Extensive Involvement of the Gastrointestinal Tract by a de novo Presentation of the Monoblastic Type of Myeloid Sarcoma: A Case Report of a Rare Entity That is Often Misdiagnosed
We present the first known case of the monoblastic type of myeloid sarcoma (also known as extramedullary myeloid tumor, chloroma, and granulocytic sarcoma) with diffuse involvement of the gastrointestinal tract. The patient originally presented with diarrhea and crampy abdominal discomfort. Endoscop...
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| Veröffentlicht in: | The American journal of the medical sciences 2009-12, Vol.338 (6), p.513-516 |
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| creator | Holloman, David Eberts, Paul Lewin, David Lazarchick, John Clark, Christian Comerford, Lawrence Stuart, Robert |
| description | We present the first known case of the monoblastic type of myeloid sarcoma (also known as extramedullary myeloid tumor, chloroma, and granulocytic sarcoma) with diffuse involvement of the gastrointestinal tract. The patient originally presented with diarrhea and crampy abdominal discomfort. Endoscopically, the disease showed a diffuse inflammatory process mimicking a number of benign conditions, such as inflammatory bowel disease and autoimmune enteropathy. Sequential biopsies of the upper and lower gastrointestinal tract showed a diffuse infiltrate of increasingly atypical cells. The disease progressed to systemic involvement, including widespread lymphadenopathy, splenomegaly, and pulmonary deposits; the patient died 13months after the development of initial symptoms. The immunohistochemical and histologic profiles of this case are diagnostic of the monoblastic type of myeloid sarcoma. |
| doi_str_mv | 10.1097/MAJ.0b013e3181b26fa9 |
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The patient originally presented with diarrhea and crampy abdominal discomfort. Endoscopically, the disease showed a diffuse inflammatory process mimicking a number of benign conditions, such as inflammatory bowel disease and autoimmune enteropathy. Sequential biopsies of the upper and lower gastrointestinal tract showed a diffuse infiltrate of increasingly atypical cells. The disease progressed to systemic involvement, including widespread lymphadenopathy, splenomegaly, and pulmonary deposits; the patient died 13months after the development of initial symptoms. The immunohistochemical and histologic profiles of this case are diagnostic of the monoblastic type of myeloid sarcoma.</description><identifier>ISSN: 0002-9629</identifier><identifier>EISSN: 1538-2990</identifier><identifier>DOI: 10.1097/MAJ.0b013e3181b26fa9</identifier><identifier>PMID: 20010158</identifier><identifier>CODEN: AJMSA9</identifier><language>eng</language><publisher>Hagerstown, MD: Elsevier Inc</publisher><subject>Biological and medical sciences ; Chloroma ; Diagnosis, Differential ; Extramedullary myeloid tumor ; Female ; Gastrointestinal ; Gastrointestinal Neoplasms - diagnosis ; Gastrointestinal Neoplasms - pathology ; Gastrointestinal Tract - pathology ; General aspects ; Granulocyte Precursor Cells - pathology ; Granulocytic sarcoma ; Hematologic and hematopoietic diseases ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Medical sciences ; Middle Aged ; Myeloid sarcoma ; Sarcoma, Myeloid - diagnosis ; Sarcoma, Myeloid - pathology</subject><ispartof>The American journal of the medical sciences, 2009-12, Vol.338 (6), p.513-516</ispartof><rights>2009 Southern Society for Clinical Investigation</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-737fc40e41ccd395b3dc788a29e9a1fe5e83a24d9cb4e08573ddd16e35494b473</citedby><cites>FETCH-LOGICAL-c391t-737fc40e41ccd395b3dc788a29e9a1fe5e83a24d9cb4e08573ddd16e35494b473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22235260$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20010158$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holloman, David</creatorcontrib><creatorcontrib>Eberts, Paul</creatorcontrib><creatorcontrib>Lewin, David</creatorcontrib><creatorcontrib>Lazarchick, John</creatorcontrib><creatorcontrib>Clark, Christian</creatorcontrib><creatorcontrib>Comerford, Lawrence</creatorcontrib><creatorcontrib>Stuart, Robert</creatorcontrib><title>Extensive Involvement of the Gastrointestinal Tract by a de novo Presentation of the Monoblastic Type of Myeloid Sarcoma: A Case Report of a Rare Entity That is Often Misdiagnosed</title><title>The American journal of the medical sciences</title><addtitle>Am J Med Sci</addtitle><description>We present the first known case of the monoblastic type of myeloid sarcoma (also known as extramedullary myeloid tumor, chloroma, and granulocytic sarcoma) with diffuse involvement of the gastrointestinal tract. The patient originally presented with diarrhea and crampy abdominal discomfort. Endoscopically, the disease showed a diffuse inflammatory process mimicking a number of benign conditions, such as inflammatory bowel disease and autoimmune enteropathy. Sequential biopsies of the upper and lower gastrointestinal tract showed a diffuse infiltrate of increasingly atypical cells. The disease progressed to systemic involvement, including widespread lymphadenopathy, splenomegaly, and pulmonary deposits; the patient died 13months after the development of initial symptoms. The immunohistochemical and histologic profiles of this case are diagnostic of the monoblastic type of myeloid sarcoma.