Evaluation of the mydriatic effect of intracameral lidocaine hydrochloride injection in eyes of clinically normal dogs
OBJECTIVE-To evaluate the mydriatic effect of intracameral injection of preservative-free 1% and 2% lidocaine hydrochloride solutions and determine the onset and duration of mydriasis according to the concentration and volume of lidocaine administered in healthy dogs. ANIMALS-5 healthy adult Beagles...
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Veröffentlicht in: | American journal of veterinary research 2009-12, Vol.70 (12), p.1521-1525 |
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creator | Park, Shin-Ae Kim, Na-Ra Park, Young-Woo Jeong, Man-Bok Kim, Won-Tae Kim, Se-Eun Kim, Tae-Hyun Seo, Kang-Moon |
description | OBJECTIVE-To evaluate the mydriatic effect of intracameral injection of preservative-free 1% and 2% lidocaine hydrochloride solutions and determine the onset and duration of mydriasis according to the concentration and volume of lidocaine administered in healthy dogs. ANIMALS-5 healthy adult Beagles weighing 7 to 10 kg, with no apparent ocular disease. PROCEDURES-A double-blind randomized 9-session crossover trial was designed. Both eyes were assigned to 9 treatments with a minimum 7-day washout period between treatments: 0.1, 0.2, and 0.3 mL of 2% lidocaine solution; 0.1, 0.2, and 0.3 mL of 1% lidocaine solution; and 0.1, 0.2, and 0.3 mL of balanced salt solution. Dogs were anesthetized, and the allocated treatment was injected intracamerally after aspiration of the same volume of aqueous humor from the anterior chamber of each eye. Two perpendicular pupil diameters were measured. Intraocular pressure, heart rate, respiratory rate, ECG readings, and end-tidal partial pressure of CO(2) were monitored. RESULTS-Intracameral injection of 1% or 2% lidocaine solutions in volumes of 0.1 to 0.3 mL induced a significant degree of mydriasis, and the effect was maintained for 74 to 142 minutes. Lidocaine injection had no significant effect on intraocular pressure, heart rate, respiratory rate, ECG readings, or end-tidal partial pressure of CO(2). CONCLUSIONS AND CLINICAL RELEVANCE-Intracameral lidocaine injection in healthy dogs induced mydriasis, the timing of which was affected by concentration and volume of lidocaine. This technique could serve as an alternative to topically administered mydriatics for intraocular surgery in dogs. |
doi_str_mv | 10.2460/ajvr.70.12.1521 |
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ANIMALS-5 healthy adult Beagles weighing 7 to 10 kg, with no apparent ocular disease. PROCEDURES-A double-blind randomized 9-session crossover trial was designed. Both eyes were assigned to 9 treatments with a minimum 7-day washout period between treatments: 0.1, 0.2, and 0.3 mL of 2% lidocaine solution; 0.1, 0.2, and 0.3 mL of 1% lidocaine solution; and 0.1, 0.2, and 0.3 mL of balanced salt solution. Dogs were anesthetized, and the allocated treatment was injected intracamerally after aspiration of the same volume of aqueous humor from the anterior chamber of each eye. Two perpendicular pupil diameters were measured. Intraocular pressure, heart rate, respiratory rate, ECG readings, and end-tidal partial pressure of CO(2) were monitored. RESULTS-Intracameral injection of 1% or 2% lidocaine solutions in volumes of 0.1 to 0.3 mL induced a significant degree of mydriasis, and the effect was maintained for 74 to 142 minutes. Lidocaine injection had no significant effect on intraocular pressure, heart rate, respiratory rate, ECG readings, or end-tidal partial pressure of CO(2). CONCLUSIONS AND CLINICAL RELEVANCE-Intracameral lidocaine injection in healthy dogs induced mydriasis, the timing of which was affected by concentration and volume of lidocaine. This technique could serve as an alternative to topically administered mydriatics for intraocular surgery in dogs.