Caspase-1, Caspase-8, and Calpain Are Dispensable for IL-33 Release by Macrophages

In addition to IL-1 and IL-18, IL-33 was recently identified as a member of the IL-1 cytokine family. rIL-33 can promote production of Th2-type cytokines by Th2 cells and mast cells in vitro. Administration of rIL-33 to mice results in increases in IgE secretion and eosinophilic inflammation. Howeve...

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Veröffentlicht in:	The Journal of immunology (1950) 2009-12, Vol.183 (12), p.7890-7897
Hauptverfasser:	Ohno, Tatsukuni, Oboki, Keisuke, Kajiwara, Naoki, Morii, Eiichi, Aozasa, Katsuyuki, Flavell, Richard A, Okumura, Ko, Saito, Hirohisa, Nakae, Susumu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - enzymology Bone Marrow Cells - immunology Bone Marrow Cells - secretion Calpain - physiology Caspase 1 - physiology Caspase 8 - physiology Cells, Cultured Dendritic Cells - enzymology Dendritic Cells - immunology Dendritic Cells - secretion Hypersensitivity - enzymology Hypersensitivity - immunology Hypersensitivity - pathology Inflammation Mediators - physiology Interleukin-33 Interleukins - physiology Interleukins - secretion Macrophages, Peritoneal - enzymology Macrophages, Peritoneal - immunology Macrophages, Peritoneal - pathology Macrophages, Peritoneal - secretion Mast Cells - enzymology Mast Cells - immunology Mast Cells - secretion Mice Mice, Inbred BALB C Mice, Knockout Spleen - cytology Spleen - enzymology Spleen - immunology
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