Classification of amyloidosis by laser microdissection and mass spectrometry–based proteomic analysis in clinical biopsy specimens

The clinical management of amyloidosis is based on the treatment of the underlying etiology, and accurate identification of the protein causing the amyloidosis is of paramount importance. Current methods used for typing of amyloidosis such as immunohistochemistry have low specificity and sensitivity...

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Veröffentlicht in:	Blood 2009-12, Vol.114 (24), p.4957-4959
Hauptverfasser:	Vrana, Julie A., Gamez, Jeffrey D., Madden, Benjamin J., Theis, Jason D., Bergen Robert, H., Dogan, Ahmet
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloidosis Amyloidosis - classification Biological and medical sciences Female Hematologic and hematopoietic diseases Humans Lasers Male Medical sciences Metabolic diseases Microdissection - methods Other metabolic disorders Proteomics - methods Sensitivity and Specificity Tandem Mass Spectrometry - methods
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