Extramammary Paget’s disease with intracytoplasmic lumen formation
Extramammary Paget’s disease (EMPD) is regarded as a malignancy most likely derived from or differentiated into apocrine sweat duct and gland. The tumor cells in EMPD usually have abundant pale cytoplasm and large pleomorphic nuclei. We present a case with EMPD where the tumor included many signet r...
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| Veröffentlicht in: | Journal of dermatology 2009-12, Vol.36 (12), p.649-653 |
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| container_issue | 12 |
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| container_title | Journal of dermatology |
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| creator | TSUNEMI, Yuichiro SAEKI, Hidehisa KIKUCHI, Kanako TAMAKI, Kunihiko SATO, Shinichi |
| description | Extramammary Paget’s disease (EMPD) is regarded as a malignancy most likely derived from or differentiated into apocrine sweat duct and gland. The tumor cells in EMPD usually have abundant pale cytoplasm and large pleomorphic nuclei. We present a case with EMPD where the tumor included many signet ring cells, cells with intracytoplasmic lumen formation and glandular formation. This case is interesting in that the tumor included many cells with intracytoplasmic lumen formation. Signet ring cells and glandular formation support the traditional speculation that EMPD is derived from apocrine sweat gland and intracytoplasmic lumen formation may mimic the intrafollicular apocrine duct. |
| doi_str_mv | 10.1111/j.1346-8138.2009.00725.x |
| format | Article |
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The tumor cells in EMPD usually have abundant pale cytoplasm and large pleomorphic nuclei. We present a case with EMPD where the tumor included many signet ring cells, cells with intracytoplasmic lumen formation and glandular formation. This case is interesting in that the tumor included many cells with intracytoplasmic lumen formation. 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The tumor cells in EMPD usually have abundant pale cytoplasm and large pleomorphic nuclei. We present a case with EMPD where the tumor included many signet ring cells, cells with intracytoplasmic lumen formation and glandular formation. This case is interesting in that the tumor included many cells with intracytoplasmic lumen formation. Signet ring cells and glandular formation support the traditional speculation that EMPD is derived from apocrine sweat gland and intracytoplasmic lumen formation may mimic the intrafollicular apocrine duct.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>apocrine</subject><subject>Carcinoma, Signet Ring Cell - diagnosis</subject><subject>Cytoplasm - pathology</subject><subject>Diagnosis, Differential</subject><subject>extramammary Paget’s disease</subject><subject>Genital Neoplasms, Male - diagnosis</subject><subject>Genital Neoplasms, Male - pathology</subject><subject>glandular</subject><subject>Humans</subject><subject>intracytoplasmic</subject><subject>lumen</subject><subject>Male</subject><subject>Paget Disease, Extramammary - diagnosis</subject><subject>Paget Disease, Extramammary - pathology</subject><subject>signet ring cell</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - pathology</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtOwzAQQC0EoqVwBZQdq4TxL7ElNqgtP1WCBawtx3HAVT4lTtR2xzW4HichoRVsmc2MNG9mNA-hAEOE-7hcRpiyOBSYiogAyAggITzaHKDxb-MQjYEKHhIGyQideL8EIJJjOEYjLCUXjMMYzeabttGlLkvdbIMn_Wrbr49PH2TOW-1tsHbtW-CqnjHbtl4V2pfOBEVX2irI66bUraurU3SU68Lbs32eoJeb-fP0Llw83t5PrxehYQR42N-OiU0ozjVnSYJNHgMIZo3JgHCZWUpYLjMRk1QSLjRY0CLjNJU5ljhldIIudntXTf3eWd-q0nlji0JXtu68SijDCdCE9KTYkaapvW9srlaNG15UGNSgUC3VYEoNptSgUP0oVJt-9Hx_pEtLm_0N7p31wNUOWLvCbv-9WD3M5n1BvwH7xIAF</recordid><startdate>200912</startdate><enddate>200912</enddate><creator>TSUNEMI, Yuichiro</creator><creator>SAEKI, Hidehisa</creator><creator>KIKUCHI, Kanako</creator><creator>TAMAKI, Kunihiko</creator><creator>SATO, Shinichi</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200912</creationdate><title>Extramammary Paget’s disease with intracytoplasmic lumen formation</title><author>TSUNEMI, Yuichiro ; SAEKI, Hidehisa ; KIKUCHI, Kanako ; TAMAKI, Kunihiko ; SATO, Shinichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4205-51062e731fa54771cf60084eccd0259de324f9d862b9258a0e0a8d53b9f191b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>apocrine</topic><topic>Carcinoma, Signet Ring Cell - diagnosis</topic><topic>Cytoplasm - pathology</topic><topic>Diagnosis, Differential</topic><topic>extramammary Paget’s disease</topic><topic>Genital Neoplasms, Male - diagnosis</topic><topic>Genital Neoplasms, Male - pathology</topic><topic>glandular</topic><topic>Humans</topic><topic>intracytoplasmic</topic><topic>lumen</topic><topic>Male</topic><topic>Paget Disease, Extramammary - diagnosis</topic><topic>Paget Disease, Extramammary - pathology</topic><topic>signet ring cell</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Skin Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TSUNEMI, Yuichiro</creatorcontrib><creatorcontrib>SAEKI, Hidehisa</creatorcontrib><creatorcontrib>KIKUCHI, Kanako</creatorcontrib><creatorcontrib>TAMAKI, Kunihiko</creatorcontrib><creatorcontrib>SATO, Shinichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TSUNEMI, Yuichiro</au><au>SAEKI, Hidehisa</au><au>KIKUCHI, Kanako</au><au>TAMAKI, Kunihiko</au><au>SATO, Shinichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extramammary Paget’s disease with intracytoplasmic lumen formation</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2009-12</date><risdate>2009</risdate><volume>36</volume><issue>12</issue><spage>649</spage><epage>653</epage><pages>649-653</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>Extramammary Paget’s disease (EMPD) is regarded as a malignancy most likely derived from or differentiated into apocrine sweat duct and gland. The tumor cells in EMPD usually have abundant pale cytoplasm and large pleomorphic nuclei. We present a case with EMPD where the tumor included many signet ring cells, cells with intracytoplasmic lumen formation and glandular formation. This case is interesting in that the tumor included many cells with intracytoplasmic lumen formation. Signet ring cells and glandular formation support the traditional speculation that EMPD is derived from apocrine sweat gland and intracytoplasmic lumen formation may mimic the intrafollicular apocrine duct.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19958450</pmid><doi>10.1111/j.1346-8138.2009.00725.x</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of dermatology, 2009-12, Vol.36 (12), p.649-653 |
| issn | 0385-2407 1346-8138 |
| language | eng |
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| subjects | Aged Aged, 80 and over apocrine Carcinoma, Signet Ring Cell - diagnosis Cytoplasm - pathology Diagnosis, Differential extramammary Paget’s disease Genital Neoplasms, Male - diagnosis Genital Neoplasms, Male - pathology glandular Humans intracytoplasmic lumen Male Paget Disease, Extramammary - diagnosis Paget Disease, Extramammary - pathology signet ring cell Skin Neoplasms - diagnosis Skin Neoplasms - pathology |
| title | Extramammary Paget’s disease with intracytoplasmic lumen formation |
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