VHL inactivation is an important pathway for the development of malignant sporadic pancreatic endocrine tumors

A small subset of familial pancreatic endocrine tumors (PET) arises in patients with von Hippel–Lindau syndrome and these tumors may have an adverse outcome compared to other familial PET. Sporadic PET rarely harbors somatic VHL mutations, but the chromosomal location of the VHL gene is frequently d...

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Veröffentlicht in:	Endocrine-related cancer 2009-12, Vol.16 (4), p.1219-1227
Hauptverfasser:	Schmitt, A M, Schmid, S, Rudolph, T, Anlauf, M, Prinz, C, Klöppel, G, Moch, H, Heitz, P U, Komminoth, P, Perren, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Neoplasm - genetics Antigens, Neoplasm - metabolism Carbonic Anhydrase IX Carbonic Anhydrases - genetics Carbonic Anhydrases - metabolism DNA Methylation Endocrine Gland Neoplasms - genetics Endocrine Gland Neoplasms - metabolism Endocrine Gland Neoplasms - pathology Gene Deletion Glucose Transporter Type 1 - genetics Glucose Transporter Type 1 - metabolism Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Immunoenzyme Techniques In Situ Hybridization, Fluorescence Mutation - genetics Pancreas - metabolism Pancreas - pathology Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Prognosis Promoter Regions, Genetic Regular papers Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Survival Rate Von Hippel-Lindau Tumor Suppressor Protein - antagonists & inhibitors Von Hippel-Lindau Tumor Suppressor Protein - genetics Von Hippel-Lindau Tumor Suppressor Protein - metabolism
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