Engineering Craniofacial Structures: Facing the Challenge
The human innate regenerative ability is known to be limited by the intensity of the insult together with the availability of progenitor cells, which may cause certain irreparable damage. It is only recently that the paradigm of tissue engineering found its way to the treatment of irreversibly affec...
Gespeichert in:
| Veröffentlicht in: | Journal of Dental Research 2009-12, Vol.88 (12), p.1077-1091 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1091 |
|---|---|
| container_issue | 12 |
| container_start_page | 1077 |
| container_title | Journal of Dental Research |
| container_volume | 88 |
| creator | Zaky, S.H. Cancedda, R. |
| description | The human innate regenerative ability is known to be limited by the intensity of the insult together with the availability of progenitor cells, which may cause certain irreparable damage. It is only recently that the paradigm of tissue engineering found its way to the treatment of irreversibly affected body structures with the challenge of reconstructing the lost part. In the current review, we underline recent trials that target engineering of human craniofacial structures, mainly bone, cartilage, and teeth. We analyze the applied engineering strategies relative to the selection of cell types to lay down a specific targeted tissue, together with their association with an escorting scaffold for a particular engineered site, and discuss their necessity to be sustained by growth factors. Challenges and expectations for facial skeletal engineering are discussed in the context of future treatment. |
| doi_str_mv | 10.1177/0022034509349926 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734153818</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0022034509349926</sage_id><sourcerecordid>734153818</sourcerecordid><originalsourceid>FETCH-LOGICAL-c431t-af9858055a446745a2461dd320a3698ba43cb58e25a2f57418c39213631eb2073</originalsourceid><addsrcrecordid>eNp1kE1Lw0AQhhdRbK3ePUlunqI7-5Hd9SahVaHgQT0vm3SSpqRJ3U0O_vtuaUEQPA3M88wL8xJyC_QBQKlHShmjXEhquDCGZWdkClKIlEoD52R6wOmBT8hVCBtKwTDNL8kEjDZKaTklZt7VTYfom65Ocu-6pq9c2bg2-Rj8WA6jx_CULOIq8mGNSb52bYtdjdfkonJtwJvTnJGvxfwzf02X7y9v-fMyLQWHIXWV0VJTKZ0QmRLSMZHBasUZdTwzunCCl4XUyCKppBKgS24Y8IwDFowqPiP3x9yd779HDIPdNqHEtnUd9mOwiguQXIOOJj2ape9D8FjZnW-2zv9YoPbQl_3bVzy5O4WPxRZXvwengqKQHoXgarSbfvRdfPb_wD1l4G-0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>734153818</pqid></control><display><type>article</type><title>Engineering Craniofacial Structures: Facing the Challenge</title><source>Access via SAGE</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Zaky, S.H. ; Cancedda, R.</creator><creatorcontrib>Zaky, S.H. ; Cancedda, R.</creatorcontrib><description>The human innate regenerative ability is known to be limited by the intensity of the insult together with the availability of progenitor cells, which may cause certain irreparable damage. It is only recently that the paradigm of tissue engineering found its way to the treatment of irreversibly affected body structures with the challenge of reconstructing the lost part. In the current review, we underline recent trials that target engineering of human craniofacial structures, mainly bone, cartilage, and teeth. We analyze the applied engineering strategies relative to the selection of cell types to lay down a specific targeted tissue, together with their association with an escorting scaffold for a particular engineered site, and discuss their necessity to be sustained by growth factors. Challenges and expectations for facial skeletal engineering are discussed in the context of future treatment.</description><identifier>ISSN: 0022-0345</identifier><identifier>EISSN: 1544-0591</identifier><identifier>DOI: 10.1177/0022034509349926</identifier><identifier>PMID: 19897785</identifier><language>eng</language><publisher>United States: SAGE Publications</publisher><subject>Animals ; Cartilage - anatomy & histology ; Dentistry ; Facial Bones - anatomy & histology ; Humans ; Intercellular Signaling Peptides and Proteins - therapeutic use ; Neovascularization, Physiologic - physiology ; Regeneration - physiology ; Skull - anatomy & histology ; Stem Cells - physiology ; Tissue Engineering ; Tissue Scaffolds - classification ; Tooth - anatomy & histology</subject><ispartof>Journal of Dental Research, 2009-12, Vol.88 (12), p.1077-1091</ispartof><rights>2009 International & American Associations for Dental Research</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-af9858055a446745a2461dd320a3698ba43cb58e25a2f57418c39213631eb2073</citedby><cites>FETCH-LOGICAL-c431t-af9858055a446745a2461dd320a3698ba43cb58e25a2f57418c39213631eb2073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0022034509349926$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0022034509349926$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>313,314,780,784,792,21819,27922,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19897785$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zaky, S.H.</creatorcontrib><creatorcontrib>Cancedda, R.