Effects of oral magnesium supplementation on insulin sensitivity and blood pressure in normo-magnesemic nondiabetic overweight Korean adults

Abstract Background and aim Little is known about the effect of magnesium on insulin sensitivity and BP in healthy individuals. Therefore, we investigated whether magnesium could improve insulin sensitivity and blood pressure (BP) in normo-magnesemic nondiabetic overweight adults. Methods and result...

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Veröffentlicht in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2009-12, Vol.19 (11), p.781-788
Hauptverfasser: Lee, S, Park, H.K, Son, S.P, Lee, C.W, Kim, I.J, Kim, H.J
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container_end_page 788
container_issue 11
container_start_page 781
container_title Nutrition, metabolism, and cardiovascular diseases
container_volume 19
creator Lee, S
Park, H.K
Son, S.P
Lee, C.W
Kim, I.J
Kim, H.J
description Abstract Background and aim Little is known about the effect of magnesium on insulin sensitivity and BP in healthy individuals. Therefore, we investigated whether magnesium could improve insulin sensitivity and blood pressure (BP) in normo-magnesemic nondiabetic overweight adults. Methods and results In a double-blinded, placebo-controlled, randomized trial, a total of 155 participants (BMI ≥ 23 kg/m2 ) received either 12.3 mmol (300 mg) of elemental magnesium in the form of magnesium oxide ( n = 75) or placebo ( n = 80) each day for 12 weeks, constituting the intent-to-treat population. A repeated-measures ANOVA was used to evaluate the between-group changes in variables during the study. The baseline characteristics between the intervention and control groups were similar. There were no significant differences between the groups in the pattern of change of the homeostasis model assessment insulin resistance index, BP over time during the 12-week study. In subgroup analysis, magnesium supplementation ( n = 8, 27, and 24, respectively) lowered BP much more than placebo ( n = 16, 29, and 25, respectively) in those subjects whose systolic BP ≥ 140 mmHg, diastolic BP 80–90 mmHg, and diastolic BP ≥ 90 mmHg at the start of the study ( P = 0.016, 0.043, and 0.023, respectively); in comparison, those subjects whose initial BP reading was low at baseline did not show a change in BP. No significant adverse events related to magnesium supplementation were recorded. Conclusions These results suggested that magnesium supplementation does not reduce BP and enhance insulin sensitivity in normo-magnesemic nondiabetic overweight people. However, it appears that magnesium supplementation may lower BP in healthy adults with higher BP.
doi_str_mv 10.1016/j.numecd.2009.01.002
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Therefore, we investigated whether magnesium could improve insulin sensitivity and blood pressure (BP) in normo-magnesemic nondiabetic overweight adults. Methods and results In a double-blinded, placebo-controlled, randomized trial, a total of 155 participants (BMI ≥ 23 kg/m2 ) received either 12.3 mmol (300 mg) of elemental magnesium in the form of magnesium oxide ( n = 75) or placebo ( n = 80) each day for 12 weeks, constituting the intent-to-treat population. A repeated-measures ANOVA was used to evaluate the between-group changes in variables during the study. The baseline characteristics between the intervention and control groups were similar. There were no significant differences between the groups in the pattern of change of the homeostasis model assessment insulin resistance index, BP over time during the 12-week study. In subgroup analysis, magnesium supplementation ( n = 8, 27, and 24, respectively) lowered BP much more than placebo ( n = 16, 29, and 25, respectively) in those subjects whose systolic BP ≥ 140 mmHg, diastolic BP 80–90 mmHg, and diastolic BP ≥ 90 mmHg at the start of the study ( P = 0.016, 0.043, and 0.023, respectively); in comparison, those subjects whose initial BP reading was low at baseline did not show a change in BP. No significant adverse events related to magnesium supplementation were recorded. Conclusions These results suggested that magnesium supplementation does not reduce BP and enhance insulin sensitivity in normo-magnesemic nondiabetic overweight people. However, it appears that magnesium supplementation may lower BP in healthy adults with higher BP.