Transcriptome Complexity in a Genome-Reduced Bacterium

To study basic principles of transcriptome organization in bacteria, we analyzed one of the smallest self-replicating organisms, Mycoplasma pneumoniae. We combined strand-specific tiling arrays, complemented by transcriptome sequencing, with more than 252 spotted arrays. We detected 117 previously u...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2009-11, Vol.326 (5957), p.1268-1271
Hauptverfasser:	Güell, Marc, van Noort, Vera, Yus, Eva, Chen, Wei-Hua, Leigh-Bell, Justine, Michalodimitrakis, Konstantinos, Yamada, Takuji, Arumugam, Manimozhiyan, Doerks, Tobias, Kühner, Sebastian, Rode, Michaela, Suyama, Mikita, Schmidt, Sabine, Gavin, Anne-Claude, Bork, Peer, Serrano, Luis
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Bacteriology Base Sequence Biological and medical sciences Eukaryotic cells Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Gene Expression Regulation, Bacterial Genes Genes, Bacterial Genetics Genome, Bacterial Genomes Genomics Microbiology Molecular Sequence Data Mycoplasma pneumoniae Mycoplasma pneumoniae - genetics Mycoplasma pneumoniae - metabolism Oligonucleotide Array Sequence Analysis Operon Operons RNA RNA, Antisense - genetics RNA, Antisense - metabolism RNA, Bacterial - genetics RNA, Bacterial - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Untranslated - analysis RNA, Untranslated - genetics Steepest descent method Tiling Transcription, Genetic Transcriptomes
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