Airway Epithelial Changes in Smokers but Not in Ex-Smokers with Asthma

Smoking has detrimental effects on asthma outcome, such as increased cough, wheezing, sputum production, and frequency of asthma attacks. This results in accelerated lung function decline. The underlying pathological process of smoke-induced deterioration of asthma is unknown. To compare bronchial i...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2009-12, Vol.180 (12), p.1170-1178
Hauptverfasser:	Broekema, Martine, ten Hacken, Nick H. T, Volbeda, Franke, Lodewijk, Monique E, Hylkema, Machteld N, Postma, Dirkje S, Timens, Wim
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Airway management Airway Remodeling Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Asthma Asthma - complications Asthma - metabolism Asthma - pathology Biological and medical sciences Biopsy Bronchi - pathology Bronchi - ultrastructure Bronchoscopy Chronic obstructive pulmonary disease Cigarettes Cohort Studies Dyspnea - etiology Emergency and intensive respiratory care Female Forced Expiratory Volume Histamine Humans Inflammation Inflammation - etiology Inflammation - pathology Intensive care medicine Male Medical sciences Middle Aged Neutrophils Nitric oxide Nitric Oxide - metabolism Questionnaires Respiratory Function Tests Respiratory Mucosa - metabolism Respiratory Mucosa - pathology Smoking - adverse effects Smoking - metabolism Smoking - pathology Smoking cessation Smoking Cessation - statistics & numerical data Sputum Surveys and Questionnaires Young Adult
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