Activity of mecillinam against Escherichia coli resistant to third-generation cephalosporins
Objectives To assess the activity of mecillinam against two groups of Escherichia coli: (i) a selection of international isolates with mechanisms of resistance caused by the presence of defined β-lactamases; and (ii) isolates resistant to third-generation cephalosporins referred from across Wales. M...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 2010-01, Vol.65 (1), p.79-81 |
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| creator | Wootton, Mandy Walsh, Tim R. Macfarlane, Lorna Howe, Robin A. |
| description | Objectives To assess the activity of mecillinam against two groups of Escherichia coli: (i) a selection of international isolates with mechanisms of resistance caused by the presence of defined β-lactamases; and (ii) isolates resistant to third-generation cephalosporins referred from across Wales. Methods Antibiotic susceptibility testing with mecillinam, meropenem, amoxicillin, co-amoxiclav, cefotaxime, piperacillin/tazobactam, ciprofloxacin, nitrofurantoin, trimethoprim and gentamicin was performed using the BSAC agar dilution method against 30 international strains of E. coli with known β-lactamase presence. Antibiotic susceptibility testing with mecillinam using the same method was performed against 325 regional isolates of E. coli resistant to third-generation cephalosporins. Results The susceptibility results showed that the only antibiotics to which the 30 international isolates were consistently susceptible were mecillinam (100%) and meropenem (100%), irrespective of the presence of β-lactamases. Of the local isolates, 93.5% (304/325) were susceptible to mecillinam, having MICs |
| doi_str_mv | 10.1093/jac/dkp404 |
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Methods Antibiotic susceptibility testing with mecillinam, meropenem, amoxicillin, co-amoxiclav, cefotaxime, piperacillin/tazobactam, ciprofloxacin, nitrofurantoin, trimethoprim and gentamicin was performed using the BSAC agar dilution method against 30 international strains of E. coli with known β-lactamase presence. Antibiotic susceptibility testing with mecillinam using the same method was performed against 325 regional isolates of E. coli resistant to third-generation cephalosporins. Results The susceptibility results showed that the only antibiotics to which the 30 international isolates were consistently susceptible were mecillinam (100%) and meropenem (100%), irrespective of the presence of β-lactamases. Of the local isolates, 93.5% (304/325) were susceptible to mecillinam, having MICs < 8 mg/L. Conclusions Our results show that mecillinam has excellent in vitro activity against a range of E. coli exhibiting β-lactamase activity, some with the production of multiple β-lactamases. It is time to further evaluate the clinical utility of mecillinam in the treatment of infections caused by such organisms.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/dkp404</identifier><identifier>PMID: 19915068</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Amdinocillin - pharmacology ; Anti-Bacterial Agents - pharmacology ; Antibiotics ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; beta-Lactamases - biosynthesis ; Biological and medical sciences ; Cephalosporins - pharmacology ; Drug Resistance, Bacterial ; E coli ; ESBLs ; Escherichia coli ; Escherichia coli - drug effects ; Escherichia coli - enzymology ; Escherichia coli - isolation & purification ; Escherichia coli Infections - microbiology ; Humans ; Infections ; Medical sciences ; Medical treatment ; Microbial Sensitivity Tests ; Pharmacology. Drug treatments ; resistance ; susceptibilities ; Wales</subject><ispartof>Journal of antimicrobial chemotherapy, 2010-01, Vol.65 (1), p.79-81</ispartof><rights>The Author 2009. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org 2010</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Oxford Publishing Limited(England) Jan 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-4c5dc8754f992f0b212289084f833c8bbf0d486410fdac8618e4fd6170567a053</citedby><cites>FETCH-LOGICAL-c441t-4c5dc8754f992f0b212289084f833c8bbf0d486410fdac8618e4fd6170567a053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1580,4011,27905,27906,27907</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22532933$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19915068$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wootton, Mandy</creatorcontrib><creatorcontrib>Walsh, Tim R.</creatorcontrib><creatorcontrib>Macfarlane, Lorna</creatorcontrib><creatorcontrib>Howe, Robin A.</creatorcontrib><title>Activity of mecillinam against Escherichia coli resistant to third-generation cephalosporins</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>Objectives To assess the activity of mecillinam against two groups of Escherichia coli: (i) a selection of international isolates with mechanisms of resistance caused by the presence of defined β-lactamases; and (ii) isolates resistant to third-generation cephalosporins referred from across Wales. Methods Antibiotic susceptibility testing with mecillinam, meropenem, amoxicillin, co-amoxiclav, cefotaxime, piperacillin/tazobactam, ciprofloxacin, nitrofurantoin, trimethoprim and gentamicin was performed using the BSAC agar dilution method against 30 international strains of E. coli with known β-lactamase presence. Antibiotic susceptibility testing with mecillinam using the same method was performed against 325 regional isolates of E. coli resistant to third-generation cephalosporins. Results The susceptibility results showed that the only antibiotics to which the 30 international isolates were consistently susceptible were mecillinam (100%) and meropenem (100%), irrespective of the presence of β-lactamases. Of the local isolates, 93.5% (304/325) were susceptible to mecillinam, having MICs < 8 mg/L. Conclusions Our results show that mecillinam has excellent in vitro activity against a range of E. coli exhibiting β-lactamase activity, some with the production of multiple β-lactamases. It is time to further evaluate the clinical utility of mecillinam in the treatment of infections caused by such organisms.