</description><identifier>ISSN: 0002-9645</identifier><identifier>EISSN: 1943-5681</identifier><identifier>DOI: 10.2460/ajvr.70.12.1521</identifier><identifier>PMID: 19951124</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Beagle ; Cross-Over Studies ; Dogs ; dosage ; Dose-Response Relationship, Drug ; drug evaluation ; drug injection ; eyes ; Female ; lidocaine ; Lidocaine - administration & dosage ; Lidocaine - pharmacology ; Male ; mydriasis ; Mydriasis - chemically induced ; Mydriatics - administration & dosage ; Mydriatics - pharmacology ; tears</subject><ispartof>American journal of veterinary research, 2009-12, Vol.70 (12), p.1521-1525</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-ad37c0e450d9ade38401598a602117879df59da8736738f948aa69ec46979d613</citedby><cites>FETCH-LOGICAL-c361t-ad37c0e450d9ade38401598a602117879df59da8736738f948aa69ec46979d613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19951124$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Shin-Ae</creatorcontrib><creatorcontrib>Kim, Na-Ra</creatorcontrib><creatorcontrib>Park, Young-Woo</creatorcontrib><creatorcontrib>Jeong, Man-Bok</creatorcontrib><creatorcontrib>Kim, Won-Tae</creatorcontrib><creatorcontrib>Kim, Se-Eun</creatorcontrib><creatorcontrib>Kim, Tae-Hyun</creatorcontrib><creatorcontrib>Seo, Kang-Moon</creatorcontrib><title>Evaluation of the mydriatic effect of intracameral lidocaine hydrochloride injection in eyes of clinically normal dogs</title><title>American journal of veterinary research</title><addtitle>Am J Vet Res</addtitle><description>OBJECTIVE-To evaluate the mydriatic effect of intracameral injection of preservative-free 1% and 2% lidocaine hydrochloride solutions and determine the onset and duration of mydriasis according to the concentration and volume of lidocaine administered in healthy dogs. ANIMALS-5 healthy adult Beagles weighing 7 to 10 kg, with no apparent ocular disease. PROCEDURES-A double-blind randomized 9-session crossover trial was designed. Both eyes were assigned to 9 treatments with a minimum 7-day washout period between treatments: 0.1, 0.2, and 0.3 mL of 2% lidocaine solution; 0.1, 0.2, and 0.3 mL of 1% lidocaine solution; and 0.1, 0.2, and 0.3 mL of balanced salt solution. Dogs were anesthetized, and the allocated treatment was injected intracamerally after aspiration of the same volume of aqueous humor from the anterior chamber of each eye. Two perpendicular pupil diameters were measured. Intraocular pressure, heart rate, respiratory rate, ECG readings, and end-tidal partial pressure of CO(2) were monitored. RESULTS-Intracameral injection of 1% or 2% lidocaine solutions in volumes of 0.1 to 0.3 mL induced a significant degree of mydriasis, and the effect was maintained for 74 to 142 minutes. Lidocaine injection had no significant effect on intraocular pressure, heart rate, respiratory rate, ECG readings, or end-tidal partial pressure of CO(2). CONCLUSIONS AND CLINICAL RELEVANCE-Intracameral lidocaine injection in healthy dogs induced mydriasis, the timing of which was affected by concentration and volume of lidocaine. This technique could serve as an alternative to topically administered mydriatics for intraocular surgery in dogs.</description><subject>Animals</subject><subject>Beagle</subject><subject>Cross-Over Studies</subject><subject>Dogs</subject><subject>dosage</subject><subject>Dose-Response Relationship, Drug</subject><subject>drug evaluation</subject><subject>drug injection</subject><subject>eyes</subject><subject>Female</subject><subject>lidocaine</subject><subject>Lidocaine - administration & dosage</subject><subject>Lidocaine - pharmacology</subject><subject>Male</subject><subject>mydriasis</subject><subject>Mydriasis - chemically induced</subject><subject>Mydriatics - administration & dosage</subject><subject>Mydriatics - pharmacology</subject><subject>tears</subject><issn>0002-9645</issn><issn>1943-5681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD1vFDEURS0EIptATQfTUc3Gz5_jEkWBIEWigNTWw_ZkvfKMgz270v77eLQrUT3pvnNvcQj5BHTLhKK3uD-WraZbYFuQDN6QDRjBe6kGeEs2lFLWGyXkFbmudU8psAHke3IFxkgAJjbkeH_EdMAl5rnLY7fsQjedfIktcV0Yx-CWNY_zUtDhFAqmLkWfHcY5dLuGZrdLuUQfGrRv-LoU5y6cQl2bLsU5Okzp1M25TK3u83P9QN6NmGr4eLk35On7_Z-7h_7x14-fd98ee8cVLD16rh0NQlJv0Ac-CArSDKgoA9CDNn6UxuOgudJ8GI0YEJUJTijTfgr4Dfl63n0p-d8h1MVOsbqQEs4hH6rVXIBSVPBG3p5JV3KtJYz2pcQJy8kCtatru7q2mlpgdnXdGp8v24e_U_D_-YvcBnw5AyNmi88lVvv0m1HgFDQwLil_BRWVhWw</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Park, Shin-Ae</creator><creator>Kim, Na-Ra</creator><creator>Park, Young-Woo</creator><creator>Jeong, Man-Bok</creator><creator>Kim, Won-Tae</creator><creator>Kim, Se-Eun</creator><creator>Kim, Tae-Hyun</creator><creator>Seo, Kang-Moon</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091201</creationdate><title>Evaluation