Laparoscopically assisted uterine fibroid cryoablation
Objective The objective of the study was to develop a safe and effective cryoablation technique for the treatment of uterine fibroids. Study Design This was a multicenter pilot case series to evaluate cryoablation of uterine fibroids using laparoscopically assisted placement of 17-gauge cryoablation...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2009-12, Vol.201 (6), p.571.e1-571.e7 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Pansky, Moty, MD Cowan, Bryan D., MD Frank, Maya, MD Hampton, Harriette L., MD Zimberg, Stephen, MD |
| description | Objective The objective of the study was to develop a safe and effective cryoablation technique for the treatment of uterine fibroids. Study Design This was a multicenter pilot case series to evaluate cryoablation of uterine fibroids using laparoscopically assisted placement of 17-gauge cryoablation needles. Patient satisfaction was documented with a validated Uterine Fibroid Symptom and Quality of Life (UFS-QOL) questionnaire. Procedural efficacy was evaluated by assessing fibroid shrinkage. Treatment was followed by assessments at 3, 6, and 12 months. Results Median fibroid volume reduction was 43.3% (19 patients) and 66.4% (15 patients) at 6 and 12 months, respectively. Median UFS-QOL score improvement was 61.9% and 66.7% at 6 and 12 months, respectively. Additionally, patients experienced marked improvement of bleeding and fibroid bulk symptoms. The median Symptom Severity Score at baseline was 50, 25.0 (–59%) at 6 months, and 12.5 (–66.7%) at 12 months. Conclusion These pilot data indicate that uterine fibroid cryoablation is a safe and effective minimally invasive alternative to treat symptomatic uterine fibroids. |
| doi_str_mv | 10.1016/j.ajog.2009.06.028 |
| format | Article |
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Study Design This was a multicenter pilot case series to evaluate cryoablation of uterine fibroids using laparoscopically assisted placement of 17-gauge cryoablation needles. Patient satisfaction was documented with a validated Uterine Fibroid Symptom and Quality of Life (UFS-QOL) questionnaire. Procedural efficacy was evaluated by assessing fibroid shrinkage. Treatment was followed by assessments at 3, 6, and 12 months. Results Median fibroid volume reduction was 43.3% (19 patients) and 66.4% (15 patients) at 6 and 12 months, respectively. Median UFS-QOL score improvement was 61.9% and 66.7% at 6 and 12 months, respectively. Additionally, patients experienced marked improvement of bleeding and fibroid bulk symptoms. The median Symptom Severity Score at baseline was 50, 25.0 (–59%) at 6 months, and 12.5 (–66.7%) at 12 months. Conclusion These pilot data indicate that uterine fibroid cryoablation is a safe and effective minimally invasive alternative to treat symptomatic uterine fibroids.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2009.06.028</identifier><identifier>PMID: 19716538</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Biological and medical sciences ; cryo ; cryoablation ; Cryosurgery - instrumentation ; cryotherapy ; Digestive system. Abdomen ; Endoscopy ; Female ; Female genital diseases ; fibroid ; Gynecology. Andrology. Obstetrics ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Laparoscopy ; leiomyoma ; Leiomyoma - surgery ; Medical sciences ; Middle Aged ; Needles ; Obstetrics and Gynecology ; Pilot Projects ; Prospective Studies ; quality of life ; Treatment Outcome ; Tumors ; Uterine Neoplasms - surgery</subject><ispartof>American journal of obstetrics and gynecology, 2009-12, Vol.201 (6), p.571.e1-571.e7</ispartof><rights>Mosby, Inc.</rights><rights>2009 Mosby, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-edf702f75c4b841edd7c0d3332f08faed50b0ddec531cff6ebfac612d5ab97593</citedby><cites>FETCH-LOGICAL-c440t-edf702f75c4b841edd7c0d3332f08faed50b0ddec531cff6ebfac612d5ab97593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajog.2009.06.028$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22255705$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19716538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pansky, Moty, MD</creatorcontrib><creatorcontrib>Cowan, Bryan D., MD</creatorcontrib><creatorcontrib>Frank, Maya, MD</creatorcontrib><creatorcontrib>Hampton, Harriette L., MD</creatorcontrib><creatorcontrib>Zimberg, Stephen, MD</creatorcontrib><title>Laparoscopically assisted uterine fibroid cryoablation</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective The objective of the study was to develop a safe and effective cryoablation technique for the treatment of uterine fibroids. Study Design This was a multicenter pilot case series to evaluate cryoablation of uterine fibroids using laparoscopically assisted placement of 17-gauge cryoablation needles. Patient satisfaction was documented with a validated Uterine Fibroid Symptom and Quality of Life (UFS-QOL) questionnaire. Procedural efficacy was evaluated by assessing fibroid shrinkage. Treatment was followed by assessments at 3, 6, and 12 months. Results Median fibroid volume reduction was 43.3% (19 patients) and 66.4% (15 patients) at 6 and 12 months, respectively. Median UFS-QOL score improvement was 61.9% and 66.7% at 6 and 12 months, respectively. Additionally, patients experienced marked improvement of bleeding and fibroid bulk symptoms. The median Symptom Severity Score at baseline was 50, 25.0 (–59%) at 6 months, and 12.5 (–66.7%) at 12 months. Conclusion These pilot data indicate that uterine fibroid cryoablation is a safe and effective minimally invasive alternative to treat symptomatic uterine fibroids.