The effect of selected patient's characteristics on the choice of antihypertensive medication in the elderly in Slovakia
Purpose The aim of the present study was to determine which patient‐related characteristics influence the selection of the antihypertensive drug class in elderly patients in Slovakia. Methods The sample for our study (n = 401) was selected from 1045 patients admitted to the Department of Internal Me...
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| Veröffentlicht in: | Pharmacoepidemiology and drug safety 2009-12, Vol.18 (12), p.1199-1205 |
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| creator | Wawruch, Martin Dukat, Andrej Murin, Jan Wsolova, Ladislava Kuzelova, Magdalena Macugova, Agata Wimmer Jr, Gejza Shah, Rashmi |
| description | Purpose
The aim of the present study was to determine which patient‐related characteristics influence the selection of the antihypertensive drug class in elderly patients in Slovakia.
Methods
The sample for our study (n = 401) was selected from 1045 patients admitted to the Department of Internal Medicine of a general hospital during the period of 1 December 2003—31 March 2005. Patients aged 65 or more with documented arterial hypertension and treated with at least one antihypertensive drug were enrolled in our retrospective study. Specific socio‐demographic and clinical characteristics as well as cardiovascular comorbid conditions were evaluated as potential factors that could have influenced the choice of antihypertensive drug class.
Results
The most frequently prescribed antihypertensive drugs were angiotensin‐converting enzyme (ACE) inhibitors and diuretics (61.8% and 60.1% of patients, respectively). Patients aged ≥ 85 years had lower probability of ACE inhibitors prescription (OR = 0.49). Females had higher chance of calcium channel blockers use (OR = 3.84) and lower odds of diuretics administration (OR = 0.50). In patients living alone, ACE inhibitors were preferred (OR = 2.16). The use of diuretics was more frequent in polymorbid patients (OR = 1.95). Immobile patients had lower chance of being prescribed beta‐blockers and calcium channel blockers (OR = 0.25 and OR = 0.39, respectively).
Conclusion
The present study revealed that the selection of the antihypertensive drug class in elderly patients is influenced not only by comorbid conditions present but also by socio‐demographic and clinical characteristics, such as age, sex, living alone, polymorbidity and immobilization. These characteristics reflect the doctor's perception of risk from pharmacotherapy of hypertension in elderly patients. Copyright © 2009 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/pds.1839 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734157324</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>734157324</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3919-58ac588cc98b1f6333681b0a8b30a2cdd4168298ddd949fd7e5d39751aa831f33</originalsourceid><addsrcrecordid>eNp9kctOxCAUhonReBlNfALTnW6qUEqBpfEyYzRq4m1JGDjNoJ22Qkedt5dmGl3pigN8_784H0L7BB8TjLOT1oZjIqhcQ9sES5kSxvh6PzOaClbILbQTwivG8U_mm2iLSE4Ex3wbfT3OIIGyBNMlTZkEqOIENml156DuDkNiZtrr-OZd6JwJSVMnXcyYWeMM9Bldd262bMF3UAf3AckcrDMxH0m3gqGy4Ktlf32omg_95vQu2ih1FWBvOEfo6fLi8WyS3tyNr85Ob1JDJZEpE9owIYyRYkrKglJaCDLFWkwp1pmxNieFyKSw1spclpYDs1RyRrQWlJSUjtDhqrf1zfsCQqfmLhioKl1DswiK05wwTrM8kkf_kiTjWSFznMlf1PgmBA-lar2ba79UBKveiIpGVG8kogdD62IaF_MLDgoikK6AT1fB8s8idX_-MBQOfPQBXz-89m-q4JQz9XI7VtcThseXhVDP9BsFGaTJ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1272694029</pqid></control><display><type>article</type><title>The effect of selected patient's characteristics on the choice of antihypertensive medication in the elderly in Slovakia</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Wawruch, Martin ; Dukat, Andrej ; Murin, Jan ; Wsolova, Ladislava ; Kuzelova, Magdalena ; Macugova, Agata ; Wimmer Jr, Gejza ; Shah, Rashmi</creator><creatorcontrib>Wawruch, Martin ; Dukat, Andrej ; Murin, Jan ; Wsolova, Ladislava ; Kuzelova, Magdalena ; Macugova, Agata ; Wimmer Jr, Gejza ; Shah, Rashmi</creatorcontrib><description>Purpose
The aim of the present study was to determine which patient‐related characteristics influence the selection of the antihypertensive drug class in elderly patients in Slovakia.
