Biomechanics Bacterial flagellar switching under load
Flagellated bacteria swim up gradients of chemical attractants by modulating the direction of rotation of their flagellar motors, but how this switching mechanism works is not understood. Here we show that the probability of the motor rotating in the clockwise direction increases under high load, wh...
Gespeichert in:
| Veröffentlicht in: | Nature (London) 2003-06, Vol.423 (6943), p.938-938 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 938 |
|---|---|
| container_issue | 6943 |
| container_start_page | 938 |
| container_title | Nature (London) |
| container_volume | 423 |
| creator | Berg, Howard C Fahrner, Karen A Ryu, William S |
| description | Flagellated bacteria swim up gradients of chemical attractants by modulating the direction of rotation of their flagellar motors, but how this switching mechanism works is not understood. Here we show that the probability of the motor rotating in the clockwise direction increases under high load, when the motor spins slowly (at less than 50 Hz). We suggest that either the switch is responding to small changes in torque - the torque increases only fractionally between 50 Hz and stall - or it senses motor speed, perhaps by means of proton flux. |
| doi_str_mv | 10.1038/423938a |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_73417297</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A187719578</galeid><sourcerecordid>A187719578</sourcerecordid><originalsourceid>FETCH-LOGICAL-g366t-903343c8653cf48057e7119bf7e0f458523bcbce0e71ecf97a19e92e1f43aa843</originalsourceid><addsrcrecordid>eNqF0utLwzAQAPAgis4H_gVK8YMg0pk0aZN-nMMXDAUf-LHcskuN9LElLep_b2VTHEwkHw6O312OSwjZZ7TPKFdnIuIpV7BGekzIJBSJkuukR2mkQqp4skW2vX-llMZMik2yxSIVSZbSHonPbV2ifoHKah-cg27QWSgCU0CORQEu8G-20S-2yoO2mqALihomu2TDQOFxbxF3yNPlxePwOhzdXd0MB6Mw50nShCnlXHCtkphrIxSNJUrG0rGRSI2IVRzxsR5rpF0atUklsBTTCJkRHEAJvkOO532nrp616JustF5_zVVh3fpMcsFklMp_IVPdZTFXHQznMIcCM1uZunGgc6zQQVFXaGyXHjAlu_XE8ssfrfB6amfZb9RfgbozwdLqlV1Plgo60-B7k0PrfXbzcL9sT_-2g8fn4e2yPlwsoh2XOMmmzpbgPrLvF-_AwRxU0LQOf8DiB_FPs0KwgA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18852538</pqid></control><display><type>article</type><title>Biomechanics Bacterial flagellar switching under load</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Nature Journals Online</source><creator>Berg, Howard C ; Fahrner, Karen A ; Ryu, William S</creator><creatorcontrib>Berg, Howard C ; Fahrner, Karen A ; Ryu, William S</creatorcontrib><description>Flagellated bacteria swim up gradients of chemical attractants by modulating the direction of rotation of their flagellar motors, but how this switching mechanism works is not understood. Here we show that the probability of the motor rotating in the clockwise direction increases under high load, when the motor spins slowly (at less than 50 Hz). We suggest that either the switch is responding to small changes in torque - the torque increases only fractionally between 50 Hz and stall - or it senses motor speed, perhaps by means of proton flux.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/423938a</identifier><identifier>PMID: 12827190</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Bacterial Proteins ; Biomechanical Phenomena ; Escherichia coli - physiology ; Escherichia coli Proteins - physiology ; Flagella - physiology ; Membrane Proteins - physiology ; Methyl-Accepting Chemotaxis Proteins ; Molecular Motor Proteins - physiology ; Protons ; Torque</subject><ispartof>Nature (London), 2003-06, Vol.423 (6943), p.938-938</ispartof><rights>COPYRIGHT 2003 Nature Publishing Group</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12827190$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berg, Howard C</creatorcontrib><creatorcontrib>Fahrner, Karen A</creatorcontrib><creatorcontrib>Ryu, William S</creatorcontrib><title>Biomechanics Bacterial flagellar switching under load</title><title>Nature (London)</title><addtitle>Nature</addtitle><description>Flagellated bacteria swim up gradients of chemical attractants by modulating the direction of rotation of their flagellar motors, but how this switching mechanism works is not understood. Here we show that the probability of the motor rotating in the clockwise direction increases under high load, when the motor spins slowly (at less than 50 Hz). We suggest that either the switch is responding to small changes in torque - the torque increases only fractionally between 50 Hz and stall - or it senses motor speed, perhaps by means of proton flux.