Subcutaneous inoculation of a whole virus particle vaccine prepared from a non-pathogenic virus library induces protective immunity against H7N7 highly pathogenic avian influenza virus in cynomolgus macaques

Abstract Development of H7N7 highly pathogenic avian influenza virus (HPAIV) vaccines is an urgent issue since human cases of infection with this subtype virus have been reported and most humans have no immunity against H7N7 viruses. We made an H7N7 vaccine combining components from an influenza vir...

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Veröffentlicht in:	Vaccine 2010-01, Vol.28 (3), p.780-789
Hauptverfasser:	Itoh, Yasushi, Ozaki, Hiroichi, Ishigaki, Hirohito, Sakoda, Yoshihiro, Nagata, Tomoya, Soda, Kosuke, Isoda, Norikazu, Miyake, Taichiro, Ishida, Hideaki, Okamoto, Kiyoko, Nakayama, Misako, Tsuchiya, Hideaki, Torii, Ryuzo, Kida, Hiroshi, Ogasawara, Kazumasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Adjuvants, Immunologic - administration & dosage Allergy and Immunology Alum Compounds - administration & dosage Aluminum sulfate Animals Antibodies Antibodies, Viral - analysis Antibodies, Viral - blood Applied microbiology Avian influenza virus Biological and medical sciences Body temperature CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell Proliferation Cynomolgus Fever Fowl plague Fundamental and applied biological sciences. Psychology H7N7 Highly pathogenic avian influenza virus Immunity Immunoglobulin A - analysis Immunoglobulin A - blood Immunoglobulin G - analysis Immunoglobulin G - blood Immunologic Memory Infection Infections Influenza A Virus, H7N7 Subtype - immunology Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Influenza virus Injections, Subcutaneous Inoculation Laboratories Lymphocytes T Macaca Macaca fascicularis Microbiology Miscellaneous Nasal Cavity - immunology Nasal Cavity - virology Non-human primate Orthomyxoviridae Infections - pathology Orthomyxoviridae Infections - prevention & control Poultry Taxonomy Time Factors Trachea - immunology Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Virology Viruses
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