Phellinins A1 and A2, new styrylpyrones from the culture broth of Phellinus sp. KACC93057P: I. Fermentation, taxonomy, isolation and biological properties
Novel styrylpyrones, phellinins A1 and A2, were isolated together with known styrylpyrone compounds, hispidin and 1,1-distyrylpyrylethan, from the cultured broth of Phellinus sp. KACC93057P. These compounds were purified by solvent partition, Sephadex LH-20 column chromatography, C 18 -solid phase e...
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| Veröffentlicht in: | Journal of antibiotics 2009-11, Vol.62 (11), p.631-634 |
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| creator | Lee, In-Kyoung Seo, Geon-Sik Jeon, Nak Beom Kang, Hee-Wan Yun, Bong-Sik |
| description | Novel styrylpyrones, phellinins A1 and A2, were isolated together with known styrylpyrone compounds, hispidin and 1,1-distyrylpyrylethan, from the cultured broth of
Phellinus
sp. KACC93057P. These compounds were purified by solvent partition, Sephadex LH-20 column chromatography, C
18
-solid phase extraction and finally by reversed-phase (ODS) TLC. To identify the phellinin producer
Phellinus
sp. KACC93057P, the ribosomal DNA (rDNA) internal transcribed space regions containing 5.8 rDNA were sequenced and compared with those of the known
Phellinus
isolates.
Phellinus
sp. KACC93057P was 94.8% identical to
P. baumii
and
P. linteus
, all of which did not produce phellinins A1 and A2. These compounds significantly scavenged free radicals such as 1,1-diphenyl-2-picrylhydrazyl, 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) and superoxide. |
| doi_str_mv | 10.1038/ja.2009.82 |
| format | Article |
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Phellinus
sp. KACC93057P. These compounds were purified by solvent partition, Sephadex LH-20 column chromatography, C
18
-solid phase extraction and finally by reversed-phase (ODS) TLC. To identify the phellinin producer
Phellinus
sp. KACC93057P, the ribosomal DNA (rDNA) internal transcribed space regions containing 5.8 rDNA were sequenced and compared with those of the known
Phellinus
isolates.
Phellinus
sp. KACC93057P was 94.8% identical to
P. baumii
and
P. linteus
, all of which did not produce phellinins A1 and A2. These compounds significantly scavenged free radicals such as 1,1-diphenyl-2-picrylhydrazyl, 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) and superoxide.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.1038/ja.2009.82</identifier><identifier>PMID: 19713993</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Bacteriology ; Basidiomycota - classification ; Basidiomycota - metabolism ; Biological properties ; Biomedical and Life Sciences ; Bioorganic Chemistry ; Chromatography, High Pressure Liquid ; Fermentation ; Free Radical Scavengers - isolation & purification ; Free Radical Scavengers - pharmacology ; Life Sciences ; Medicinal Chemistry ; Microbiology ; Organic Chemistry ; original-article ; Pyrones - isolation & purification ; Pyrones - pharmacology ; Styrenes - isolation & purification ; Styrenes - pharmacology</subject><ispartof>Journal of antibiotics, 2009-11, Vol.62 (11), p.631-634</ispartof><rights>Japan Antibiotics Research Association 2009</rights><rights>Copyright Nature Publishing Group Nov 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-39a892bf109d9d80be0d2b831329de454eb2fa2732b2ad4db533873e626af903</citedby><cites>FETCH-LOGICAL-c415t-39a892bf109d9d80be0d2b831329de454eb2fa2732b2ad4db533873e626af903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19713993$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, In-Kyoung</creatorcontrib><creatorcontrib>Seo, Geon-Sik</creatorcontrib><creatorcontrib>Jeon, Nak Beom</creatorcontrib><creatorcontrib>Kang, Hee-Wan</creatorcontrib><creatorcontrib>Yun, Bong-Sik</creatorcontrib><title>Phellinins A1 and A2, new styrylpyrones from the culture broth of Phellinus sp. KACC93057P: I. Fermentation, taxonomy, isolation and biological properties</title><title>Journal of antibiotics</title><addtitle>J Antibiot</addtitle><addtitle>J Antibiot (Tokyo)</addtitle><description>Novel styrylpyrones, phellinins A1 and A2, were isolated together with known styrylpyrone compounds, hispidin and 1,1-distyrylpyrylethan, from the cultured broth of
Phellinus
sp. KACC93057P. These compounds were purified by solvent partition, Sephadex LH-20 column chromatography, C
18
-solid phase extraction and finally by reversed-phase (ODS) TLC. To identify the phellinin producer
Phellinus
sp. KACC93057P, the ribosomal DNA (rDNA) internal transcribed space regions containing 5.8 rDNA were sequenced and compared with those of the known
Phellinus
isolates.
