Selective Imaging of Damaged Bone Structure (Microcracks) Using a Targeting Supramolecular Eu(III) Complex As a Lanthanide Luminescent Contrast Agent
The synthesis and photophysical evaluation of a new supramolecular lanthanide complex is described which was developed as a luminescent contrast agent for bone structure analysis. We show that the Eu(III) emission of this complex is not pH dependent within the physiological pH range and its steady s...
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| Veröffentlicht in: | Journal of the American Chemical Society 2009-12, Vol.131 (48), p.17542-17543 |
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| container_end_page | 17543 |
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| container_issue | 48 |
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| container_title | Journal of the American Chemical Society |
| container_volume | 131 |
| creator | McMahon, Brian Mauer, Peter McCoy, Colin P Lee, T. Clive Gunnlaugsson, Thorfinnur |
| description | The synthesis and photophysical evaluation of a new supramolecular lanthanide complex is described which was developed as a luminescent contrast agent for bone structure analysis. We show that the Eu(III) emission of this complex is not pH dependent within the physiological pH range and its steady state emission is not significantly modulated by a series of group I and II as well as d-metal ions and that this agent can be successfully employed to image mechanically formed cracks (scratches) in bone samples after 4 or 24 h, using confocal laser-scanning microscopy. |
| doi_str_mv | 10.1021/ja908006r |
| format | Article |
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We show that the Eu(III) emission of this complex is not pH dependent within the physiological pH range and its steady state emission is not significantly modulated by a series of group I and II as well as d-metal ions and that this agent can be successfully employed to image mechanically formed cracks (scratches) in bone samples after 4 or 24 h, using confocal laser-scanning microscopy.</description><subject>Animals</subject><subject>Bone and Bones - metabolism</subject><subject>Bone and Bones - pathology</subject><subject>Calcium - metabolism</subject><subject>Cattle</subject><subject>Contrast Media - chemistry</subject><subject>Contrast Media - metabolism</subject><subject>Durapatite - metabolism</subject><subject>Europium - chemistry</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Imino Acids - chemistry</subject><subject>Lanthanoid Series Elements - chemistry</subject><subject>Luminescent Agents - chemistry</subject><subject>Luminescent Agents - metabolism</subject><subject>Microscopy, Confocal</subject><subject>Molecular Imaging - methods</subject><subject>Organometallic Compounds - chemistry</subject><subject>Organometallic Compounds - metabolism</subject><issn>0002-7863</issn><issn>1520-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc1OGzEUhS1UBIF2wQtU3lSQxYDt-Ym9DIG2IwWxCKxHF_tOmHTGE_xTtQ_S962jRO2G1b1H-nR0z7mEXHB2zZngNxtQTDJWuSMy4aVgWclF9YFMGGMim8kqPyVn3m-SLITkJ-SUK8WrQsoJ-bPCHnXofiKtB1h3dk3Hlt5B2tHQ29EiXQUXdYgO6dVDp92oHegffkqf_Y4G-gRujWG3r-LWwTAmw9iDo_fxqq7rKV2Mw7bHX3TuE70EG17BdgbpMg6dRa_RhsTY4MAHOl8n-ZEct9B7_HSY5-T56_3T4nu2fPxWL-bLDHLJQibYTIIWKXwxaytVAQfJCmYKTG0UrTYCKqWNydFwrUtRlhqgVS9GGoVMqfycXO59t258i-hDM3Tpnr4Hi2P0zSwveFUqLhM53ZOpAO8dts3WdQO43w1nze4Jzb8nJPbzwTW-DGj-k4fWE_BlD4D2zWaMzqaQ7xj9BYUojxA</recordid><startdate>20091209</startdate><enddate>20091209</enddate><creator>McMahon, Brian</creator><creator>Mauer, Peter</creator><creator>McCoy, Colin P</creator><creator>Lee, T. 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Soc</addtitle><date>2009-12-09</date><risdate>2009</risdate><volume>131</volume><issue>48</issue><spage>17542</spage><epage>17543</epage><pages>17542-17543</pages><issn>0002-7863</issn><eissn>1520-5126</eissn><abstract>The synthesis and photophysical evaluation of a new supramolecular lanthanide complex is described which was developed as a luminescent contrast agent for bone structure analysis. We show that the Eu(III) emission of this complex is not pH dependent within the physiological pH range and its steady state emission is not significantly modulated by a series of group I and II as well as d-metal ions and that this agent can be successfully employed to image mechanically formed cracks (scratches) in bone samples after 4 or 24 h, using confocal laser-scanning microscopy.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>19916488</pmid><doi>10.1021/ja908006r</doi><tpages>2</tpages></addata></record> |
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| ispartof | Journal of the American Chemical Society, 2009-12, Vol.131 (48), p.17542-17543 |
| issn | 0002-7863 1520-5126 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Animals Bone and Bones - metabolism Bone and Bones - pathology Calcium - metabolism Cattle Contrast Media - chemistry Contrast Media - metabolism Durapatite - metabolism Europium - chemistry Humans Hydrogen-Ion Concentration Imino Acids - chemistry Lanthanoid Series Elements - chemistry Luminescent Agents - chemistry Luminescent Agents - metabolism Microscopy, Confocal Molecular Imaging - methods Organometallic Compounds - chemistry Organometallic Compounds - metabolism |
| title | Selective Imaging of Damaged Bone Structure (Microcracks) Using a Targeting Supramolecular Eu(III) Complex As a Lanthanide Luminescent Contrast Agent |
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