Natural killer cells in human peripheral blood and primary cutaneous natural killer cell lymphomas may express cutaneous lymphocyte antigen
In normal human peripheral blood, cutaneous lymphocyte antigen is expressed by memory T cells, suggesting a specific tissue-homing population of T cells. In this study it is demonstrated that 6% of CD56 + natural killer cells in peripheral blood also express cutaneous lymphocyte antigen (CLA). It wa...
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| Veröffentlicht in: | Acta dermato-venereologica 2003, Vol.83 (3), p.162-166 |
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| container_title | Acta dermato-venereologica |
| container_volume | 83 |
| creator | CHANGE, Sung-Eun KIM, Mi-Jung LEE, Won-Sin KANG, Yoon-Koo MOON, Kee-Chan KOH, Jai-Kyoung CHOI, Jee-Ho |
| description | In normal human peripheral blood, cutaneous lymphocyte antigen is expressed by memory T cells, suggesting a specific tissue-homing population of T cells. In this study it is demonstrated that 6% of CD56 + natural killer cells in peripheral blood also express cutaneous lymphocyte antigen (CLA). It was also detected that most of the tumor cells in primary cutaneous nasal-type natural killer cell lymphomas were CLA-positive, whereas primary nasal natural killer cell lymphomas were CLA-negative. Although natural killer cells traditionally are known to be non-specific immune cells without antigen specificity and little is known about the role of natural killer cells in skin diseases, the results of this study suggest the existence of a subset of skin-associated CLA+ CD56+ natural killer cells. These natural killer cells may be related to the pathogenesis of primary cutaneous natural killer cell lymphomas. |
| doi_str_mv | 10.1080/00015550310007120 |
| format | Article |
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In this study it is demonstrated that 6% of CD56 + natural killer cells in peripheral blood also express cutaneous lymphocyte antigen (CLA). It was also detected that most of the tumor cells in primary cutaneous nasal-type natural killer cell lymphomas were CLA-positive, whereas primary nasal natural killer cell lymphomas were CLA-negative. Although natural killer cells traditionally are known to be non-specific immune cells without antigen specificity and little is known about the role of natural killer cells in skin diseases, the results of this study suggest the existence of a subset of skin-associated CLA+ CD56+ natural killer cells. These natural killer cells may be related to the pathogenesis of primary cutaneous natural killer cell lymphomas.</description><identifier>ISSN: 0001-5555</identifier><identifier>EISSN: 1651-2057</identifier><identifier>DOI: 10.1080/00015550310007120</identifier><identifier>PMID: 12816147</identifier><identifier>CODEN: ADVEA4</identifier><language>eng</language><publisher>Uppsala: Acta dermato-venereologica</publisher><subject>Adolescent ; Adult ; Aged ; Antigens - immunology ; Biological and medical sciences ; CD56 Antigen - immunology ; Female ; Hematologic and hematopoietic diseases ; Humans ; Killer Cells, Natural - immunology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphocytes - immunology ; Lymphoma, T-Cell, Cutaneous - immunology ; Male ; Medical sciences ; Middle Aged ; Skin - immunology</subject><ispartof>Acta dermato-venereologica, 2003, Vol.83 (3), p.162-166</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-72dd075f54202cbc5f49188cfafe4600b8ec923abe3a7e974a87c33ffb1fd7d43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14792591$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12816147$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHANGE, Sung-Eun</creatorcontrib><creatorcontrib>KIM, Mi-Jung</creatorcontrib><creatorcontrib>LEE, Won-Sin</creatorcontrib><creatorcontrib>KANG, Yoon-Koo</creatorcontrib><creatorcontrib>MOON, Kee-Chan</creatorcontrib><creatorcontrib>KOH, Jai-Kyoung</creatorcontrib><creatorcontrib>CHOI, Jee-Ho</creatorcontrib><title>Natural killer cells in human peripheral blood and primary cutaneous natural killer cell lymphomas may express cutaneous lymphocyte antigen</title><title>Acta dermato-venereologica</title><addtitle>Acta Derm Venereol</addtitle><description>In normal human peripheral blood, cutaneous lymphocyte antigen is expressed by memory T cells, suggesting a specific tissue-homing population of T cells. In this study it is demonstrated that 6% of CD56 + natural killer cells in peripheral blood also express cutaneous lymphocyte antigen (CLA). It was also detected that most of the tumor cells in primary cutaneous nasal-type natural killer cell lymphomas were CLA-positive, whereas primary nasal natural killer cell lymphomas were CLA-negative. Although natural killer cells traditionally are known to be non-specific immune cells without antigen specificity and little is known about the role of natural killer cells in skin diseases, the results of this study suggest the existence of a subset of skin-associated CLA+ CD56+ natural killer cells. These natural killer cells may be related to the pathogenesis of primary cutaneous natural killer cell lymphomas.