Inhibition of Acidic Mammalian Chitinase by RNA Interference Suppresses Ovalbumin-Sensitized Allergic Asthma

Asthma, a chronic helper T cell type 2-mediated inflammatory disease, is characterized by airway hyperresponsiveness and inflammation. Growing evidence suggests that increased expression of acidic mammalian chitinase (AMCase) may play a role in the pathogenesis of asthma. In the present study, we so...

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Veröffentlicht in:	Human gene therapy 2009-12, Vol.20 (12), p.1597-1606
Hauptverfasser:	YANG, Ching-Jen, LIU, Yu-Kuo, LIU, Chao-Lin, SHEN, Chia-Ning, KUO, Ming-Ling, SU, Chien-Chang, TSENG, Ching-Ping, YEN, Tzu-Chen, SHEN, Chia-Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Adeno-associated virus Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Asthma - immunology Asthma - pathology Asthma - therapy Biological and medical sciences Biotechnology Chitinases - antagonists & inhibitors Chitinases - genetics Disease Models, Animal Female Fundamental and applied biological sciences. Psychology Gene therapy Genetic Therapy - methods Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects Medical sciences Mice Mice, Inbred BALB C Ovalbumin - immunology RNA Interference Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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