Medication effects on midtrimester maternal serum screening
Objective To determine whether medication classes are associated with alterations in concentrations of Quad screen analytes or the screen-positive rate. Study Design We conducted a retrospective cohort study of women with singleton gestations who received prenatal care and had a Quad screen performe...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2009-12, Vol.201 (6), p.622.e1-622.e5 |
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| container_issue | 6 |
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| container_title | American journal of obstetrics and gynecology |
| container_volume | 201 |
| creator | Pekarek, Dawn M., MD Chapman, Victoria R., BSN, MPH Neely, Cherry L., RDMS Ramsey, Patrick S., MD, MSPH Biggio, Joseph R., MD |
| description | Objective To determine whether medication classes are associated with alterations in concentrations of Quad screen analytes or the screen-positive rate. Study Design We conducted a retrospective cohort study of women with singleton gestations who received prenatal care and had a Quad screen performed in the University of Alabama at Birmingham system. Information on prescription medications was abstracted. Mean multiples of the medians for each analyte (alpha-fetoprotein, estriol, human chorionic gonadotropin, and inhibin A) and overall screening results were compared between those taking the class of medication and controls not taking any medications. Results There were 6206 women evaluated; 1337 took at least 1 prescription medicine and 4869 were controls. Mean analyte multiples of the medians were significantly different in women taking some medications compared with controls. Women taking certain medications had an increased screen-positive rate. Conclusion Medications taken around the time of maternal serum screening are associated with alterations in individual analyte multiples of the medians, as well as the screen-positive rates. |
| doi_str_mv | 10.1016/j.ajog.2009.07.013 |
| format | Article |
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Study Design We conducted a retrospective cohort study of women with singleton gestations who received prenatal care and had a Quad screen performed in the University of Alabama at Birmingham system. Information on prescription medications was abstracted. Mean multiples of the medians for each analyte (alpha-fetoprotein, estriol, human chorionic gonadotropin, and inhibin A) and overall screening results were compared between those taking the class of medication and controls not taking any medications. Results There were 6206 women evaluated; 1337 took at least 1 prescription medicine and 4869 were controls. Mean analyte multiples of the medians were significantly different in women taking some medications compared with controls. Women taking certain medications had an increased screen-positive rate. Conclusion Medications taken around the time of maternal serum screening are associated with alterations in individual analyte multiples of the medians, as well as the screen-positive rates.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2009.07.013</identifier><identifier>PMID: 19762000</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; alpha-Fetoproteins - analysis ; Aneuploidy ; Biological and medical sciences ; Biomarkers - blood ; Chorionic Gonadotropin - blood ; Chromosome Disorders - blood ; Chromosome Disorders - diagnosis ; Cohort Studies ; Estriol - blood ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Inhibins - blood ; Mass Screening ; Maternal serum screening ; Medical sciences ; medications ; Neural Tube Defects - blood ; Neural Tube Defects - diagnosis ; Obstetrics and Gynecology ; Pregnancy ; Pregnancy Trimester, Second ; Prenatal Diagnosis ; Quad screen ; Retrospective Studies ; screen positive ; Young Adult</subject><ispartof>American journal of obstetrics and gynecology, 2009-12, Vol.201 (6), p.622.e1-622.e5</ispartof><rights>Mosby, Inc.</rights><rights>2009 Mosby, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-30505429858926eb8052a6ae689868e9d1780f0af75f24c8aa3315a8a996a8f53</citedby><cites>FETCH-LOGICAL-c440t-30505429858926eb8052a6ae689868e9d1780f0af75f24c8aa3315a8a996a8f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajog.2009.07.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22255725$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19762000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pekarek, Dawn M., MD</creatorcontrib><creatorcontrib>Chapman, Victoria R., BSN, MPH</creatorcontrib><creatorcontrib>Neely, Cherry L., RDMS</creatorcontrib><creatorcontrib>Ramsey, Patrick S., MD, MSPH</creatorcontrib><creatorcontrib>Biggio, Joseph R., MD</creatorcontrib><title>Medication effects on midtrimester maternal serum screening</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective To determine whether medication classes are associated with alterations in concentrations of Quad screen analytes or the screen-positive rate. Study Design We conducted a retrospective cohort study of women with singleton gestations who received prenatal care and had a Quad screen performed in the University of Alabama at Birmingham system. Information on prescription medications was abstracted. Mean multiples of the medians for each analyte (alpha-fetoprotein, estriol, human chorionic gonadotropin, and inhibin A) and overall screening results were compared between those taking the class of medication and controls not taking any medications. Results There were 6206 women evaluated; 1337 took at least 1 prescription medicine and 4869 were controls. Mean analyte multiples of the medians were significantly different in women taking some medications compared with controls. Women taking certain medications had an increased screen-positive rate. Conclusion Medications taken around the time of maternal serum screening are associated with alterations in individual analyte multiples of the medians, as well as the screen-positive rates.