Methods
The sample for our study (n = 401) was selected from 1045 patients admitted to the Department of Internal Medicine of a general hospital during the period of 1 December 2003—31 March 2005. Patients aged 65 or more with documented arterial hypertension and treated with at least one antihypertensive drug were enrolled in our retrospective study. Specific socio‐demographic and clinical characteristics as well as cardiovascular comorbid conditions were evaluated as potential factors that could have influenced the choice of antihypertensive drug class.
Results
The most frequently prescribed antihypertensive drugs were angiotensin‐converting enzyme (ACE) inhibitors and diuretics (61.8% and 60.1% of patients, respectively). Patients aged ≥ 85 years had lower probability of ACE inhibitors prescription (OR = 0.49). Females had higher chance of calcium channel blockers use (OR = 3.84) and lower odds of diuretics administration (OR = 0.50). In patients living alone, ACE inhibitors were preferred (OR = 2.16). The use of diuretics was more frequent in polymorbid patients (OR = 1.95). Immobile patients had lower chance of being prescribed beta‐blockers and calcium channel blockers (OR = 0.25 and OR = 0.39, respectively).
Conclusion
The present study revealed that the selection of the antihypertensive drug class in elderly patients is influenced not only by comorbid conditions present but also by socio‐demographic and clinical characteristics, such as age, sex, living alone, polymorbidity and immobilization. These characteristics reflect the doctor's perception of risk from pharmacotherapy of hypertension in elderly patients. Copyright © 2009 John Wiley & Sons, Ltd.</description><identifier>ISSN: 1053-8569</identifier><identifier>EISSN: 1099-1557</identifier><identifier>DOI: 10.1002/pds.1839</identifier><identifier>PMID: 19718707</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Angiotensin-Converting Enzyme Inhibitors - therapeutic use ; Antihypertensive Agents - therapeutic use ; antihypertensive drug class ; Cardiovascular Diseases - drug therapy ; Cardiovascular Diseases - epidemiology ; Comorbidity ; Drug Therapy, Combination ; Drug Utilization ; Female ; Humans ; Hypertension - drug therapy ; Hypertension - epidemiology ; Immobilization ; living alone ; Male ; polymorbidity ; Practice Patterns, Physicians ; Retrospective Studies ; Sex Factors ; Slovakia - epidemiology ; socio-demographic characteristics ; Socioeconomic Factors</subject><ispartof>Pharmacoepidemiology and drug safety, 2009-12, Vol.18 (12), p.1199-1205</ispartof><rights>Copyright © 2009 John Wiley & Sons, Ltd.</rights><rights>Copyright (c) 2009 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3919-58ac588cc98b1f6333681b0a8b30a2cdd4168298ddd949fd7e5d39751aa831f33</citedby><cites>FETCH-LOGICAL-c3919-58ac588cc98b1f6333681b0a8b30a2cdd4168298ddd949fd7e5d39751aa831f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpds.1839$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpds.1839$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19718707$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wawruch, Martin</creatorcontrib><creatorcontrib>Dukat, Andrej</creatorcontrib><creatorcontrib>Murin, Jan</creatorcontrib><creatorcontrib>Wsolova, Ladislava</creatorcontrib><creatorcontrib>Kuzelova, Magdalena</creatorcontrib><creatorcontrib>Macugova, Agata</creatorcontrib><creatorcontrib>Wimmer Jr, Gejza</creatorcontrib><creatorcontrib>Shah, Rashmi</creatorcontrib><title>The effect of selected patient's characteristics on the choice of antihypertensive medication in the elderly in Slovakia</title><title>Pharmacoepidemiology and drug safety</title><addtitle>Pharmacoepidem. Drug Safe</addtitle><description>Purpose
The aim of the present study was to determine which patient‐related characteristics influence the selection of the antihypertensive drug class in elderly patients in Slovakia.
