Deoxyribonucleic acid ploidy in endometrial carcinoma: a reproducible and valid prognostic marker in a routine diagnostic setting
Objective The objective of the study was to investigate the prognostic impact of deoxyribonucleic acid (DNA) ploidy in endometrial carcinoma in a routine diagnostic series as compared with a research series. Study Design We studied a population-based series of 363 endometrial carcinomas prospectivel...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2009-12, Vol.201 (6), p.603.e1-603.e7 |
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| creator | Wik, Elisabeth, MD Trovik, Jone, MD Iversen, Ole E., MD, PhD Engelsen, Ingeborg B., MD, PhD Stefansson, Ingunn M., MD, PhD Vestrheim, Liv C., MD Haugland, Hans K., MD, PhD Akslen, Lars A., MD, PhD Salvesen, Helga B., MD, PhD |
| description | Objective The objective of the study was to investigate the prognostic impact of deoxyribonucleic acid (DNA) ploidy in endometrial carcinoma in a routine diagnostic series as compared with a research series. Study Design We studied a population-based series of 363 endometrial carcinomas prospectively collected, with long and complete follow-up. The prognostic value of DNA ploidy was investigated in a routine diagnostic series (n = 262) and compared with the results from a previous research series (n = 101). Results The proportion of DNA aneuploid tumors was 21% in the research series and 25% in the routine diagnostic series ( P = NS). In both series, DNA aneuploidy was significantly correlated to higher age at diagnosis, nonendometrioid subtype, and high histologic grade. Patients with DNA aneuploid tumors had significantly poorer survival, adjusted for established clinicopathologic prognostic factors. Conclusion DNA ploidy estimation in endometrial carcinoma adds independent prognostic information in a routine diagnostic setting. |
| doi_str_mv | 10.1016/j.ajog.2009.07.029 |
| format | Article |
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Study Design We studied a population-based series of 363 endometrial carcinomas prospectively collected, with long and complete follow-up. The prognostic value of DNA ploidy was investigated in a routine diagnostic series (n = 262) and compared with the results from a previous research series (n = 101). Results The proportion of DNA aneuploid tumors was 21% in the research series and 25% in the routine diagnostic series ( P = NS). In both series, DNA aneuploidy was significantly correlated to higher age at diagnosis, nonendometrioid subtype, and high histologic grade. Patients with DNA aneuploid tumors had significantly poorer survival, adjusted for established clinicopathologic prognostic factors. Conclusion DNA ploidy estimation in endometrial carcinoma adds independent prognostic information in a routine diagnostic setting.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2009.07.029</identifier><identifier>PMID: 19800606</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Aged ; Aneuploidy ; Biological and medical sciences ; Biomarkers, Tumor - genetics ; deoxyribonucleic acid ploidy ; DNA - genetics ; endometrial carcinoma ; Endometrial Neoplasms - genetics ; Female ; Female genital diseases ; Follow-Up Studies ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Middle Aged ; Obstetrics and Gynecology ; Ploidies ; Prognosis ; prognostic marker ; Prospective Studies ; Reproducibility of Results ; survival ; Tumors ; validation study</subject><ispartof>American journal of obstetrics and gynecology, 2009-12, Vol.201 (6), p.603.e1-603.e7</ispartof><rights>Mosby, Inc.