Physiologically Based Pharmacokinetic Modeling of Cyclohexane as a Tool for Integrating Animal and Human Test Data

This report describes a physiologically based pharmacokinetic model for cyclohexane and its use in comparing internal doses in rats and volunteers following inhalation exposures. Parameters describing saturable metabolism of cyclohexane are measured in rats and used along with experimentally determi...

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Veröffentlicht in:	International journal of toxicology 2009-11, Vol.28 (6), p.498-509
Hauptverfasser:	Hissink, A. M., Kulig, B. M., Kruse, J., Freidig, A. P., Verwei, M., Muijser, H., Lammers, J. H. C. M., McKee, R. H., Owen, D. E., Sweeney, L. M., Salmon, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Brain - metabolism Cyclohexanes - pharmacokinetics Cyclohexanes - toxicity Data Interpretation, Statistical Humans Male Models, Statistical No-Observed-Adverse-Effect Level Occupational Exposure - adverse effects Occupational Exposure - standards Pharmacokinetics Pulmonary Alveoli - metabolism Rats Rats, Inbred F344 Rats, Wistar Solvents - pharmacokinetics Solvents - toxicity Species Specificity Temperature Tissue Distribution Young Adult
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