Nanoparticles formed from PNIPAM- g-PEO copolymers in the presence of indomethacin

Biocompatible double-hydrophilic PNIPAM- g-PEO copolymers containing 0.3–3.2 mol% PEO grafts were synthesized and utilized to prepare indomethacin (IMC)-loaded core–shell nanoparticles by dialysis and nanoprecipitation methods. IMC loading was conducted at room temperature using the organic solvents...

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Veröffentlicht in:	International journal of pharmaceutics 2010-01, Vol.384 (1), p.154-164
Hauptverfasser:	Michailova, V., Berlinova, I., Iliev, P., Ivanov, L., Titeva, S., Momekov, G., Dimitrov, I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic Resins - chemical synthesis Acrylic Resins - pharmacokinetics Biological and medical sciences Cell Line Cononsolvency Double-hydrophilic graft copolymers Drug release General pharmacology Humans Indomethacin Indomethacin - chemical synthesis Indomethacin - pharmacokinetics Medical sciences Nanoparticles Nanoparticles - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Poly( N-isopropylacrylamide)- g-poly(ethylene oxide) Polyethylene Glycols - chemical synthesis Polyethylene Glycols - pharmacokinetics Polymers - chemical synthesis Polymers - pharmacokinetics
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