Identification of a novel mutations BRCA1c.80 + 3del4 and BRCA2c.6589delA in Slovak HBOC families

Mutations in the BRCA1 and BRCA2 genes account for the majority of hereditary breast ovarian cancer (HBOC) cases. However, after BRCA1 and BRCA2 screening still the most HBOC cases remain negative for any mutational event. Accordingly, in these cases raises the relevance to analyze the unusual BRCA1...

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Veröffentlicht in:	Breast cancer research and treatment 2010, Vol.119 (1), p.233-237
Hauptverfasser:	Konecny, Michal, Vizvaryova, Miriam, Zavodna, Katarina, Behulova, Regina, Gerykova Bujalkova, Maria, Krivulcik, Tomas, Cisarik, Frantisek, Kausitz, Juraj, Weismanova, Eva
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Base Sequence Biological and medical sciences Breast cancer Breast Neoplasms - genetics Brief Report Cancer research DNA Mutational Analysis Exons Family Health Female Female genital diseases Gene Deletion Gene mutations Genes Genes, BRCA1 Genes, BRCA2 Genetic aspects Genetic disorders Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Medicine Medicine & Public Health Middle Aged Molecular Sequence Data Mutation Oncology Ovarian cancer Ovarian Neoplasms - genetics Pedigree Slovakia Tumors
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