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antigens - immunology</subject><subject>Biological and medical sciences</subject><subject>CD56 Antigen - immunology</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Killer Cells, Natural - immunology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphocytes - immunology</subject><subject>Lymphoma, T-Cell, Cutaneous - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Skin - immunology</subject><issn>0001-5555</issn><issn>1651-2057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkctOwzAQRS0EoqXwAWyQN7ALeOy4TpYI8ZIq2MA6cpwxDTgP7ESi38BPkyqRitTVzGjOvZoHIefAroEl7IYxBlJKJmDIFHB2QOawlBBxJtUhmW_70QDIGTkJ4XMouYTkmMyAJ7CEWM3J74vueq8d_SqdQ08NOhdoWdN1X-matujLdo1bIHdNU1BdF7T1ZaX9hpq-0zU2faD1vgl1m6pdN5UOtNIbij-txxD-aca-2XQ4mHblB9an5MhqF_Bsigvy_nD_dvcUrV4fn-9uV5ERinWR4kXBlLQy5oyb3Egbp5AkxmqL8ZKxPEGTcqFzFFphqmKdKCOEtTnYQhWxWJCr0bf1zXePocuqMmxnHifLlIhBAcgBhBE0vgnBo82m1TNg2fYD2d4HBs3FZN7nFRY7xXTyAbicAB2Mdtbr2pRhx8Uq5TIF8QfUKZF_</recordid><startdate>2003</startdate><enddate>2003</enddate><creator>CHANGE, Sung-Eun</creator><creator>KIM, Mi-Jung</creator><creator>LEE, Won-Sin</creator><creator>KANG, Yoon-Koo</creator><creator>MOON, Kee-Chan</creator><creator>KOH, Jai-Kyoung</creator><creator>CHOI, Jee-Ho</creator><general>Acta dermato-venereologica</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2003</creationdate><title>Natural killer cells in human peripheral blood and primary cutaneous natural killer cell lymphomas may express cutaneous lymphocyte antigen</title><author>CHANGE, Sung-Eun ; KIM, Mi-Jung ; LEE, Won-Sin ; KANG, Yoon-Koo ; MOON, Kee-Chan ; KOH, Jai-Kyoung ; CHOI, Jee-Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-72dd075f54202cbc5f49188cfafe4600b8ec923abe3a7e974a87c33ffb1fd7d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antigens - immunology</topic><topic>Biological and medical sciences</topic><topic>CD56 Antigen - immunology</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Killer Cells, Natural - immunology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphocytes - immunology</topic><topic>Lymphoma, T-Cell, Cutaneous - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Skin - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHANGE, Sung-Eun</creatorcontrib><creatorcontrib>KIM, Mi-Jung</creatorcontrib><creatorcontrib>LEE, Won-Sin</creatorcontrib><creatorcontrib>KANG, Yoon-Koo</creatorcontrib><creatorcontrib>MOON, Kee-Chan</creatorcontrib><creatorcontrib>KOH, Jai-Kyoung</creatorcontrib><creatorcontrib>CHOI, Jee-Ho</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta dermato-venereologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHANGE, Sung-Eun</au><au>KIM, Mi-Jung</au><au>LEE, Won-Sin</au><au>KANG, Yoon-Koo</au><au>MOON, Kee-Chan</au><au>KOH, Jai-Kyoung</au><au>CHOI, Jee-Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural killer cells in human peripheral blood and primary cutaneous natural killer cell lymphomas may express cutaneous lymphocyte antigen</atitle><jtitle>Acta dermato-venereologica</jtitle><addtitle>Acta Derm Venereol</addtitle><date>2003</date><risdate>2003</risdate><volume>83</volume><issue>3</issue><spage>162</spage><epage>166</epage><pages>162-166</pages><issn>0001-5555</issn><eissn>1651-2057</eissn><coden>ADVEA4</coden><abstract>In normal human peripheral blood, cutaneous lymphocyte antigen is expressed by memory T cells, suggesting a specific tissue-homing population of T cells. 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| ispartof | Acta dermato-venereologica, 2003, Vol.83 (3), p.162-166 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Antigens - immunology Biological and medical sciences CD56 Antigen - immunology Female Hematologic and hematopoietic diseases Humans Killer Cells, Natural - immunology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocytes - immunology Lymphoma, T-Cell, Cutaneous - immunology Male Medical sciences Middle Aged Skin - immunology |
| title | Natural killer cells in human peripheral blood and primary cutaneous natural killer cell lymphomas may express cutaneous lymphocyte antigen |
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