Imidazoquines as Antimalarial and Antipneumocystis Agents

Peptidomimetic imidazolidin-4-one derivatives of primaquine (imidazoquines) recently displayed in vitro activity against blood schizonts of a chloroquine-resistant strain of Plasmodium falciparum. Preliminary studies with a subset of such imidazoquines showed them to both block transmission of P. be...

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Veröffentlicht in:	Journal of medicinal chemistry 2009-12, Vol.52 (23), p.7800-7807
Hauptverfasser:	Vale, Nuno, Prudêncio, Miguel, Marques, Catarina A, Collins, Margaret S, Gut, Jiri, Nogueira, Fátima, Matos, Joana, Rosenthal, Philip J, Cushion, Melanie T, do Rosário, Virgílio E, Mota, Maria M, Moreira, Rui, Gomes, Paula
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antimalarials - blood Antimalarials - chemical synthesis Antimalarials - chemistry Antimalarials - pharmacology Antiparasitic agents Biological and medical sciences Cell Line Chemical Phenomena Disease Transmission, Infectious Drug Stability Female Humans Imidazoles - blood Imidazoles - chemical synthesis Imidazoles - chemistry Imidazoles - pharmacology Liver - parasitology Medical sciences Mice Pharmacology. Drug treatments Plasmodium falciparum - drug effects Pneumocystis carinii - drug effects
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