Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I

Islets of patients with type 2 diabetes mellitus (T2DM) display features of an inflammatory process including elevated levels of the cytokine IL-1β, various chemokines, and macrophages. IL-1β is a master regulator of inflammation, and IL-1 receptor type I (IL-1RI) blockage improves glycemia and insu...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2009-12, Vol.150 (12), p.5218-5229
Hauptverfasser:	Böni-Schnetzler, Marianne, Boller, Simone, Debray, Sarah, Bouzakri, Karim, Meier, Daniel T, Prazak, Richard, Kerr-Conte, Julie, Pattou, Francois, Ehses, Jan A, Schuit, Frans C, Donath, Marc Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Beta cells Blood glucose Blotting, Western Cell activation Cell Line, Tumor Cells, Cultured Chemokines Diabetes mellitus Diabetes mellitus (non-insulin dependent) Dyslipidemia Fatty acids Fatty Acids, Nonesterified - pharmacology Female Humans IL-1β Inflammation Inflammation Mediators - metabolism Insulin secretion Interleukin 1 Interleukin 1 receptor antagonist Interleukin 1 Receptor Antagonist Protein - genetics Interleukin 1 Receptor Antagonist Protein - metabolism Interleukin 1 receptors Interleukin-1beta - genetics Interleukin-1beta - metabolism Interleukin-8 - genetics Interleukin-8 - metabolism Islets of Langerhans - drug effects Islets of Langerhans - metabolism Macrophages Male Mice Mice, Inbred C57BL Mice, Knockout Middle Aged MyD88 protein Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - metabolism Receptors, Interleukin-1 - genetics Receptors, Interleukin-1 - metabolism Reverse Transcriptase Polymerase Chain Reaction TLR2 protein Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - metabolism Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-like receptors Young Adult
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