Photon Treatment Outcome |
| title | Sequential analysis of fMRI images: A new approach to study human epileptic networks |
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