Carbohydrate-Dependent Signaling from the Phosphatidylglucoside-Based Microdomain Induces Granulocytic Differentiation of HL60 Cells

Glycosphingolipids form glycosphingolipid signaling microdomains. Here, we report an unrecognized type of phosphatidylglucoside (PhGlc)-based lipid microdomain in HL60 cells. Treatment of cells with rGL-7, which preferentially reacts with PhGlc, induced differentiation of HL60 cells. This was manife...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-06, Vol.100 (13), p.7454-7459
Hauptverfasser:	Nagatsuka, Yasuko, Hara-Yokoyama, Miki, Kasama, Takeshi, Takekoshi, Masataka, Maeda, Fumiko, Ihara, Seiji, Fujiwara, Shigeyoshi, Ohshima, Eriko, Ishii, Kumiko, Kobayashi, Toshihide, Shimizu, Kazufumi, Hirabayashi, Yoshio
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-ribosyl Cyclase - biosynthesis ADP-ribosyl Cyclase 1 Amino Acid Sequence Antibodies Antigens Antigens, CD - biosynthesis B lymphocytes beta-Cyclodextrins Biological Sciences Blood cells Carbohydrate Metabolism Carbohydrates Cell Differentiation Cell lines Cellular biology Cellular differentiation Cyclodextrins - metabolism Detergents - pharmacology Down-Regulation G(M1) Ganglioside - metabolism Gels Glucose Glycerophospholipids - chemistry Glycerophospholipids - metabolism Granulocytes - cytology HL-60 Cells Humans Immunoblotting Lipid Metabolism Lipids Membrane Glycoproteins Membrane Microdomains - metabolism Microscopy, Fluorescence Molecular Sequence Data Octoxynol - pharmacology Phenotype Phosphorylation Precipitin Tests Research facilities Signal Transduction Sphingomyelins - metabolism Time Factors Tretinoin - metabolism Tretinoin - pharmacology
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