Intracellular Processing of Proteins Mediated by Biodegradable Polyelectrolyte Capsules

Multilayer polyelectrolyte capsules made by layer-by-layer assembly of oppositely charged biodegradable polyelectrolytes were filled with a model of a nonactive prodrug, a self-quenched fluorescence-labeled protein. After capsule uptake by living cells, the walls of the capsules were actively degrad...

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Veröffentlicht in:	Nano letters 2009-12, Vol.9 (12), p.4398-4402
Hauptverfasser:	Rivera-Gil, Pilar, De Koker, Stefaan, De Geest, Bruno G, Parak, Wolfgang J
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Absorbable Implants Animals Capsules - chemical synthesis Catalytic methods Cross-disciplinary physics: materials science rheology Electrolytes - chemistry Exact sciences and technology Intracellular Fluid - metabolism Materials science Methods of nanofabrication Mice Ovalbumin - chemistry Ovalbumin - pharmacokinetics Physics Prodrugs - chemistry Prodrugs - pharmacokinetics
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