Synthesis of a fluorescent chemosensor suitable for the imaging of zinc(II) in live cells

The synthesis of a coumarin-cyclen conjugate-based zinc-specific chemosensor and its ability to sense Zn 2+ in vitro is described. Using fluorescence microscopy, the chemosensor was shown to be capable of imaging Zn 2+ in live rat pituitary tumour cells. Graphic

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2003-07, Vol.13 (14), p.2251-2254
Hauptverfasser:	Lim, Nathaniel C., Yao, Lili, Freake, Hedley C., Brückner, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Animals Biological and medical sciences Cell Line, Tumor Chelating Agents - chemical synthesis Chemistry Coumarins - chemical synthesis Exact sciences and technology Fluorescent Dyes - chemical synthesis General, instrumentation Indicators and Reagents Investigative techniques, diagnostic techniques (general aspects) Kinetics Medical sciences Microscopy, Fluorescence Miscellaneous. Technology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pituitary Neoplasms - metabolism Pituitary Neoplasms - pathology Rats Zinc - metabolism
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Zusammenfassung:	The synthesis of a coumarin-cyclen conjugate-based zinc-specific chemosensor and its ability to sense Zn 2+ in vitro is described. Using fluorescence microscopy, the chemosensor was shown to be capable of imaging Zn 2+ in live rat pituitary tumour cells. Graphic
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(03)00464-5