Analytical Solution to the Kinetics of Breakable Filament Assembly

We present an analytical treatment of a set of coupled kinetic equations that governs the self-assembly of filamentous molecular structures. Application to the case of protein aggregation demonstrates that the kinetics of amyloid growth can often be dominated by secondary rather than by primary nucl...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2009-12, Vol.326 (5959), p.1533-1537
Hauptverfasser:	Knowles, Tuomas P.J, Waudby, Christopher A, Devlin, Glyn L, Cohen, Samuel I.A, Aguzzi, Adriano, Vendruscolo, Michele, Terentjev, Eugene M, Welland, Mark E, Dobson, Christopher M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregation Amyloid - chemistry Amyloids Biochemical Phenomena Biological and medical sciences Fibers Fundamental and applied biological sciences. Psychology Glutathione Peroxidase - chemistry Insulin - chemistry Interactions. Associations Intermolecular phenomena Kinetics Lactoglobulins - chemistry Mathematical Concepts Molecular biology Molecular biophysics Molecular structure Monomers Multiprotein Complexes - chemistry Nucleation Peptide Termination Factors - chemistry Peptides - chemistry Polymerization Power laws Prions Prions - chemistry Protein Multimerization Proteins Saccharomyces cerevisiae Proteins - chemistry Self assembly Solar fibrils
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