</description><subject>Biological and medical sciences</subject><subject>Chloroma</subject><subject>Diagnosis, Differential</subject><subject>Extramedullary myeloid tumor</subject><subject>Female</subject><subject>Gastrointestinal</subject><subject>Gastrointestinal Neoplasms - diagnosis</subject><subject>Gastrointestinal Neoplasms - pathology</subject><subject>Gastrointestinal Tract - pathology</subject><subject>General aspects</subject><subject>Granulocyte Precursor Cells - pathology</subject><subject>Granulocytic sarcoma</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myeloid sarcoma</subject><subject>Sarcoma, Myeloid - diagnosis</subject><subject>Sarcoma, Myeloid - pathology</subject><issn>0002-9629</issn><issn>1538-2990</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1uEzEURkcIREPhDRC6G8QqxT8zmTELpCgKpahRUQnr0R37DjWa2KntRMxz8YI4JAWJBStb1jn-ru5XFC85u-BM1W9X808XrGNckuQN78SsR_WomPBKNlOhFHtcTBhjYqpmQp0Vz2L8zhgXDZdPizORr4xXzaT4ufyRyEW7J7hyez_saUMuge8h3RFcYkzBW5coJutwgHVAnaAbAcEQOL_38DlQzAom692Dt_LOd0OWrYb1uKXD-2qkwVsDXzBov8F3MIcFRoJb2vrwOxHhFgPB0iWbRljfYQIb4abPA8LKRmPxm_ORzPPiSY9DpBen87z4-mG5XnycXt9cXi3m11MtFU_TWta9LhmVXGsjVdVJo-umQaFIIe-pokaiKI3SXUmsqWppjOEzklWpyq6s5Xnx5vjvNvj7XV5Bu7FR0zCgI7-LbS1LroSQVSbLI6mDjzFQ326D3WAYW87aQ1ttbqv9t62svToF7LoNmT_SQz0ZeH0CMGoc-oBO2_iXO4SLGcvc-yNHeR17S6GN2pLTZGwgnVrj7f8n-QVTibVW</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Holloman, David</creator><creator>Eberts, Paul</creator><creator>Lewin, David</creator><creator>Lazarchick, John</creator><creator>Clark, Christian</creator><creator>Comerford, Lawrence</creator><creator>Stuart, Robert</creator><general>Elsevier Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091201</creationdate><title>Extensive Involvement of the Gastrointestinal Tract by a de novo Presentation of the Monoblastic Type of Myeloid Sarcoma: A Case Report of a Rare Entity That is Often Misdiagnosed</title><author>Holloman, David ; Eberts, Paul ; Lewin, David ; Lazarchick, John ; Clark, Christian ; Comerford, Lawrence ; Stuart, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-737fc40e41ccd395b3dc788a29e9a1fe5e83a24d9cb4e08573ddd16e35494b473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biological and medical sciences</topic><topic>Chloroma</topic><topic>Diagnosis, Differential</topic><topic>Extramedullary myeloid tumor</topic><topic>Female</topic><topic>Gastrointestinal</topic><topic>Gastrointestinal Neoplasms - diagnosis</topic><topic>Gastrointestinal Neoplasms - pathology</topic><topic>Gastrointestinal Tract - pathology</topic><topic>General aspects</topic><topic>Granulocyte Precursor Cells - pathology</topic><topic>Granulocytic sarcoma</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myeloid sarcoma</topic><topic>Sarcoma, Myeloid - diagnosis</topic><topic>Sarcoma, Myeloid - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holloman, David</creatorcontrib><creatorcontrib>Eberts, Paul</creatorcontrib><creatorcontrib>Lewin, David</creatorcontrib><creatorcontrib>Lazarchick, John</creatorcontrib><creatorcontrib>Clark, Christian</creatorcontrib><creatorcontrib>Comerford, Lawrence</creatorcontrib><creatorcontrib>Stuart, Robert</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of the medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holloman, David</au><au>Eberts, Paul</au><au>Lewin, David</au><au>Lazarchick, John</au><au>Clark, Christian</au><au>Comerford, Lawrence</au><au>Stuart, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extensive Involvement of the Gastrointestinal Tract by a de novo Presentation of the Monoblastic Type of Myeloid Sarcoma: A Case Report of a Rare Entity That is Often Misdiagnosed</atitle><jtitle>The American journal of the medical sciences</jtitle><addtitle>Am J Med Sci</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>338</volume><issue>6</issue><spage>513</spage><epage>516</epage><pages>513-516</pages><issn>0002-9629</issn><eissn>1538-2990</eissn><coden>AJMSA9</coden><abstract>We present the first known case of the monoblastic type of myeloid sarcoma (also known as extramedullary myeloid tumor, chloroma, and granulocytic sarcoma) with diffuse involvement of the gastrointestinal tract. The patient originally presented with diarrhea and crampy abdominal discomfort. Endoscopically, the disease showed a diffuse inflammatory process mimicking a number of benign conditions, such as inflammatory bowel disease and autoimmune enteropathy. Sequential biopsies of the upper and lower gastrointestinal tract showed a diffuse infiltrate of increasingly atypical cells. The disease progressed to systemic involvement, including widespread lymphadenopathy, splenomegaly, and pulmonary deposits; the patient died 13months after the development of initial symptoms. The immunohistochemical and histologic profiles of this case are diagnostic of the monoblastic type of myeloid sarcoma.</abstract><cop>Hagerstown, MD</cop><pub>Elsevier Inc</pub><pmid>20010158</pmid><doi>10.1097/MAJ.0b013e3181b26fa9</doi><tpages>4</tpages></addata></record> |
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| subjects | Biological and medical sciences Chloroma Diagnosis, Differential Extramedullary myeloid tumor Female Gastrointestinal Gastrointestinal Neoplasms - diagnosis Gastrointestinal Neoplasms - pathology Gastrointestinal Tract - pathology General aspects Granulocyte Precursor Cells - pathology Granulocytic sarcoma Hematologic and hematopoietic diseases Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Middle Aged Myeloid sarcoma Sarcoma, Myeloid - diagnosis Sarcoma, Myeloid - pathology |
| title | Extensive Involvement of the Gastrointestinal Tract by a de novo Presentation of the Monoblastic Type of Myeloid Sarcoma: A Case Report of a Rare Entity That is Often Misdiagnosed |
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