Does a Nanomolecule of Carboplatin Injected Periocularly Help in Attaining Higher Intravitreal Concentrations?

To compare intravitreal concentration (VC) of commercially available carboplatin (CAC) and the novel nanomolecule carboplatin (NMC), after periocular injection. The study was a comparative animal study involving 24 white Sprague-Dawley rats, aged between 6 weeks and 3 months. CAC was bound with a na...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2009-12, Vol.50 (12), p.5896-5900
Hauptverfasser:	Shome, Debraj, Poddar, Neha, Sharma, Vinay, Sheorey, Uday, Maru, Girish B, Ingle, Arvind, Sarin, Rajiv, Banavali, Shripad, Dikshit, Rajesh, Jain, Vandana, Honavar, Santosh, Bellare, Jayesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Availability Carboplatin - chemistry Carboplatin - pharmacokinetics Chromatography, High Pressure Liquid Drug Carriers Electrophoresis, Polyacrylamide Gel Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Injections Medical sciences Microscopy, Electron, Transmission Nanocapsules - chemistry Nanocapsules - ultrastructure Ophthalmology Rats Rats, Sprague-Dawley Serum Albumin, Bovine - chemistry Spectroscopy, Fourier Transform Infrared Tissue Distribution Vertebrates: nervous system and sense organs Vitreous Body - metabolism
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