β-Lactotensin derived from bovine β-lactoglobulin suppresses food intake via the CRF system followed by the CGRP system in mice

We found that β-lactotensin (His-Ile-Arg-Leu), which has been isolated as an ileum-contracting peptide from chymotrypsin digest of bovine β-lactoglobulin, dose-dependently suppresses food intake after intracerebroventricular (i.c.v.) or intraperitoneal administration at a dose of 40 nmol/mouse or 10...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2009-12, Vol.30 (12), p.2228-2232
Hauptverfasser:	Hou, I-Ching, Yoshikawa, Masaaki, Ohinata, Kousaku
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcitonin gene-related peptide Corticotropin releasing factor Corticotropin-Releasing Hormone - antagonists & inhibitors Corticotropin-Releasing Hormone - metabolism Corticotropin-Releasing Hormone - pharmacology Eating - drug effects Food intake Fundamental and applied biological sciences. Psychology Lactoglobulins - metabolism Male Mice Neurotensin Oligopeptides - metabolism Oligopeptides - pharmacology Peptide Fragments - pharmacology Piperidines - pharmacology Receptors, Neurotensin - antagonists & inhibitors Receptors, Neurotensin - metabolism Vertebrates: endocrinology β-Lactotensin
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