</description><identifier>ISSN: 0939-4753</identifier><identifier>EISSN: 1590-3729</identifier><identifier>DOI: 10.1016/j.numecd.2009.01.002</identifier><identifier>PMID: 19359148</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Administration, Oral ; Adult ; Asian Continental Ancestry Group ; Biomarkers - blood ; Blood Glucose - drug effects ; Blood pressure ; Blood Pressure - drug effects ; Cardiovascular ; Dietary Supplements ; Double-Blind Method ; Female ; Humans ; Insulin - blood ; Insulin Resistance - ethnology ; Insulin sensitivity ; Lipids - blood ; Magnesium ; Magnesium Oxide - administration &amp; dosage ; Magnesium Oxide - blood ; Male ; Middle Aged ; Overweight ; Overweight - blood ; Overweight - drug therapy ; Overweight - ethnology ; Overweight - physiopathology ; Republic of Korea - epidemiology ; Time Factors</subject><ispartof>Nutrition, metabolism, and cardiovascular diseases, 2009-12, Vol.19 (11), p.781-788</ispartof><rights>Elsevier B.V.</rights><rights>2009 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-4ed0a75392c014c2df8412fd7b827cd0f93e8c2be2ab4f5e5985e74b1ac22b5c3</citedby><cites>FETCH-LOGICAL-c416t-4ed0a75392c014c2df8412fd7b827cd0f93e8c2be2ab4f5e5985e74b1ac22b5c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.numecd.2009.01.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19359148$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, S</creatorcontrib><creatorcontrib>Park, H.K</creatorcontrib><creatorcontrib>Son, S.P</creatorcontrib><creatorcontrib>Lee, C.W</creatorcontrib><creatorcontrib>Kim, I.J</creatorcontrib><creatorcontrib>Kim, H.J</creatorcontrib><title>Effects of oral magnesium supplementation on insulin sensitivity and blood pressure in normo-magnesemic nondiabetic overweight Korean adults</title><title>Nutrition, metabolism, and cardiovascular diseases</title><addtitle>Nutr Metab Cardiovasc Dis</addtitle><description>Abstract Background and aim Little is known about the effect of magnesium on insulin sensitivity and BP in healthy individuals. Therefore, we investigated whether magnesium could improve insulin sensitivity and blood pressure (BP) in normo-magnesemic nondiabetic overweight adults. Methods and results In a double-blinded, placebo-controlled, randomized trial, a total of 155 participants (BMI ≥ 23 kg/m2 ) received either 12.3 mmol (300 mg) of elemental magnesium in the form of magnesium oxide ( n = 75) or placebo ( n = 80) each day for 12 weeks, constituting the intent-to-treat population. A repeated-measures ANOVA was used to evaluate the between-group changes in variables during the study. The baseline characteristics between the intervention and control groups were similar. There were no significant differences between the groups in the pattern of change of the homeostasis model assessment insulin resistance index, BP over time during the 12-week study. In subgroup analysis, magnesium supplementation ( n = 8, 27, and 24, respectively) lowered BP much more than placebo ( n = 16, 29, and 25, respectively) in those subjects whose systolic BP ≥ 140 mmHg, diastolic BP 80–90 mmHg, and diastolic BP ≥ 90 mmHg at the start of the study ( P = 0.016, 0.043, and 0.023, respectively); in comparison, those subjects whose initial BP reading was low at baseline did not show a change in BP. No significant adverse events related to magnesium supplementation were recorded. Conclusions These results suggested that magnesium supplementation does not reduce BP and enhance insulin sensitivity in normo-magnesemic nondiabetic overweight people. 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Park, H.K ; Son, S.P ; Lee, C.W ; Kim, I.J ; Kim, H.