An analysis of image texture, tumor location, and MGMT promoter methylation in glioblastoma using magnetic resonance imaging

In glioblastoma (GBM), promoter methylation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) is associated with benefit from chemotherapy. Correlations between MGMT promoter methylation and visually assessed imaging features on magnetic resonance (MR) have been reported suggestin...

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Veröffentlicht in:	NeuroImage (Orlando, Fla.) Fla.), 2010-01, Vol.49 (2), p.1398-1405
Hauptverfasser:	Drabycz, Sylvia, Roldán, Gloria, de Robles, Paula, Adler, Daniel, McIntyre, John B., Magliocco, Anthony M., Cairncross, J. Gregory, Mitchell, J. Ross
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Brain - metabolism Brain - pathology Brain Neoplasms - metabolism Brain Neoplasms - pathology Cancer Classification Cysts Deoxyribonucleic acid DNA DNA Methylation DNA Modification Methylases - genetics DNA Modification Methylases - metabolism DNA Repair Enzymes - genetics DNA Repair Enzymes - metabolism Female Fourier transforms Genetic testing Glioblastoma - metabolism Glioblastoma - pathology Humans Image Processing, Computer-Assisted - methods Magnetic Resonance Imaging - methods Male Medical research Methods Middle Aged Promoter Regions, Genetic Retrospective Studies Software Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumors
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