</description><subject>Bacterial Proteins</subject><subject>Biomechanical Phenomena</subject><subject>Escherichia coli - physiology</subject><subject>Escherichia coli Proteins - physiology</subject><subject>Flagella - physiology</subject><subject>Membrane Proteins - physiology</subject><subject>Methyl-Accepting Chemotaxis Proteins</subject><subject>Molecular Motor Proteins - physiology</subject><subject>Protons</subject><subject>Torque</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0utLwzAQAPAgis4H_gVK8YMg0pk0aZN-nMMXDAUf-LHcskuN9LElLep_b2VTHEwkHw6O312OSwjZZ7TPKFdnIuIpV7BGekzIJBSJkuukR2mkQqp4skW2vX-llMZMik2yxSIVSZbSHonPbV2ifoHKah-cg27QWSgCU0CORQEu8G-20S-2yoO2mqALihomu2TDQOFxbxF3yNPlxePwOhzdXd0MB6Mw50nShCnlXHCtkphrIxSNJUrG0rGRSI2IVRzxsR5rpF0atUklsBTTCJkRHEAJvkOO532nrp616JustF5_zVVh3fpMcsFklMp_IVPdZTFXHQznMIcCM1uZunGgc6zQQVFXaGyXHjAlu_XE8ssfrfB6amfZb9RfgbozwdLqlV1Plgo60-B7k0PrfXbzcL9sT_-2g8fn4e2yPlwsoh2XOMmmzpbgPrLvF-_AwRxU0LQOf8DiB_FPs0KwgA</recordid><startdate>20030626</startdate><enddate>20030626</enddate><creator>Berg, Howard C</creator><creator>Fahrner, Karen A</creator><creator>Ryu, William S</creator><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>ATWCN</scope><scope>7QL</scope><scope>7TN</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>20030626</creationdate><title>Biomechanics Bacterial flagellar switching under load</title><author>Berg, Howard C ; Fahrner, Karen A ; Ryu, William S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g366t-903343c8653cf48057e7119bf7e0f458523bcbce0e71ecf97a19e92e1f43aa843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Bacterial Proteins</topic><topic>Biomechanical Phenomena</topic><topic>Escherichia coli - physiology</topic><topic>Escherichia coli Proteins - physiology</topic><topic>Flagella - physiology</topic><topic>Membrane Proteins - physiology</topic><topic>Methyl-Accepting Chemotaxis Proteins</topic><topic>Molecular Motor Proteins - physiology</topic><topic>Protons</topic><topic>Torque</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berg, Howard C</creatorcontrib><creatorcontrib>Fahrner, Karen A</creatorcontrib><creatorcontrib>Ryu, William S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Gale In Context: Middle School</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Oceanic Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berg, Howard C</au><au>Fahrner, Karen A</au><au>Ryu, William S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomechanics Bacterial flagellar switching under load</atitle><jtitle>Nature (London)</jtitle><addtitle>Nature</addtitle><date>2003-06-26</date><risdate>2003</risdate><volume>423</volume><issue>6943</issue><spage>938</spage><epage>938</epage><pages>938-938</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>Flagellated bacteria swim up gradients of chemical attractants by modulating the direction of rotation of their flagellar motors, but how this switching mechanism works is not understood. Here we show that the probability of the motor rotating in the clockwise direction increases under high load, when the motor spins slowly (at less than 50 Hz). We suggest that either the switch is responding to small changes in torque - the torque increases only fractionally between 50 Hz and stall - or it senses motor speed, perhaps by means of proton flux.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>12827190</pmid><doi>10.1038/423938a</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 2003-06, Vol.423 (6943), p.938-938 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73417297 |
| source | MEDLINE; SpringerLink Journals; Nature Journals Online |
| subjects | Bacterial Proteins Biomechanical Phenomena Escherichia coli - physiology Escherichia coli Proteins - physiology Flagella - physiology Membrane Proteins - physiology Methyl-Accepting Chemotaxis Proteins Molecular Motor Proteins - physiology Protons Torque |
| title | Biomechanics Bacterial flagellar switching under load |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T23%3A41%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Biomechanics%20Bacterial%20flagellar%20switching%20under%20load&rft.jtitle=Nature%20(London)&rft.au=Berg,%20Howard%20C&rft.date=2003-06-26&rft.volume=423&rft.issue=6943&rft.spage=938&rft.epage=938&rft.pages=938-938&rft.issn=0028-0836&rft.eissn=1476-4687&rft_id=info:doi/10.1038/423938a&rft_dat=%3Cgale_proqu%3EA187719578%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18852538&rft_id=info:pmid/12827190&rft_galeid=A187719578&rfr_iscdi=true |