Pharmacological Characterization of 3-[3-tert-Butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic Acid (AM103), a Novel Selective 5-Lipoxygenase-Activating Protein Inhibitor That Reduces Acute and Chronic Inflammation

Leukotrienes (LTs) are proinflammatory lipid mediators synthesized by the conversion of arachidonic acid (AA) to LTA 4 by the enzyme 5-lipoxygenase (5-LO) in the presence of 5-LO-activating protein (FLAP). 3-[3- tert -Butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1 H -i...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2009-12, Vol.331 (3), p.1042-1050
Hauptverfasser:	Lorrain, Daniel S, Bain, Gretchen, Correa, Lucia D, Chapman, Charles, Broadhead, Alex R, Santini, Angelina M, Prodanovich, Pat, Darlington, Janice V, Hutchinson, John H, King, Christopher, Lee, Catherine, Baccei, Christopher, Li, Yiwei, Arruda, Jeannie M, Evans, Jilly F
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Lipoxygenase-Activating Proteins Acute Disease Administration, Oral Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Asthma - drug therapy Asthma - enzymology Asthma - metabolism Carrier Proteins - antagonists & inhibitors Chronic Disease Disease Models, Animal Dose-Response Relationship, Drug Extravasation of Diagnostic and Therapeutic Materials - drug therapy Extravasation of Diagnostic and Therapeutic Materials - enzymology Extravasation of Diagnostic and Therapeutic Materials - metabolism Female Humans Indoles - pharmacology Indoles - therapeutic use Inflammation - drug therapy Inflammation - enzymology Inflammation - metabolism Leukotriene B4 - biosynthesis Leukotriene B4 - blood Male Membrane Proteins - antagonists & inhibitors Mice Mice, Inbred BALB C Pneumonia - drug therapy Pneumonia - enzymology Pneumonia - metabolism Propionates - pharmacology Propionates - therapeutic use Rats Rats, Sprague-Dawley Zymosan
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