Methods
The sample for our study (n = 401) was selected from 1045 patients admitted to the Department of Internal Medicine of a general hospital during the period of 1 December 2003—31 March 2005. Patients aged 65 or more with documented arterial hypertension and treated with at least one antihypertensive drug were enrolled in our retrospective study. Specific socio‐demographic and clinical characteristics as well as cardiovascular comorbid conditions were evaluated as potential factors that could have influenced the choice of antihypertensive drug class.
Results
The most frequently prescribed antihypertensive drugs were angiotensin‐converting enzyme (ACE) inhibitors and diuretics (61.8% and 60.1% of patients, respectively). Patients aged ≥ 85 years had lower probability of ACE inhibitors prescription (OR = 0.49). Females had higher chance of calcium channel blockers use (OR = 3.84) and lower odds of diuretics administration (OR = 0.50). In patients living alone, ACE inhibitors were preferred (OR = 2.16). The use of diuretics was more frequent in polymorbid patients (OR = 1.95). Immobile patients had lower chance of being prescribed beta‐blockers and calcium channel blockers (OR = 0.25 and OR = 0.39, respectively).
Conclusion
The present study revealed that the selection of the antihypertensive drug class in elderly patients is influenced not only by comorbid conditions present but also by socio‐demographic and clinical characteristics, such as age, sex, living alone, polymorbidity and immobilization. These characteristics reflect the doctor's perception of risk from pharmacotherapy of hypertension in elderly patients. Copyright © 2009 John Wiley & Sons, Ltd.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>antihypertensive drug class</subject><subject>Cardiovascular Diseases - drug therapy</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Comorbidity</subject><subject>Drug Therapy, Combination</subject><subject>Drug Utilization</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - epidemiology</subject><subject>Immobilization</subject><subject>living alone</subject><subject>Male</subject><subject>polymorbidity</subject><subject>Practice Patterns, Physicians</subject><subject>Retrospective Studies</subject><subject>Sex Factors</subject><subject>Slovakia - epidemiology</subject><subject>socio-demographic characteristics</subject><subject>Socioeconomic Factors</subject><issn>1053-8569</issn><issn>1099-1557</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctOxCAUhonReBlNfALTnW6qUEqBpfEyYzRq4m1JGDjNoJ22Qkedt5dmGl3pigN8_784H0L7BB8TjLOT1oZjIqhcQ9sES5kSxvh6PzOaClbILbQTwivG8U_mm2iLSE4Ex3wbfT3OIIGyBNMlTZkEqOIENml156DuDkNiZtrr-OZd6JwJSVMnXcyYWeMM9Bldd262bMF3UAf3AckcrDMxH0m3gqGy4Ktlf32omg_95vQu2ih1FWBvOEfo6fLi8WyS3tyNr85Ob1JDJZEpE9owIYyRYkrKglJaCDLFWkwp1pmxNieFyKSw1spclpYDs1RyRrQWlJSUjtDhqrf1zfsCQqfmLhioKl1DswiK05wwTrM8kkf_kiTjWSFznMlf1PgmBA-lar2ba79UBKveiIpGVG8kogdD62IaF_MLDgoikK6AT1fB8s8idX_-MBQOfPQBXz-89m-q4JQz9XI7VtcThseXhVDP9BsFGaTJ</recordid><startdate>200912</startdate><enddate>200912</enddate><creator>Wawruch, Martin</creator><creator>Dukat, Andrej</creator><creator>Murin, Jan</creator><creator>Wsolova, Ladislava</creator><creator>Kuzelova, Magdalena</creator><creator>Macugova, Agata</creator><creator>Wimmer Jr, Gejza</creator><creator>Shah, Rashmi</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200912</creationdate><title>The effect of selected patient's characteristics on the choice of antihypertensive medication in the elderly in Slovakia</title><author>Wawruch, Martin ; Dukat, Andrej ; Murin, Jan ; Wsolova, Ladislava ; Kuzelova, Magdalena ; Macugova, Agata ; Wimmer Jr, Gejza ; Shah, Rashmi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3919-58ac588cc98b1f6333681b0a8b30a2cdd4168298ddd949fd7e5d39751aa831f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>antihypertensive drug class</topic><topic>Cardiovascular Diseases - drug therapy</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Comorbidity</topic><topic>Drug Therapy, Combination</topic><topic>Drug Utilization</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - epidemiology</topic><topic>Immobilization</topic><topic>living