Ischemic preconditioning preserves connexin 43 phosphorylation during sustained ischemia in pig hearts in vivo

ABSTRACT During myocardial ischemia, connexin 43 (Cx43) is dephosphorylated in vitro, and the subsequent opening of gap junctions formed by two opposing Cx43 hexamers was suggested to propagate ischemia/reperfusion injury. Reduction of infarct size (IS) by ischemic preconditioning (IP) involves acti...

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Veröffentlicht in:	The FASEB journal 2003-07, Vol.17 (10), p.1355-1357
Hauptverfasser:	Schulz, Rainer, Gres, Petra, Skyschally, Andreas, Duschin, Alexej, Belosjorow, Sergej, Konietzka, Ina, Heusch, Gerd
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Connexin 43 - analysis Connexin 43 - metabolism Enzyme Inhibitors - pharmacology Imidazoles - pharmacology Ischemic Preconditioning, Myocardial Kinetics Mitogen-Activated Protein Kinase 11 Mitogen-Activated Protein Kinase 14 Mitogen-Activated Protein Kinases - analysis Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Models, Biological Myocardial Infarction - pathology Myocardial Ischemia - enzymology Myocardial Ischemia - metabolism Myocardium - chemistry Myocardium - enzymology Phosphorylation preconditioning Protein Kinase C - analysis Protein Kinase C-alpha Protein Kinase C-epsilon protein kinases Pyridines - pharmacology reperfusion Swine
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