Self-modulation of neocortical pyramidal neurons by endocannabinoids

This study finds that excitatory neurons in cortical layer 2/3 can respond to their own firing with persistent hyperpolarization, termed slow self-inhibition or SSI. This process is mediated by endocannabinoids and regulates neuronal excitability. Control of pyramidal neuron excitability is vital fo...

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Veröffentlicht in:	Nature neuroscience 2009-12, Vol.12 (12), p.1488-1490
Hauptverfasser:	Marinelli, Silvia, Pacioni, Simone, Cannich, Astrid, Marsicano, Giovanni, Bacci, Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animals Behavioral Sciences Benzoxazines - pharmacology Biological Techniques Biomedical and Life Sciences Biomedicine brief-communication Cannabinoid Receptor Modulators - metabolism Cannabinoids Cannabinoids - pharmacology Dendrites - physiology Endocannabinoids gamma-Aminobutyric Acid - physiology Glutamic Acid - physiology Mice Morpholines - pharmacology Naphthalenes - pharmacology Neocortex Neocortex - cytology Neural Inhibition - physiology Neurobiology Neurons Neurosciences Organ Culture Techniques Patch-Clamp Techniques Physiological aspects Properties Pyramidal Cells - drug effects Pyramidal Cells - metabolism Pyramidal Cells - ultrastructure Rats Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB1 - physiology
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