alone</topic><topic>Male</topic><topic>polymorbidity</topic><topic>Practice Patterns, Physicians</topic><topic>Retrospective Studies</topic><topic>Sex Factors</topic><topic>Slovakia - epidemiology</topic><topic>socio-demographic characteristics</topic><topic>Socioeconomic Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wawruch, Martin</creatorcontrib><creatorcontrib>Dukat, Andrej</creatorcontrib><creatorcontrib>Murin, Jan</creatorcontrib><creatorcontrib>Wsolova, Ladislava</creatorcontrib><creatorcontrib>Kuzelova, Magdalena</creatorcontrib><creatorcontrib>Macugova, Agata</creatorcontrib><creatorcontrib>Wimmer Jr, Gejza</creatorcontrib><creatorcontrib>Shah, Rashmi</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacoepidemiology and drug safety</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wawruch, Martin</au><au>Dukat, Andrej</au><au>Murin, Jan</au><au>Wsolova, Ladislava</au><au>Kuzelova, Magdalena</au><au>Macugova, Agata</au><au>Wimmer Jr, Gejza</au><au>Shah, Rashmi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of selected patient's characteristics on the choice of antihypertensive medication in the elderly in Slovakia</atitle><jtitle>Pharmacoepidemiology and drug safety</jtitle><addtitle>Pharmacoepidem. Drug Safe</addtitle><date>2009-12</date><risdate>2009</risdate><volume>18</volume><issue>12</issue><spage>1199</spage><epage>1205</epage><pages>1199-1205</pages><issn>1053-8569</issn><eissn>1099-1557</eissn><abstract>Purpose
The aim of the present study was to determine which patient‐related characteristics influence the selection of the antihypertensive drug class in elderly patients in Slovakia.
Methods
The sample for our study (n = 401) was selected from 1045 patients admitted to the Department of Internal Medicine of a general hospital during the period of 1 December 2003—31 March 2005. Patients aged 65 or more with documented arterial hypertension and treated with at least one antihypertensive drug were enrolled in our retrospective study. Specific socio‐demographic and clinical characteristics as well as cardiovascular comorbid conditions were evaluated as potential factors that could have influenced the choice of antihypertensive drug class.
Results
The most frequently prescribed antihypertensive drugs were angiotensin‐converting enzyme (ACE) inhibitors and diuretics (61.8% and 60.1% of patients, respectively). Patients aged ≥ 85 years had lower probability of ACE inhibitors prescription (OR = 0.49). Females had higher chance of calcium channel blockers use (OR = 3.84) and lower odds of diuretics administration (OR = 0.50). In patients living alone, ACE inhibitors were preferred (OR = 2.16). The use of diuretics was more frequent in polymorbid patients (OR = 1.95). Immobile patients had lower chance of being prescribed beta‐blockers and calcium channel blockers (OR = 0.25 and OR = 0.39, respectively).
Conclusion
The present study revealed that the selection of the antihypertensive drug class in elderly patients is influenced not only by comorbid conditions present but also by socio‐demographic and clinical characteristics, such as age, sex, living alone, polymorbidity and immobilization. These characteristics reflect the doctor's perception of risk from pharmacotherapy of hypertension in elderly patients. Copyright © 2009 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>19718707</pmid><doi>10.1002/pds.1839</doi><tpages>7</tpages></addata></record> |
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| subjects | Age Factors Aged Aged, 80 and over Angiotensin-Converting Enzyme Inhibitors - therapeutic use Antihypertensive Agents - therapeutic use antihypertensive drug class Cardiovascular Diseases - drug therapy Cardiovascular Diseases - epidemiology Comorbidity Drug Therapy, Combination Drug Utilization Female Humans Hypertension - drug therapy Hypertension - epidemiology Immobilization living alone Male polymorbidity Practice Patterns, Physicians Retrospective Studies Sex Factors Slovakia - epidemiology socio-demographic characteristics Socioeconomic Factors |
| title | The effect of selected patient's characteristics on the choice of antihypertensive medication in the elderly in Slovakia |
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