</description><subject>Adult</subject><subject>alpha-Fetoproteins - analysis</subject><subject>Aneuploidy</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Chorionic Gonadotropin - blood</subject><subject>Chromosome Disorders - blood</subject><subject>Chromosome Disorders - diagnosis</subject><subject>Cohort Studies</subject><subject>Estriol - blood</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Inhibins - blood</subject><subject>Mass Screening</subject><subject>Maternal serum screening</subject><subject>Medical sciences</subject><subject>medications</subject><subject>Neural Tube Defects - blood</subject><subject>Neural Tube Defects - diagnosis</subject><subject>Obstetrics and Gynecology</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Second</subject><subject>Prenatal Diagnosis</subject><subject>Quad screen</subject><subject>Retrospective Studies</subject><subject>screen positive</subject><subject>Young Adult</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1rFjEUhYNU2re1f8CFzEZczXiTmUwSFEFKP4SKC3UdbjM3JeN81GRG6L83w_tiwUU3-YBzLuc-h7HXHCoOvH3fV9jP95UAMBWoCnj9gu04GFW2utVHbAcAojS10ifsNKV--wojjtkJN6rNNtixD1-pCw6XME8FeU9uSUV-jqFbYhgpLRSLEfM54VAkiutYJBeJpjDdv2IvPQ6Jzg_3Gft5dfnj4qa8_Xb95eLzbemaBpayBgmyEUZLbURLdxqkwBap1SbHJNNxpcEDeiW9aJxGrGsuUaMxLWov6zP2bj_3Ic6_15zJjiE5GgacaF6TVXXDFRcCslLslS7OKUXy9iFvgfHRcrAbM9vbjZndmFlQNjPLpjeH8evdSN2T5QApC94eBJgcDj7i5EL6pxNCSKnElvPjXkcZxp9A0SYXaHKZcMxgbTeH53N8-s_uhjDlcoZf9Eipn9ethGS5TcKC_b7VuZULBkApA_VfQMuddQ</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Pekarek, Dawn M., MD</creator><creator>Chapman, Victoria R., BSN, MPH</creator><creator>Neely, Cherry L., RDMS</creator><creator>Ramsey, Patrick S., MD, MSPH</creator><creator>Biggio, Joseph R., MD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091201</creationdate><title>Medication effects on midtrimester maternal serum screening</title><author>Pekarek, Dawn M., MD ; Chapman, Victoria R., BSN, MPH ; Neely, Cherry L., RDMS ; Ramsey, Patrick S., MD, MSPH ; Biggio, Joseph R., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-30505429858926eb8052a6ae689868e9d1780f0af75f24c8aa3315a8a996a8f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>alpha-Fetoproteins - analysis</topic><topic>Aneuploidy</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Chorionic Gonadotropin - blood</topic><topic>Chromosome Disorders - blood</topic><topic>Chromosome Disorders - diagnosis</topic><topic>Cohort Studies</topic><topic>Estriol - blood</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Inhibins - blood</topic><topic>Mass Screening</topic><topic>Maternal serum screening</topic><topic>Medical sciences</topic><topic>medications</topic><topic>Neural Tube Defects - blood</topic><topic>Neural Tube Defects - diagnosis</topic><topic>Obstetrics and Gynecology</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, Second</topic><topic>Prenatal Diagnosis</topic><topic>Quad screen</topic><topic>Retrospective Studies</topic><topic>screen positive</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pekarek, Dawn M., MD</creatorcontrib><creatorcontrib>Chapman, Victoria R., BSN, MPH</creatorcontrib><creatorcontrib>Neely, Cherry L., RDMS</creatorcontrib><creatorcontrib>Ramsey, Patrick S., MD, MSPH</creatorcontrib><creatorcontrib>Biggio, Joseph R., MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pekarek, Dawn M., MD</au><au>Chapman, Victoria R., BSN, MPH</au><au>Neely, Cherry L., RDMS</au><au>Ramsey, Patrick S., MD, MSPH</au><au>Biggio, Joseph R., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Medication effects on midtrimester maternal serum screening</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>201</volume><issue>6</issue><spage>622.e1</spage><epage>622.e5</epage><pages>622.e1-622.e5</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective To determine whether medication classes are associated with alterations in concentrations of Quad screen analytes or the screen-positive rate. Study Design We conducted a retrospective cohort study of women with singleton gestations who received prenatal care and had a Quad screen performed in the University of Alabama at Birmingham system. Information on prescription medications was abstracted. Mean multiples of the medians for each analyte (alpha-fetoprotein, estriol, human chorionic gonadotropin, and inhibin A) and overall screening results were compared between those taking the class of medication and controls not taking any medications. Results There were 6206 women evaluated; 1337 took at least 1 prescription medicine and 4869 were controls. Mean analyte multiples of the medians were significantly different in women taking some medications compared with controls. Women taking certain medications had an increased screen-positive rate. Conclusion Medications taken around the time of maternal serum screening are associated with alterations in individual analyte multiples of the medians, as well as the screen-positive rates.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>19762000</pmid><doi>10.1016/j.ajog.2009.07.013</doi><tpages>3</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 2009-12, Vol.201 (6), p.622.e1-622.e5 |
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| subjects | Adult alpha-Fetoproteins - analysis Aneuploidy Biological and medical sciences Biomarkers - blood Chorionic Gonadotropin - blood Chromosome Disorders - blood Chromosome Disorders - diagnosis Cohort Studies Estriol - blood Female Gynecology. Andrology. Obstetrics Humans Inhibins - blood Mass Screening Maternal serum screening Medical sciences medications Neural Tube Defects - blood Neural Tube Defects - diagnosis Obstetrics and Gynecology Pregnancy Pregnancy Trimester, Second Prenatal Diagnosis Quad screen Retrospective Studies screen positive Young Adult |
| title | Medication effects on midtrimester maternal serum screening |
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