Phellinus
sp. KACC93057P was 94.8% identical to
P. baumii
and
P. linteus
, all of which did not produce phellinins A1 and A2. These compounds significantly scavenged free radicals such as 1,1-diphenyl-2-picrylhydrazyl, 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) and superoxide.</description><subject>Bacteriology</subject><subject>Basidiomycota - classification</subject><subject>Basidiomycota - metabolism</subject><subject>Biological properties</subject><subject>Biomedical and Life Sciences</subject><subject>Bioorganic Chemistry</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Fermentation</subject><subject>Free Radical Scavengers - isolation & purification</subject><subject>Free Radical Scavengers - pharmacology</subject><subject>Life Sciences</subject><subject>Medicinal Chemistry</subject><subject>Microbiology</subject><subject>Organic Chemistry</subject><subject>original-article</subject><subject>Pyrones - isolation & purification</subject><subject>Pyrones - pharmacology</subject><subject>Styrenes - isolation & purification</subject><subject>Styrenes - pharmacology</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkc1u1DAURi0EokNhwwMgSyyQyiT4Jxnb7EYjChWV6KJ7y0luOh4ldrAdlbwKT1u3MxIIVpauj853rz6E3lJSUsLlp4MpGSGqlOwZWlEpaUGrjXqOVoQwWkjJyBl6FeOBEC64kC_RGVWCcqX4Cv2-2cMwWGddxFuKjevwlq2xg3sc0xKWYVqCdxBxH_yI0x5wOw9pDoCb4NMe-x6fDHPEcSrx9-1upzipxc1nfFXiSwgjuGSS9W6Nk_nlnR-XNbbRD0_Dp8jG-sHf2dYMeAp-gpAsxNfoRW-GCG9O7zm6vfxyu_tWXP_4erXbXhdtRetUcGWkYk1PiepUJ0kDpGON5JQz1UFVV9Cw3jDBWcNMV3VNzbkUHDZsY3pF-Dn6cNTm5J8zxKRHG9t8knHg56gFzzFCCZHJ9_-QBz8Hl3fTVEiRibqSmbo4Um3wMQbo9RTsaMKiKdGPfemD0Y99acky_O6knJsRuj_oqaAMfDwCMX-5Owh_Zf6vewDPyJ40</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Lee, In-Kyoung</creator><creator>Seo, Geon-Sik</creator><creator>Jeon, Nak Beom</creator><creator>Kang, Hee-Wan</creator><creator>Yun, Bong-Sik</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>Phellinins A1 and A2, new styrylpyrones from the culture broth of Phellinus sp. KACC93057P: I. Fermentation, taxonomy, isolation and biological properties</title><author>Lee, In-Kyoung ; Seo, Geon-Sik ; Jeon, Nak Beom ; Kang, Hee-Wan ; Yun, Bong-Sik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-39a892bf109d9d80be0d2b831329de454eb2fa2732b2ad4db533873e626af903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Bacteriology</topic><topic>Basidiomycota - classification</topic><topic>Basidiomycota - metabolism</topic><topic>Biological properties</topic><topic>Biomedical and Life Sciences</topic><topic>Bioorganic Chemistry</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Fermentation</topic><topic>Free Radical Scavengers - isolation & purification</topic><topic>Free Radical Scavengers - pharmacology</topic><topic>Life Sciences</topic><topic>Medicinal Chemistry</topic><topic>Microbiology</topic><topic>Organic Chemistry</topic><topic>original-article</topic><topic>Pyrones - isolation & purification</topic><topic>Pyrones - pharmacology</topic><topic>Styrenes - isolation & purification</topic><topic>Styrenes - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, In-Kyoung</creatorcontrib><creatorcontrib>Seo, Geon-Sik</creatorcontrib><creatorcontrib>Jeon, Nak Beom</creatorcontrib><creatorcontrib>Kang, Hee-Wan</creatorcontrib><creatorcontrib>Yun, Bong-Sik</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, In-Kyoung</au><au>Seo, Geon-Sik</au><au>Jeon, Nak Beom</au><au>Kang, Hee-Wan</au><au>Yun, Bong-Sik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phellinins A1 and A2, new styrylpyrones from the culture broth of Phellinus sp. KACC93057P: I. Fermentation, taxonomy, isolation and biological properties</atitle><jtitle>Journal of antibiotics</jtitle><stitle>J Antibiot</stitle><addtitle>J Antibiot (Tokyo)</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>62</volume><issue>11</issue><spage>631</spage><epage>634</epage><pages>631-634</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>Novel styrylpyrones, phellinins A1 and A2, were isolated together with known styrylpyrone compounds, hispidin and 1,1-distyrylpyrylethan, from the cultured broth of
Phellinus
sp. KACC93057P. These compounds were purified by solvent partition, Sephadex LH-20 column chromatography, C
18
-solid phase extraction and finally by reversed-phase (ODS) TLC. To identify the phellinin producer
Phellinus
sp. KACC93057P, the ribosomal DNA (rDNA) internal transcribed space regions containing 5.8 rDNA were sequenced and compared with those of the known
Phellinus
isolates.
Phellinus
sp. KACC93057P was 94.8% identical to
P. baumii
and
P. linteus
, all of which did not produce phellinins A1 and A2. These compounds significantly scavenged free radicals such as 1,1-diphenyl-2-picrylhydrazyl, 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) and superoxide.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>19713993</pmid><doi>10.1038/ja.2009.82</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | Journal of antibiotics, 2009-11, Vol.62 (11), p.631-634 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_734157977 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Bacteriology Basidiomycota - classification Basidiomycota - metabolism Biological properties Biomedical and Life Sciences Bioorganic Chemistry Chromatography, High Pressure Liquid Fermentation Free Radical Scavengers - isolation & purification Free Radical Scavengers - pharmacology Life Sciences Medicinal Chemistry Microbiology Organic Chemistry original-article Pyrones - isolation & purification Pyrones - pharmacology Styrenes - isolation & purification Styrenes - pharmacology |
| title | Phellinins A1 and A2, new styrylpyrones from the culture broth of Phellinus sp. KACC93057P: I. Fermentation, taxonomy, isolation and biological properties |
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