Selection and bias-Two hostile brothers

We consider the situation where in a first stage of a clinical trial several treatments are compared with a single control and the ‘best’ treatment(s) are selected in an interim analysis to be carried on to the second stage. We quantify the mean bias and mean square error of the conventional estimat...

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Veröffentlicht in:	Statistics in medicine 2010-01, Vol.29 (1), p.1-13
Hauptverfasser:	Bauer, Peter, Koenig, Franz, Brannath, Werner, Posch, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	admission bias Area Under Curve Bias Clinical trials Comparative analysis Data Interpretation, Statistical Estimation bias Guanidines - administration & dosage Guanidines - therapeutic use Humans many one comparison mean bias mean square error Medical statistics Medical treatment Myocardial Infarction - therapy Randomized Controlled Trials as Topic - methods Research Design Sample Size sample size reassessment Sodium-Hydrogen Exchangers - antagonists & inhibitors Sulfones - administration & dosage Sulfones - therapeutic use treatment selection
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