</rights><rights>2009 Mosby, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-bbd33ccf05171dd9447b07241ddbb598010d95a95a6df0d2213b5f4c900a767a3</citedby><cites>FETCH-LOGICAL-c440t-bbd33ccf05171dd9447b07241ddbb598010d95a95a6df0d2213b5f4c900a767a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajog.2009.07.029$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22255717$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19800606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wik, Elisabeth, MD</creatorcontrib><creatorcontrib>Trovik, Jone, MD</creatorcontrib><creatorcontrib>Iversen, Ole E., MD, PhD</creatorcontrib><creatorcontrib>Engelsen, Ingeborg B., MD, PhD</creatorcontrib><creatorcontrib>Stefansson, Ingunn M., MD, PhD</creatorcontrib><creatorcontrib>Vestrheim, Liv C., MD</creatorcontrib><creatorcontrib>Haugland, Hans K., MD, PhD</creatorcontrib><creatorcontrib>Akslen, Lars A., MD, PhD</creatorcontrib><creatorcontrib>Salvesen, Helga B., MD, PhD</creatorcontrib><title>Deoxyribonucleic acid ploidy in endometrial carcinoma: a reproducible and valid prognostic marker in a routine diagnostic setting</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective The objective of the study was to investigate the prognostic impact of deoxyribonucleic acid (DNA) ploidy in endometrial carcinoma in a routine diagnostic series as compared with a research series. Study Design We studied a population-based series of 363 endometrial carcinomas prospectively collected, with long and complete follow-up. The prognostic value of DNA ploidy was investigated in a routine diagnostic series (n = 262) and compared with the results from a previous research series (n = 101). Results The proportion of DNA aneuploid tumors was 21% in the research series and 25% in the routine diagnostic series ( P = NS). In both series, DNA aneuploidy was significantly correlated to higher age at diagnosis, nonendometrioid subtype, and high histologic grade. Patients with DNA aneuploid tumors had significantly poorer survival, adjusted for established clinicopathologic prognostic factors. Conclusion DNA ploidy estimation in endometrial carcinoma adds independent prognostic information in a routine diagnostic setting.</description><subject>Aged</subject><subject>Aneuploidy</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - genetics</subject><subject>deoxyribonucleic acid ploidy</subject><subject>DNA - genetics</subject><subject>endometrial carcinoma</subject><subject>Endometrial Neoplasms - genetics</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Follow-Up Studies</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Obstetrics and Gynecology</subject><subject>Ploidies</subject><subject>Prognosis</subject><subject>prognostic marker</subject><subject>Prospective Studies</subject><subject>Reproducibility of Results</subject><subject>survival</subject><subject>Tumors</subject><subject>validation study</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kkuLFDEUhYMoTjv6B1xINuKqypvUI1UiAzI-YcCFug6p5FaTmlTSJlWDvfSfm6JbBRdCIK9zTu79CCFPGZQMWPtyKtUU9iUH6EsQJfD-Htkx6EXRdm13n-wAgBd9JboL8iiladvynj8kF6zvAFpod-TnWww_jtEOwa_aodVUaWvowQVrjtR6it6EGZdolaNaRW19mNUrqmjEQwxm1XZwSJU39E65zRnD3oe05KRZxVuMW0hWh3WxHqmx6vd1wiUf7R-TB6NyCZ-c50vy7f27r9cfi5vPHz5dv7kpdF3DUgyDqSqtR2iYYMb0dS0GELzO62Focj8MTN-oPFozguGcVUMz1roHUKIVqrokL065ucLvK6ZFzjZpdE55DGuSoqpzMrAqK_lJqWNIKeIoD9HmZo6SgdzIy0lu5OVGXoKQmXw2PTvHr8OM5q_ljDoLnp8FKmnlxqi8tumPjnPeNIKJrHt90mGGcWcxyqQteo3GRtSLNMH-v46rf-zaWW_zi7d4xDSFNfqMWTKZuAT5ZfsU2xeBDKpjbVX9Aq-nuMQ</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Wik, Elisabeth, MD</creator><creator>Trovik, Jone, MD</creator><creator>Iversen, Ole E., MD, PhD</creator><creator>Engelsen, Ingeborg B., MD, PhD</creator><creator>Stefansson, Ingunn M., MD, PhD</creator><creator>Vestrheim, Liv C., MD</creator><creator>Haugland, Hans K., MD, PhD</creator><creator>Akslen, Lars A., MD, PhD</creator><creator>Salvesen, Helga B., MD, PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091201</creationdate><title>Deoxyribonucleic acid ploidy in endometrial carcinoma: a reproducible and valid prognostic marker in a routine diagnostic setting</title><author>Wik, Elisabeth, MD ; Trovik, Jone, MD ; Iversen, Ole E., MD, PhD ; Engelsen, Ingeborg B., MD, PhD ; Stefansson, Ingunn M., MD, PhD ; Vestrheim, Liv C., MD ; Haugland, Hans K., MD, PhD ; Akslen, Lars A., MD, PhD ; Salvesen, Helga B., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-bbd33ccf05171dd9447b07241ddbb598010d95a95a6df0d2213b5f4c900a767a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Aneuploidy</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - genetics</topic><topic>deoxyribonucleic acid ploidy</topic><topic>DNA - genetics</topic><topic>endometrial carcinoma</topic><topic>Endometrial Neoplasms - genetics</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Follow-Up Studies</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Obstetrics and Gynecology</topic><topic>Ploidies</topic><topic>Prognosis</topic><topic>prognostic marker</topic><topic>Prospective Studies</topic><topic>Reproducibility of Results</topic><topic>survival</topic><topic>Tumors</topic><topic>validation study</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wik, Elisabeth, MD</creatorcontrib><creatorcontrib>Trovik, Jone, MD</creatorcontrib><creatorcontrib>Iversen, Ole E., MD, PhD</creatorcontrib><creatorcontrib>Engelsen, Ingeborg B., MD, PhD</creatorcontrib><creatorcontrib>Stefansson, Ingunn M., MD, PhD</creatorcontrib><creatorcontrib>Vestrheim, Liv C., MD</creatorcontrib><creatorcontrib>Haugland, Hans K., MD, PhD</creatorcontrib><creatorcontrib>Akslen, Lars A., MD, PhD</creatorcontrib><creatorcontrib>Salvesen, Helga B., MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wik, Elisabeth, MD</au><au>Trovik, Jone, MD</au><au>Iversen, Ole E., MD, PhD</au><au>Engelsen, Ingeborg B., MD, PhD</au><au>Stefansson, Ingunn M., MD, PhD</au><au>Vestrheim, Liv C., MD</au><au>Haugland, Hans K., MD, PhD</au><au>Akslen, Lars A., MD, PhD</au><au>Salvesen, Helga B., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deoxyribonucleic acid ploidy in endometrial carcinoma: a reproducible and valid prognostic marker in a routine diagnostic setting</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>201</volume><issue>6</issue><spage>603.e1</spage><epage>603.e7</epage><pages>603.e1-603.e7</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective The objective of the study was to investigate the prognostic impact of deoxyribonucleic acid (DNA) ploidy in endometrial carcinoma in a routine diagnostic series as compared with a research series. Study Design We studied a population-based series of 363 endometrial carcinomas prospectively collected, with long and complete follow-up. The prognostic value of DNA ploidy was investigated in a routine diagnostic series (n = 262) and compared with the results from a previous research series (n = 101). Results The proportion of DNA aneuploid tumors was 21% in the research series and 25% in the routine diagnostic series ( P = NS). In both series, DNA aneuploidy was significantly correlated to higher age at diagnosis, nonendometrioid subtype, and high histologic grade. Patients with DNA aneuploid tumors had significantly poorer survival, adjusted for established clinicopathologic prognostic factors. Conclusion DNA ploidy estimation in endometrial carcinoma adds independent prognostic information in a routine diagnostic setting.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>19800606</pmid><doi>10.1016/j.ajog.2009.07.029</doi><tpages>3</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 2009-12, Vol.201 (6), p.603.e1-603.e7 |
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| subjects | Aged Aneuploidy Biological and medical sciences Biomarkers, Tumor - genetics deoxyribonucleic acid ploidy DNA - genetics endometrial carcinoma Endometrial Neoplasms - genetics Female Female genital diseases Follow-Up Studies Gynecology. Andrology. Obstetrics Humans Medical sciences Middle Aged Obstetrics and Gynecology Ploidies Prognosis prognostic marker Prospective Studies Reproducibility of Results survival Tumors validation study |
| title | Deoxyribonucleic acid ploidy in endometrial carcinoma: a reproducible and valid prognostic marker in a routine diagnostic setting |
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