Emergence of a new mutation and its accumulation in the topoisomerase IV gene confers high levels of resistance to fluoroquinolones in Escherichia coli isolates

Abstract Mutations in DNA gyrase and topoisomerase IV genes are the main mechanisms of resistance to quinolones. In this study, we determined mutations in gyrA , gyrB , parC and parE among 57 ciprofloxacin-resistant Escherichia coli isolates from a South Korean hospital and analysed the relationship...

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Veröffentlicht in:	International journal of antimicrobial agents 2010-01, Vol.35 (1), p.76-79
Hauptverfasser:	Moon, Dong Chan, Seol, Sung Yong, Gurung, Mamata, Jin, Jong Sook, Choi, Chul Hee, Kim, Jungmin, Lee, Yoo Chul, Cho, Dong Taek, Lee, Je Chul
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution - genetics Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Ciprofloxacin - pharmacology DNA gyrase DNA Gyrase - genetics DNA Topoisomerase IV - genetics Drug Resistance, Bacterial Efflux pump Escherichia coli Escherichia coli - drug effects Escherichia coli Proteins - genetics Fluoroquinolone Fluoroquinolones - pharmacology Humans Infectious Disease Medical sciences Microbial Sensitivity Tests Mutation Mutation, Missense Pharmacology. Drug treatments Point Mutation Republic of Korea Topoisomerase IV
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