Treatment of resistant obsessive-compulsive disorder with ventral capsular/ventral striatal gamma capsulotomy: a pilot prospective study

A subgroup of obsessive-compulsive disorder (OCD) patients remains refractory to conventional treatments. For them, a new stereotactic radiosurgery has been recently developed: the ventral capsular/ventral striatal (VC/VS) gamma capsulotomy. The authors aim to report efficacy and adverse events of V...

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Veröffentlicht in:The journal of neuropsychiatry and clinical neurosciences 2009-09, Vol.21 (4), p.381-392
Hauptverfasser: Lopes, Antonio Carlos, Greenberg, Benjamin D, Norén, Georg, Canteras, Miguel Montes, Busatto, Geraldo F, de Mathis, Maria Eugênia, Taub, Anita, D'Alcante, Carina Chaubet, Hoexter, Marcelo Queiroz, Gouvea, Fernando Sauerbronn, Cecconi, Janaína Philippi, Gentil, André F, Ferrão, Ygor Arzeno, Fuentes, Daniel, de Castro, Cláudio Campi, Leite, Cláudia C, Salvajoli, João Victor, Duran, Fábio L S, Rasmussen, Steven, Miguel, Eurípedes Constantino
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Sprache:eng
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Zusammenfassung:A subgroup of obsessive-compulsive disorder (OCD) patients remains refractory to conventional treatments. For them, a new stereotactic radiosurgery has been recently developed: the ventral capsular/ventral striatal (VC/VS) gamma capsulotomy. The authors aim to report efficacy and adverse events of VC/VS gamma capsulotomy. Five refractory OCD patients were selected. The authors assessed OCD, anxiety and depressive symptoms, and side effects pre- and postoperatively. Three patients (60%) met response criteria 48 months after surgery. Adverse effects were episodic and transient. Ventral capsular/ventral striatal gamma capsulotomy holds therapeutic promise, with few adverse effects.
ISSN:1545-7222
DOI:10.1176/appi.neuropsych.21.4.381