</creatorcontrib><title>Engineering Craniofacial Structures: Facing the Challenge</title><title>Journal of Dental Research</title><addtitle>J Dent Res</addtitle><description>The human innate regenerative ability is known to be limited by the intensity of the insult together with the availability of progenitor cells, which may cause certain irreparable damage. It is only recently that the paradigm of tissue engineering found its way to the treatment of irreversibly affected body structures with the challenge of reconstructing the lost part. In the current review, we underline recent trials that target engineering of human craniofacial structures, mainly bone, cartilage, and teeth. We analyze the applied engineering strategies relative to the selection of cell types to lay down a specific targeted tissue, together with their association with an escorting scaffold for a particular engineered site, and discuss their necessity to be sustained by growth factors. Challenges and expectations for facial skeletal engineering are discussed in the context of future treatment.</description><subject>Animals</subject><subject>Cartilage - anatomy & histology</subject><subject>Dentistry</subject><subject>Facial Bones - anatomy & histology</subject><subject>Humans</subject><subject>Intercellular Signaling Peptides and Proteins - therapeutic use</subject><subject>Neovascularization, Physiologic - physiology</subject><subject>Regeneration - physiology</subject><subject>Skull - anatomy & histology</subject><subject>Stem Cells - physiology</subject><subject>Tissue Engineering</subject><subject>Tissue Scaffolds - classification</subject><subject>Tooth - anatomy & histology</subject><issn>0022-0345</issn><issn>1544-0591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1Lw0AQhhdRbK3ePUlunqI7-5Hd9SahVaHgQT0vm3SSpqRJ3U0O_vtuaUEQPA3M88wL8xJyC_QBQKlHShmjXEhquDCGZWdkClKIlEoD52R6wOmBT8hVCBtKwTDNL8kEjDZKaTklZt7VTYfom65Ocu-6pq9c2bg2-Rj8WA6jx_CULOIq8mGNSb52bYtdjdfkonJtwJvTnJGvxfwzf02X7y9v-fMyLQWHIXWV0VJTKZ0QmRLSMZHBasUZdTwzunCCl4XUyCKppBKgS24Y8IwDFowqPiP3x9yd779HDIPdNqHEtnUd9mOwiguQXIOOJj2ape9D8FjZnW-2zv9YoPbQl_3bVzy5O4WPxRZXvwengqKQHoXgarSbfvRdfPb_wD1l4G-0</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Zaky, S.H.</creator><creator>Cancedda, R.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091201</creationdate><title>Engineering Craniofacial Structures: Facing the Challenge</title><author>Zaky, S.H. ; Cancedda, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-af9858055a446745a2461dd320a3698ba43cb58e25a2f57418c39213631eb2073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Cartilage - anatomy & histology</topic><topic>Dentistry</topic><topic>Facial Bones - anatomy & histology</topic><topic>Humans</topic><topic>Intercellular Signaling Peptides and Proteins - therapeutic use</topic><topic>Neovascularization, Physiologic - physiology</topic><topic>Regeneration - physiology</topic><topic>Skull - anatomy & histology</topic><topic>Stem Cells - physiology</topic><topic>Tissue Engineering</topic><topic>Tissue Scaffolds - classification</topic><topic>Tooth - anatomy & histology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zaky, S.H.</creatorcontrib><creatorcontrib>Cancedda, R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Dental Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zaky, S.H.</au><au>Cancedda, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Engineering Craniofacial Structures: Facing the Challenge</atitle><jtitle>Journal of Dental Research</jtitle><addtitle>J Dent Res</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>88</volume><issue>12</issue><spage>1077</spage><epage>1091</epage><pages>1077-1091</pages><issn>0022-0345</issn><eissn>1544-0591</eissn><abstract>The human innate regenerative ability is known to be limited by the intensity of the insult together with the availability of progenitor cells, which may cause certain irreparable damage. It is only recently that the paradigm of tissue engineering found its way to the treatment of irreversibly affected body structures with the challenge of reconstructing the lost part. In the current review, we underline recent trials that target engineering of human craniofacial structures, mainly bone, cartilage, and teeth. We analyze the applied engineering strategies relative to the selection of cell types to lay down a specific targeted tissue, together with their association with an escorting scaffold for a particular engineered site, and discuss their necessity to be sustained by growth factors. Challenges and expectations for facial skeletal engineering are discussed in the context of future treatment.</abstract><cop>United States</cop><pub>SAGE Publications</pub><pmid>19897785</pmid><doi>10.1177/0022034509349926</doi><tpages>15</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-0345 |
| ispartof | Journal of Dental Research, 2009-12, Vol.88 (12), p.1077-1091 |
| issn | 0022-0345 1544-0591 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_734153818 |
| source | Access via SAGE; MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Cartilage - anatomy & histology Dentistry Facial Bones - anatomy & histology Humans Intercellular Signaling Peptides and Proteins - therapeutic use Neovascularization, Physiologic - physiology Regeneration - physiology Skull - anatomy & histology Stem Cells - physiology Tissue Engineering Tissue Scaffolds - classification Tooth - anatomy & histology |
| title | Engineering Craniofacial Structures: Facing the Challenge |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T17%3A51%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Engineering%20Craniofacial%20Structures:%20Facing%20the%20Challenge&rft.jtitle=Journal%20of%20Dental%20Research&rft.au=Zaky,%20S.H.&rft.date=2009-12-01&rft.volume=88&rft.issue=12&rft.spage=1077&rft.epage=1091&rft.pages=1077-1091&rft.issn=0022-0345&rft.eissn=1544-0591&rft_id=info:doi/10.1177/0022034509349926&rft_dat=%3Cproquest_cross%3E734153818%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=734153818&rft_id=info:pmid/19897785&rft_sage_id=10.1177_0022034509349926&rfr_iscdi=true |