Self-modulation of neocortical pyramidal neurons by endocannabinoids
Control of pyramidal neuron excitability is vital for the functioning of the neocortex. Somatodendritic slow self-inhibition (SSI) allows inhibitory neurons to regulate their own activity, but the existence of similar mechanisms in excitatory cells has not been shown. We found that in rodents endoca...
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| Veröffentlicht in: | Nature neuroscience 2009-12, Vol.12 (12), p.1488-1490 |
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| container_title | Nature neuroscience |
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| creator | Pacioni, Simone Bacci, Alberto Cannich, Astrid Marinelli, Silvia Marsicano, Giovanni |
| description | Control of pyramidal neuron excitability is vital for the functioning of the neocortex. Somatodendritic slow self-inhibition (SSI) allows inhibitory neurons to regulate their own activity, but the existence of similar mechanisms in excitatory cells has not been shown. We found that in rodents endocannabinoids mediated SSI and long-term modulation of inhibitory connections in layer 2/3 pyramidal neurons with a distinct dendritic morphology, suggesting that a glutamatergic network in cortical circuits is self-regulated. |
| doi_str_mv | 10.1038/nn.2430 |
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Somatodendritic slow self-inhibition (SSI) allows inhibitory neurons to regulate their own activity, but the existence of similar mechanisms in excitatory cells has not been shown. 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Somatodendritic slow self-inhibition (SSI) allows inhibitory neurons to regulate their own activity, but the existence of similar mechanisms in excitatory cells has not been shown. 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Somatodendritic slow self-inhibition (SSI) allows inhibitory neurons to regulate their own activity, but the existence of similar mechanisms in excitatory cells has not been shown. We found that in rodents endocannabinoids mediated SSI and long-term modulation of inhibitory connections in layer 2/3 pyramidal neurons with a distinct dendritic morphology, suggesting that a glutamatergic network in cortical circuits is self-regulated.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>19915567</pmid><doi>10.1038/nn.2430</doi><tpages>3</tpages></addata></record> |
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| subjects | Animal Genetics and Genomics Animals Behavioral Sciences Benzoxazines - pharmacology Biological Techniques Biomedical and Life Sciences Biomedicine brief-communication Cannabinoid Receptor Modulators - metabolism Cannabinoids Cannabinoids - pharmacology Dendrites - physiology Endocannabinoids gamma-Aminobutyric Acid - physiology Glutamic Acid - physiology Mice Morpholines - pharmacology Naphthalenes - pharmacology Neocortex Neocortex - cytology Neural Inhibition - physiology Neurobiology Neurons Neurosciences Organ Culture Techniques Patch-Clamp Techniques Physiological aspects Properties Pyramidal Cells - drug effects Pyramidal Cells - metabolism Pyramidal Cells - ultrastructure Rats Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB1 - physiology |
| title | Self-modulation of neocortical pyramidal neurons by endocannabinoids |
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