of the mydriatic effect of intracameral lidocaine hydrochloride injection in eyes of clinically normal dogs</title><author>Park, Shin-Ae ; Kim, Na-Ra ; Park, Young-Woo ; Jeong, Man-Bok ; Kim, Won-Tae ; Kim, Se-Eun ; Kim, Tae-Hyun ; Seo, Kang-Moon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-ad37c0e450d9ade38401598a602117879df59da8736738f948aa69ec46979d613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Beagle</topic><topic>Cross-Over Studies</topic><topic>Dogs</topic><topic>dosage</topic><topic>Dose-Response Relationship, Drug</topic><topic>drug evaluation</topic><topic>drug injection</topic><topic>eyes</topic><topic>Female</topic><topic>lidocaine</topic><topic>Lidocaine - administration & dosage</topic><topic>Lidocaine - pharmacology</topic><topic>Male</topic><topic>mydriasis</topic><topic>Mydriasis - chemically induced</topic><topic>Mydriatics - administration & dosage</topic><topic>Mydriatics - pharmacology</topic><topic>tears</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Shin-Ae</creatorcontrib><creatorcontrib>Kim, Na-Ra</creatorcontrib><creatorcontrib>Park, Young-Woo</creatorcontrib><creatorcontrib>Jeong, Man-Bok</creatorcontrib><creatorcontrib>Kim, Won-Tae</creatorcontrib><creatorcontrib>Kim, Se-Eun</creatorcontrib><creatorcontrib>Kim, Tae-Hyun</creatorcontrib><creatorcontrib>Seo, Kang-Moon</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of veterinary research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Shin-Ae</au><au>Kim, Na-Ra</au><au>Park, Young-Woo</au><au>Jeong, Man-Bok</au><au>Kim, Won-Tae</au><au>Kim, Se-Eun</au><au>Kim, Tae-Hyun</au><au>Seo, Kang-Moon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the mydriatic effect of intracameral lidocaine hydrochloride injection in eyes of clinically normal dogs</atitle><jtitle>American journal of veterinary research</jtitle><addtitle>Am J Vet Res</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>70</volume><issue>12</issue><spage>1521</spage><epage>1525</epage><pages>1521-1525</pages><issn>0002-9645</issn><eissn>1943-5681</eissn><abstract>OBJECTIVE-To evaluate the mydriatic effect of intracameral injection of preservative-free 1% and 2% lidocaine hydrochloride solutions and determine the onset and duration of mydriasis according to the concentration and volume of lidocaine administered in healthy dogs. ANIMALS-5 healthy adult Beagles weighing 7 to 10 kg, with no apparent ocular disease. PROCEDURES-A double-blind randomized 9-session crossover trial was designed. Both eyes were assigned to 9 treatments with a minimum 7-day washout period between treatments: 0.1, 0.2, and 0.3 mL of 2% lidocaine solution; 0.1, 0.2, and 0.3 mL of 1% lidocaine solution; and 0.1, 0.2, and 0.3 mL of balanced salt solution. Dogs were anesthetized, and the allocated treatment was injected intracamerally after aspiration of the same volume of aqueous humor from the anterior chamber of each eye. Two perpendicular pupil diameters were measured. Intraocular pressure, heart rate, respiratory rate, ECG readings, and end-tidal partial pressure of CO(2) were monitored. RESULTS-Intracameral injection of 1% or 2% lidocaine solutions in volumes of 0.1 to 0.3 mL induced a significant degree of mydriasis, and the effect was maintained for 74 to 142 minutes. Lidocaine injection had no significant effect on intraocular pressure, heart rate, respiratory rate, ECG readings, or end-tidal partial pressure of CO(2). CONCLUSIONS AND CLINICAL RELEVANCE-Intracameral lidocaine injection in healthy dogs induced mydriasis, the timing of which was affected by concentration and volume of lidocaine. This technique could serve as an alternative to topically administered mydriatics for intraocular surgery in dogs.</abstract><cop>United States</cop><pmid>19951124</pmid><doi>10.2460/ajvr.70.12.1521</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals Beagle Cross-Over Studies Dogs dosage Dose-Response Relationship, Drug drug evaluation drug injection eyes Female lidocaine Lidocaine - administration & dosage Lidocaine - pharmacology Male mydriasis Mydriasis - chemically induced Mydriatics - administration & dosage Mydriatics - pharmacology tears |
title | Evaluation of the mydriatic effect of intracameral lidocaine hydrochloride injection in eyes of clinically normal dogs |
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