Mathematical simulation of pseudo-crystallofermentation of hydrocortisone by Arthrobacter simplex
A mathematical model has been developed to simulate the pseudo‐crystallofermentation process of hydrocortisone by Arthrobacter simplex. The model describing the process included considerations on the kinetics of microbial growth, the rate of enzyme formation, the rate of substrate dissolution, the r...
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| Veröffentlicht in: | Biotechnology and bioengineering 1985-03, Vol.27 (3), p.253-259 |
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| container_title | Biotechnology and bioengineering |
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| creator | Chen, Kuo-Cheng Chang, Ching-Chuan Chiu, Chuang-Fan Ling, Alvin C. |
| description | A mathematical model has been developed to simulate the pseudo‐crystallofermentation process of hydrocortisone by Arthrobacter simplex. The model describing the process included considerations on the kinetics of microbial growth, the rate of enzyme formation, the rate of substrate dissolution, the rate of solute crystallization, and the kinetics of enzymatic reaction. The system of equations was solved numerically by the Runge‐Kutta‐Gill method. The good agreement between prediction and experiment indicated the reliability of the established model. The simulation was capable of predicting the time when the crystallization of product occurred, which could be further verified by microscopic observation on the culture medium, as well as cell growth, enzyme synthesis, product formation, and the composition of the final product crystals. |
| doi_str_mv | 10.1002/bit.260270307 |
| format | Article |
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The model describing the process included considerations on the kinetics of microbial growth, the rate of enzyme formation, the rate of substrate dissolution, the rate of solute crystallization, and the kinetics of enzymatic reaction. The system of equations was solved numerically by the Runge‐Kutta‐Gill method. The good agreement between prediction and experiment indicated the reliability of the established model. The simulation was capable of predicting the time when the crystallization of product occurred, which could be further verified by microscopic observation on the culture medium, as well as cell growth, enzyme synthesis, product formation, and the composition of the final product crystals.</description><identifier>ISSN: 0006-3592</identifier><identifier>EISSN: 1097-0290</identifier><identifier>DOI: 10.1002/bit.260270307</identifier><identifier>PMID: 18553666</identifier><identifier>CODEN: BIBIAU</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Arthrobacter simplex ; Bioconversions. Hemisynthesis ; Biological and medical sciences ; Biotechnology ; crystallization ; fermentation ; Fundamental and applied biological sciences. Psychology ; hydrocortisone ; Methods. Procedures. Technologies ; prednisolone</subject><ispartof>Biotechnology and bioengineering, 1985-03, Vol.27 (3), p.253-259</ispartof><rights>Copyright © 1985 John Wiley & Sons, Inc.</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4727-ab3861d8c29203de394fcbee78ace20ecc8c63a53ff2c3838438e40df9dc063d3</citedby><cites>FETCH-LOGICAL-c4727-ab3861d8c29203de394fcbee78ace20ecc8c63a53ff2c3838438e40df9dc063d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbit.260270307$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbit.260270307$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9189372$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18553666$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Kuo-Cheng</creatorcontrib><creatorcontrib>Chang, Ching-Chuan</creatorcontrib><creatorcontrib>Chiu, Chuang-Fan</creatorcontrib><creatorcontrib>Ling, Alvin C.</creatorcontrib><title>Mathematical simulation of pseudo-crystallofermentation of hydrocortisone by Arthrobacter simplex</title><title>Biotechnology and bioengineering</title><addtitle>Biotechnol. Bioeng</addtitle><description>A mathematical model has been developed to simulate the pseudo‐crystallofermentation process of hydrocortisone by Arthrobacter simplex. The model describing the process included considerations on the kinetics of microbial growth, the rate of enzyme formation, the rate of substrate dissolution, the rate of solute crystallization, and the kinetics of enzymatic reaction. The system of equations was solved numerically by the Runge‐Kutta‐Gill method. The good agreement between prediction and experiment indicated the reliability of the established model. The simulation was capable of predicting the time when the crystallization of product occurred, which could be further verified by microscopic observation on the culture medium, as well as cell growth, enzyme synthesis, product formation, and the composition of the final product crystals.