Ocular hypertension impairs optic nerve axonal transport leading to progressive retinal ganglion cell degeneration

Ocular hypertension (OHT) is the main risk factor of glaucoma, a neuropathy leading to blindness. Here we have investigated the effects of laser photocoagulation (LP)-induced OHT, on the survival and retrograde axonal transport (RAT) of adult rat retinal ganglion cells (RGC) from 1 to 12 wks. Active...

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Veröffentlicht in:	Experimental eye research 2010, Vol.90 (1), p.168-183
Hauptverfasser:	Salinas-Navarro, Manuel, Alarcón-Martínez, Luis, Valiente-Soriano, Francisco J., Jiménez-López, Manuel, Mayor-Torroglosa, Sergio, Avilés-Trigueros, Marcelino, Villegas-Pérez, María Paz, Vidal-Sanz, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	adult albino rat retinal ganglion cells Animals Axonal Transport Axons Blindness Brn-3 protein Brn3a Cell Count Cell survival Degeneration Dextran dextran tetramethylrhodamine Dextrans - metabolism Diffusion Disease Models, Animal Disease Progression Eye Female Fibers fluorescent tracers fluorogold Glaucoma Head Hypertension Injuries Intraocular Pressure Laser Coagulation Lasers neuronal degeneration Neuropathy ocular hypertension Ocular Hypertension - complications Optic nerve Optic Nerve Diseases - etiology Optic Nerve Diseases - metabolism Optic Nerve Diseases - pathology phosphorilated neurofilament heavy chain Rats Rats, Sprague-Dawley Retina Retinal Degeneration - etiology Retinal Degeneration - metabolism Retinal Degeneration - pathology Retinal ganglion cells Retinal Ganglion Cells - pathology retrograde axonal transport Rhodamines - metabolism RT97 Stilbamidines - metabolism Tonometry, Ocular
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