</description><subject>Amdinocillin - pharmacology</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>beta-Lactamases - biosynthesis</subject><subject>Biological and medical sciences</subject><subject>Cephalosporins - pharmacology</subject><subject>Drug Resistance, Bacterial</subject><subject>E coli</subject><subject>ESBLs</subject><subject>Escherichia coli</subject><subject>Escherichia coli - drug effects</subject><subject>Escherichia coli - enzymology</subject><subject>Escherichia coli - isolation & purification</subject><subject>Escherichia coli Infections - microbiology</subject><subject>Humans</subject><subject>Infections</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Microbial Sensitivity Tests</subject><subject>Pharmacology. Drug treatments</subject><subject>resistance</subject><subject>susceptibilities</subject><subject>Wales</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90U1rFDEYB_Agit1WL34ACYIKwti8vxxLrVYoeFBRRAjZTNLNdmYyJpliv70pu7Tgoadcfnne_gC8wOg9Rpoeb6077q9mhtgjsMJMoI4gjR-DFaKId5JxegAOS9kihAQX6ik4wFpjjoRagd8nrsbrWG9gCnD0Lg5DnOwI7aWNU6nwrLiNz9FtooUuDRFmX2KpdqqwJlg3MffdpZ98tjWmCTo_b-yQypxy-_4MPAl2KP75_j0C3z-efTs97y6-fPp8enLROcZw7ZjjvVOSs6A1CWhNMCFKI8WCotSp9TqgninBMAq9dUpg5VnoBZaIC2kRp0fg7a7unNOfxZdqxlicHwY7-bQUIynDmhOsmnzzoGytZTsOafDVf3Cbljy1LZqRQlIpdUPvdsjlVEr2wcw5jjbfGIzMbTSmRWN20TT8cl9xWY--v6f7LBp4vQe2ODuEbCcXy50jhFOiKb13aZkfbtjtXMvL_72TNl-Z2_m5Of_5y_zQ8ivTRJgP9B_j0bJh</recordid><startdate>201001</startdate><enddate>201001</enddate><creator>Wootton, Mandy</creator><creator>Walsh, Tim R.</creator><creator>Macfarlane, Lorna</creator><creator>Howe, Robin A.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201001</creationdate><title>Activity of mecillinam against Escherichia coli resistant to third-generation cephalosporins</title><author>Wootton, Mandy ; Walsh, Tim R. ; Macfarlane, Lorna ; Howe, Robin A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-4c5dc8754f992f0b212289084f833c8bbf0d486410fdac8618e4fd6170567a053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Amdinocillin - pharmacology</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>beta-Lactamases - biosynthesis</topic><topic>Biological and medical sciences</topic><topic>Cephalosporins - pharmacology</topic><topic>Drug Resistance, Bacterial</topic><topic>E coli</topic><topic>ESBLs</topic><topic>Escherichia coli</topic><topic>Escherichia coli - drug effects</topic><topic>Escherichia coli - enzymology</topic><topic>Escherichia coli - isolation & purification</topic><topic>Escherichia coli Infections - microbiology</topic><topic>Humans</topic><topic>Infections</topic><topic>Medical sciences</topic><topic>Medical treatment</topic><topic>Microbial Sensitivity Tests</topic><topic>Pharmacology. Drug treatments</topic><topic>resistance</topic><topic>susceptibilities</topic><topic>Wales</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wootton, Mandy</creatorcontrib><creatorcontrib>Walsh, Tim R.</creatorcontrib><creatorcontrib>Macfarlane, Lorna</creatorcontrib><creatorcontrib>Howe, Robin A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wootton, Mandy</au><au>Walsh, Tim R.</au><au>Macfarlane, Lorna</au><au>Howe, Robin A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activity of mecillinam against Escherichia coli resistant to third-generation cephalosporins</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>2010-01</date><risdate>2010</risdate><volume>65</volume><issue>1</issue><spage>79</spage><epage>81</epage><pages>79-81</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><coden>JACHDX</coden><abstract>Objectives To assess the activity of mecillinam against two groups of Escherichia coli: (i) a selection of international isolates with mechanisms of resistance caused by the presence of defined β-lactamases; and (ii) isolates resistant to third-generation cephalosporins referred from across Wales. Methods Antibiotic susceptibility testing with mecillinam, meropenem, amoxicillin, co-amoxiclav, cefotaxime, piperacillin/tazobactam, ciprofloxacin, nitrofurantoin, trimethoprim and gentamicin was performed using the BSAC agar dilution method against 30 international strains of E. coli with known β-lactamase presence. Antibiotic susceptibility testing with mecillinam using the same method was performed against 325 regional isolates of E. coli resistant to third-generation cephalosporins. Results The susceptibility results showed that the only antibiotics to which the 30 international isolates were consistently susceptible were mecillinam (100%) and meropenem (100%), irrespective of the presence of β-lactamases. Of the local isolates, 93.5% (304/325) were susceptible to mecillinam, having MICs < 8 mg/L. Conclusions Our results show that mecillinam has excellent in vitro activity against a range of E. coli exhibiting β-lactamase activity, some with the production of multiple β-lactamases. It is time to further evaluate the clinical utility of mecillinam in the treatment of infections caused by such organisms.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>19915068</pmid><doi>10.1093/jac/dkp404</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amdinocillin - pharmacology Anti-Bacterial Agents - pharmacology Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents beta-Lactamases - biosynthesis Biological and medical sciences Cephalosporins - pharmacology Drug Resistance, Bacterial E coli ESBLs Escherichia coli Escherichia coli - drug effects Escherichia coli - enzymology Escherichia coli - isolation & purification Escherichia coli Infections - microbiology Humans Infections Medical sciences Medical treatment Microbial Sensitivity Tests Pharmacology. Drug treatments resistance susceptibilities Wales |
| title | Activity of mecillinam against Escherichia coli resistant to third-generation cephalosporins |
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