Contralateral Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

To estimate the risk for contralateral breast cancer in members of BRCA1- and BRCA2-positive families and to determine predictive risk factors. A retrospective, multicenter, cohort study was performed from 1996 until 2008 and comprised 2,020 women with unilateral breast cancer (index patients, n = 9...

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Veröffentlicht in:	Journal of clinical oncology 2009-12, Vol.27 (35), p.5887-5892
Hauptverfasser:	Graeser, Monika K, Engel, Christoph, Rhiem, Kerstin, Gadzicki, Dorothea, Bick, Ulrich, Kast, Karin, Froster, Ursula G, Schlehe, Bettina, Bechtold, Astrid, Arnold, Norbert, Preisler-Adams, Sabine, Nestle-Kraemling, Carolin, Zaino, Mohammad, Loeffler, Markus, Kiechle, Marion, Meindl, Alfons, Varga, Dominic, Schmutzler, Rita K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Apoptosis Regulatory Proteins BRCA1 Protein - genetics BRCA2 Protein - genetics Breast Neoplasms - genetics Breast Neoplasms - pathology Breast Neoplasms - therapy Female Gene Expression Regulation, Neoplastic Genetic Predisposition to Disease Germany Humans Kaplan-Meier Estimate Middle Aged Mutation Neoplasms, Second Primary Pedigree Proportional Hazards Models Retrospective Studies Risk Assessment Risk Factors Time Factors Treatment Outcome
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