Embryonic Stem Cells Overexpressing Pitx2c Engraft in Infarcted Myocardium and Improve Cardiac Function

This study investigated the effects on cardiomyocyte differentiation of embryonic stem cells by the overexpression of the transcription factor, Pitx2c, and examined the effects of transplantation of these differentiated cells on cardiac function in a mouse model of myocardial infarction. Pitx2c over...

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Veröffentlicht in:	International Heart Journal 2009, Vol.50(6), pp.783-799
Hauptverfasser:	Guddati, AK, Otero, José Javier, Kessler, Eric, Aistrup, Gary, Wasserstrom, J. Andrew, Han, Xiaoqiang, Webber, Matthew J., Stupp, Samuel I., Lomasney, Jon W., Kessler, John A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Calcium - analysis Cardiac differentiation Cell Differentiation Cell transplantation Cells, Cultured Embryonic stem cells Embryonic Stem Cells - chemistry Embryonic Stem Cells - physiology Embryonic Stem Cells - transplantation Female Heart - physiology Immunohistochemistry Mice Myocardial infarction Myocardial Infarction - physiopathology Myocardial Infarction - surgery Myocardium - cytology Pitx2c Reverse Transcriptase Polymerase Chain Reaction RNA - analysis Tissue Scaffolds Transcription Factors - analysis
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