A Stereoselective Approach to Nucleosides and 4′-Thioanalogues from Acyclic Precursors
d- and l-nucleosides and analogues thereof, including the 4′-thionucleoside series, are one of the most important biological and pharmaceutically active classes of compounds. A novel approach to their synthesis from chiral acyclic thioaminal, bearing the nucleobase, is described.
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| Veröffentlicht in: | Journal of the American Chemical Society 2009-12, Vol.131 (47), p.17242-17245 |
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| container_end_page | 17245 |
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| container_issue | 47 |
| container_start_page | 17242 |
| container_title | Journal of the American Chemical Society |
| container_volume | 131 |
| creator | Chapdelaine, Daniel Cardinal-David, Benoit Prévost, Michel Gagnon, Marc Thumin, Isabelle Guindon, Yvan |
| description | d- and l-nucleosides and analogues thereof, including the 4′-thionucleoside series, are one of the most important biological and pharmaceutically active classes of compounds. A novel approach to their synthesis from chiral acyclic thioaminal, bearing the nucleobase, is described. |
| doi_str_mv | 10.1021/ja905452f |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0002-7863 |
| ispartof | Journal of the American Chemical Society, 2009-12, Vol.131 (47), p.17242-17245 |
| issn | 0002-7863 1520-5126 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_734153039 |
| source | MEDLINE; ACS Publications |
| subjects | Nucleosides - chemistry Stereoisomerism Sulfhydryl Compounds - chemistry |
| title | A Stereoselective Approach to Nucleosides and 4′-Thioanalogues from Acyclic Precursors |
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