</description><subject>Arthrobacter simplex</subject><subject>Bioconversions. Hemisynthesis</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>crystallization</subject><subject>fermentation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>hydrocortisone</subject><subject>Methods. Procedures. Technologies</subject><subject>prednisolone</subject><issn>0006-3592</issn><issn>1097-0290</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><recordid>eNp90DFv1DAUB3ALgei1MLKiDIhOKc92YjtjqaBUaoHhgNFynBddwIkP2xHNt8fVRQdTJ9vyz-89_wl5ReGCArB37ZAumAAmgYN8QjYUGlkCa-Ap2QCAKHndsBNyGuPPfJRKiOfkhKq65kKIDTF3Ju1wNGmwxhVxGGeX934qfF_sI86dL21YYjLO-R7DiFM63u-WLnjrQxqin7Bol-IypF3wrbEJw0OxvcP7F-RZb1zEl-t6Rr59_LC9-lTefrm-ubq8LW0lmSxNy5WgnbKsYcA75E3V2xZRKmORAVqrrOCm5n3PLFdcVVxhBV3fdBYE7_gZOT_U3Qf_e8aY9DhEi86ZCf0cteRV_nbVyCzfPippRaGuVJ1heYA2-BgD9nofhtGERVPQD-nrnL4-pp_967Xw3I7Y_dNr3Bm8WYGJOe8-mMkO8egaqhouWWbywP4MDpfHm-r3N9v_J1gnHmLC--NLE35pIbms9Y_P11p9BXmntrX-zv8Cm6OusQ</recordid><startdate>198503</startdate><enddate>198503</enddate><creator>Chen, Kuo-Cheng</creator><creator>Chang, Ching-Chuan</creator><creator>Chiu, Chuang-Fan</creator><creator>Ling, Alvin C.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7SQ</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>198503</creationdate><title>Mathematical simulation of pseudo-crystallofermentation of hydrocortisone by Arthrobacter simplex</title><author>Chen, Kuo-Cheng ; Chang, Ching-Chuan ; Chiu, Chuang-Fan ; Ling, Alvin C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4727-ab3861d8c29203de394fcbee78ace20ecc8c63a53ff2c3838438e40df9dc063d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Arthrobacter simplex</topic><topic>Bioconversions. Hemisynthesis</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>crystallization</topic><topic>fermentation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>hydrocortisone</topic><topic>Methods. Procedures. Technologies</topic><topic>prednisolone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Kuo-Cheng</creatorcontrib><creatorcontrib>Chang, Ching-Chuan</creatorcontrib><creatorcontrib>Chiu, Chuang-Fan</creatorcontrib><creatorcontrib>Ling, Alvin C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Endocrinology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biotechnology and bioengineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Kuo-Cheng</au><au>Chang, Ching-Chuan</au><au>Chiu, Chuang-Fan</au><au>Ling, Alvin C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mathematical simulation of pseudo-crystallofermentation of hydrocortisone by Arthrobacter simplex</atitle><jtitle>Biotechnology and bioengineering</jtitle><addtitle>Biotechnol. Bioeng</addtitle><date>1985-03</date><risdate>1985</risdate><volume>27</volume><issue>3</issue><spage>253</spage><epage>259</epage><pages>253-259</pages><issn>0006-3592</issn><eissn>1097-0290</eissn><coden>BIBIAU</coden><abstract>A mathematical model has been developed to simulate the pseudo‐crystallofermentation process of hydrocortisone by Arthrobacter simplex. The model describing the process included considerations on the kinetics of microbial growth, the rate of enzyme formation, the rate of substrate dissolution, the rate of solute crystallization, and the kinetics of enzymatic reaction. The system of equations was solved numerically by the Runge‐Kutta‐Gill method. The good agreement between prediction and experiment indicated the reliability of the established model. The simulation was capable of predicting the time when the crystallization of product occurred, which could be further verified by microscopic observation on the culture medium, as well as cell growth, enzyme synthesis, product formation, and the composition of the final product crystals.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>18553666</pmid><doi>10.1002/bit.260270307</doi><tpages>7</tpages></addata></record> |
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| issn | 0006-3592 1097-0290 |
| language | eng |
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| subjects | Arthrobacter simplex Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology crystallization fermentation Fundamental and applied biological sciences. Psychology hydrocortisone Methods. Procedures. Technologies prednisolone |
| title | Mathematical simulation of pseudo-crystallofermentation of hydrocortisone by Arthrobacter simplex |
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