Neutrophil granulocytes promote the migratory activity of MDA-MB-468 human breast carcinoma cells via ICAM-1

Tumor infiltrating neutrophil granulocytes do not only exhibit tumor eliminating functions but also promote tumor progression. We have recently shown that neutrophil granulocytes can serve as linking cells for the adhesion of MDA-MB-468 breast carcinoma cells to pulmonary endothelium. Neutrophil gra...

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Veröffentlicht in:	Experimental cell research 2010, Vol.316 (1), p.138-148
Hauptverfasser:	Strell, Carina, Lang, Kerstin, Niggemann, Bernd, Zaenker, Kurt S., Entschladen, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Breast cancer Breast Neoplasms - pathology Calcium Signaling - physiology Cell adhesion & migration Cell Communication - physiology Cell Line, Tumor Cell migration Cell Movement - drug effects Cell Movement - physiology Chemokine CXCL1 - antagonists & inhibitors Chemokine CXCL1 - metabolism Coculture Techniques Cross-Linking Reagents - pharmacology Culture Media, Conditioned - metabolism Culture Media, Conditioned - pharmacology Cytokines Estrenes - pharmacology Female Focal adhesion kinase Focal Adhesion Kinase 1 - metabolism Gene expression Humans ICAM-1 Intercellular Adhesion Molecule-1 - physiology Interleukin-8 - antagonists & inhibitors Interleukin-8 - metabolism Macrophage-1 Antigen - metabolism Metastasis formation Neutrophil granulocytes Neutrophils - cytology Neutrophils - drug effects Neutrophils - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Paxillin Paxillin - metabolism Phosphorylation - drug effects Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Protein Kinase Inhibitors - pharmacology Pyrimidines - pharmacology Pyrrolidinones - pharmacology rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - metabolism RNA, Small Interfering - genetics Signal transduction Signal Transduction - drug effects Signal Transduction - physiology src-Family Kinases - antagonists & inhibitors src-Family Kinases - metabolism Thapsigargin - pharmacology
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