TbMP57 Is a 3′ Terminal Uridylyl Transferase (TUTase) of the Trypanosoma brucei Editosome

RNA editing produces mature trypanosome mitochondrial mRNAs by uridylate (U) insertion and deletion. In insertion editing, Us are added to the pre-mRNA by a 3′ terminal uridylyl transferase (TUTase) activity. We report the identification of a TUTase activity that copurifies with in vitro editing and...

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Veröffentlicht in:	Molecular cell 2003-06, Vol.11 (6), p.1525-1536
Hauptverfasser:	Ernst, Nancy Lewis, Panicucci, Brian, Igo, Robert P, Panigrahi, Aswini K, Salavati, Reza, Stuart, Kenneth
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Catalysis Chromatography, Agarose Chromatography, Gel Chromatography, Ion Exchange Mitochondria - chemistry Mitochondria - enzymology Molecular Sequence Data Molecular Weight Protein Structure, Tertiary Protozoan Proteins Recombinant Proteins - metabolism Ribonucleoproteins - metabolism RNA - genetics RNA - metabolism RNA Editing RNA Precursors - genetics RNA Precursors - metabolism RNA, Guide - chemistry RNA, Guide - genetics RNA, Guide - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Substrate Specificity Trypanosoma brucei brucei - cytology Trypanosoma brucei brucei - enzymology Trypanosoma brucei brucei - genetics UDPglucose-Hexose-1-Phosphate Uridylyltransferase - genetics UDPglucose-Hexose-1-Phosphate Uridylyltransferase - isolation & purification UDPglucose-Hexose-1-Phosphate Uridylyltransferase - metabolism
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