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-4ed0a75392c014c2df8412fd7b827cd0f93e8c2be2ab4f5e5985e74b1ac22b5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Asian Continental Ancestry Group</topic><topic>Biomarkers - blood</topic><topic>Blood Glucose - drug effects</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiovascular</topic><topic>Dietary Supplements</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Insulin Resistance - ethnology</topic><topic>Insulin sensitivity</topic><topic>Lipids - blood</topic><topic>Magnesium</topic><topic>Magnesium Oxide - administration &amp; dosage</topic><topic>Magnesium Oxide - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Overweight</topic><topic>Overweight - blood</topic><topic>Overweight - drug therapy</topic><topic>Overweight - ethnology</topic><topic>Overweight - physiopathology</topic><topic>Republic of Korea - epidemiology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, S</creatorcontrib><creatorcontrib>Park, H.K</creatorcontrib><creatorcontrib>Son, S.P</creatorcontrib><creatorcontrib>Lee, C.W</creatorcontrib><creatorcontrib>Kim, I.J</creatorcontrib><creatorcontrib>Kim, H.J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, S</au><au>Park, H.K</au><au>Son, S.P</au><au>Lee, C.W</au><au>Kim, I.J</au><au>Kim, H.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of oral magnesium supplementation on insulin sensitivity and blood pressure in normo-magnesemic nondiabetic overweight Korean adults</atitle><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle><addtitle>Nutr Metab Cardiovasc Dis</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>19</volume><issue>11</issue><spage>781</spage><epage>788</epage><pages>781-788</pages><issn>0939-4753</issn><eissn>1590-3729</eissn><abstract>Abstract Background and aim Little is known about the effect of magnesium on insulin sensitivity and BP in healthy individuals. Therefore, we investigated whether magnesium could improve insulin sensitivity and blood pressure (BP) in normo-magnesemic nondiabetic overweight adults. Methods and results In a double-blinded, placebo-controlled, randomized trial, a total of 155 participants (BMI ≥ 23 kg/m2 ) received either 12.3 mmol (300 mg) of elemental magnesium in the form of magnesium oxide ( n = 75) or placebo ( n = 80) each day for 12 weeks, constituting the intent-to-treat population. A repeated-measures ANOVA was used to evaluate the between-group changes in variables during the study. The baseline characteristics between the intervention and control groups were similar. There were no significant differences between the groups in the pattern of change of the homeostasis model assessment insulin resistance index, BP over time during the 12-week study. In subgroup analysis, magnesium supplementation ( n = 8, 27, and 24, respectively) lowered BP much more than placebo ( n = 16, 29, and 25, respectively) in those subjects whose systolic BP ≥ 140 mmHg, diastolic BP 80–90 mmHg, and diastolic BP ≥ 90 mmHg at the start of the study ( P = 0.016, 0.043, and 0.023, respectively); in comparison, those subjects whose initial BP reading was low at baseline did not show a change in BP. No significant adverse events related to magnesium supplementation were recorded. Conclusions These results suggested that magnesium supplementation does not reduce BP and enhance insulin sensitivity in normo-magnesemic nondiabetic overweight people. However, it appears that magnesium supplementation may lower BP in healthy adults with higher BP.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>19359148</pmid><doi>10.1016/j.numecd.2009.01.002</doi><tpages>8</tpages></addata></record>
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source MEDLINE; Access via ScienceDirect (Elsevier)
subjects Administration, Oral
Adult
Asian Continental Ancestry Group
Biomarkers - blood
Blood Glucose - drug effects
Blood pressure
Blood Pressure - drug effects
Cardiovascular
Dietary Supplements
Double-Blind Method
Female
Humans
Insulin - blood
Insulin Resistance - ethnology
Insulin sensitivity
Lipids - blood
Magnesium
Magnesium Oxide - administration & dosage
Magnesium Oxide - blood
Male
Middle Aged
Overweight
Overweight - blood
Overweight - drug therapy
Overweight - ethnology
Overweight - physiopathology
Republic of Korea - epidemiology
Time Factors
title Effects of oral magnesium supplementation on insulin sensitivity and blood pressure in normo-magnesemic nondiabetic overweight Korean adults
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