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>cryo</subject><subject>cryoablation</subject><subject>Cryosurgery - instrumentation</subject><subject>cryotherapy</subject><subject>Digestive system. Abdomen</subject><subject>Endoscopy</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>fibroid</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Laparoscopy</subject><subject>leiomyoma</subject><subject>Leiomyoma - surgery</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Needles</subject><subject>Obstetrics and Gynecology</subject><subject>Pilot Projects</subject><subject>Prospective Studies</subject><subject>quality of life</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Uterine Neoplasms - surgery</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1q3DAURkVJaaZpXyCLMpvQld0ryZJsKIEQ-gcDXTRZC1m6CnI91lSyC_P2lZmhhSy6EoLzXemej5BrCjUFKj8MtRniU80AuhpkDax9QTYUOlXJVrYXZAMArOq4ai_J65yH9co69opc0k5RKXi7IXJnDibFbOMhWDOOx63JOeQZ3XaZMYUJtz70KQa3tekYTT-aOcTpDXnpzZjx7fm8Io-fPz3cf6123798u7_bVbZpYK7QeQXMK2Gbvm0oOqcsOM4589B6g05AD86hFZxa7yX23lhJmROm75To-BV5f5p7SPHXgnnW-5AtjqOZMC5ZK95QBYKKQrITacs2OaHXhxT2Jh01Bb3q0oNedelVlwapi64Sencev_R7dP8iZz8FuDkDJhc9PpnJhvyXY4wJUd4v3McTh0XG74BJZxtwsuhCQjtrF8P__3H7LG7HMK2F_MQj5iEuaSqaNdWZadA_1ibXXqEDkIpx_ge42p6U</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Pansky, Moty, MD</creator><creator>Cowan, Bryan D., MD</creator><creator>Frank, Maya, MD</creator><creator>Hampton, Harriette L., MD</creator><creator>Zimberg, Stephen, MD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091201</creationdate><title>Laparoscopically assisted uterine fibroid cryoablation</title><author>Pansky, Moty, MD ; Cowan, Bryan D., MD ; Frank, Maya, MD ; Hampton, Harriette L., MD ; Zimberg, Stephen, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-edf702f75c4b841edd7c0d3332f08faed50b0ddec531cff6ebfac612d5ab97593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>cryo</topic><topic>cryoablation</topic><topic>Cryosurgery - instrumentation</topic><topic>cryotherapy</topic><topic>Digestive system. Abdomen</topic><topic>Endoscopy</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>fibroid</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Laparoscopy</topic><topic>leiomyoma</topic><topic>Leiomyoma - surgery</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Needles</topic><topic>Obstetrics and Gynecology</topic><topic>Pilot Projects</topic><topic>Prospective Studies</topic><topic>quality of life</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Uterine Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pansky, Moty, MD</creatorcontrib><creatorcontrib>Cowan, Bryan D., MD</creatorcontrib><creatorcontrib>Frank, Maya, MD</creatorcontrib><creatorcontrib>Hampton, Harriette L., MD</creatorcontrib><creatorcontrib>Zimberg, Stephen, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pansky, Moty, MD</au><au>Cowan, Bryan D., MD</au><au>Frank, Maya, MD</au><au>Hampton, Harriette L., MD</au><au>Zimberg, Stephen, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Laparoscopically assisted uterine fibroid cryoablation</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>201</volume><issue>6</issue><spage>571.e1</spage><epage>571.e7</epage><pages>571.e1-571.e7</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective The objective of the study was to develop a safe and effective cryoablation technique for the treatment of uterine fibroids. Study Design This was a multicenter pilot case series to evaluate cryoablation of uterine fibroids using laparoscopically assisted placement of 17-gauge cryoablation needles. Patient satisfaction was documented with a validated Uterine Fibroid Symptom and Quality of Life (UFS-QOL) questionnaire. Procedural efficacy was evaluated by assessing fibroid shrinkage. Treatment was followed by assessments at 3, 6, and 12 months. Results Median fibroid volume reduction was 43.3% (19 patients) and 66.4% (15 patients) at 6 and 12 months, respectively. Median UFS-QOL score improvement was 61.9% and 66.7% at 6 and 12 months, respectively. Additionally, patients experienced marked improvement of bleeding and fibroid bulk symptoms. The median Symptom Severity Score at baseline was 50, 25.0 (–59%) at 6 months, and 12.5 (–66.7%) at 12 months. Conclusion These pilot data indicate that uterine fibroid cryoablation is a safe and effective minimally invasive alternative to treat symptomatic uterine fibroids.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>19716538</pmid><doi>10.1016/j.ajog.2009.06.028</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Biological and medical sciences cryo cryoablation Cryosurgery - instrumentation cryotherapy Digestive system. Abdomen Endoscopy Female Female genital diseases fibroid Gynecology. Andrology. Obstetrics Humans Investigative techniques, diagnostic techniques (general aspects) Laparoscopy leiomyoma Leiomyoma - surgery Medical sciences Middle Aged Needles Obstetrics and Gynecology Pilot Projects Prospective Studies quality of life Treatment Outcome Tumors Uterine Neoplasms - surgery |
| title | Laparoscopically assisted uterine fibroid cryoablation |
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