The ANKK1 Gene Associated with Addictions Is Expressed in Astroglial Cells and Upregulated by Apomorphine

Background Taq IA, the most widely analyzed genetic polymorphism in addictions, has traditionally been considered a gene marker for association with D2 dopamine receptor gene ( DRD2 ). Taq IA is located in the coding region of the ANKK1 gene that overlaps DRD2 and encodes a predicted kinase ANKK1. T...

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Veröffentlicht in:	Biological psychiatry (1969) 2010, Vol.67 (1), p.3-11
Hauptverfasser:	Hoenicka, Janet, Quiñones-Lombraña, Adolfo, España-Serrano, Laura, Alvira-Botero, Ximena, Kremer, Leonor, Pérez-González, Rocío, Rodríguez-Jiménez, Roberto, Jiménez-Arriero, Miguel Ángel, Ponce, Guillermo, Palomo, Tomás
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictions Animals ANKK1 Apomorphine - pharmacology astrocytes Astrocytes - drug effects astroglia Biological and medical sciences Cells, Cultured Central Nervous System - cytology Central Nervous System - metabolism Dopamine Agonists - pharmacology DRD2 Embryo, Mammalian Glioma Humans Medical sciences Mice Mice, Inbred BALB C Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neuroblastoma polymorphism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry radial glia Rats Rats, Wistar Receptors, Dopamine D2 - genetics Receptors, Dopamine D2 - metabolism Sequence Alignment - methods Sequence Analysis, Protein Substance-Related Disorders - genetics Sulpiride - pharmacology TaqIA Tretinoin - pharmacology Up-Regulation - drug effects
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